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Compound preparation of omeprazol

A technology of omeprazole and omeprazole magnesium, which is applied in the directions of drug combination, inactive components of polymer compounds, and pill delivery, etc., can solve the problem of poor absorption, maximum blood drug concentration, large difference in AUC in time to peak, etc. problem, to achieve the effect of increasing stability and slowing down degradation

Inactive Publication Date: 2007-07-25
GUANGDONG HUANAN PHARMACEUTICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Typical omeprazole enteric-coated preparations are poorly absorbed after a single dose of administration, and the maximum plasma concentration, peak time, and AUC vary greatly among individuals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment one, levoomeprazole tablet

[0029] prescription:

[0030] Levoomeprazole 20g

[0031] Calcium Lactate 100g

[0032] Sodium bicarbonate 400g

[0033] Carboxymethyl Starch Sodium 20g

[0034] Magnesium Stearate 5g

[0035] The preparation process is as follows: successively mix the prescribed amount of carboxymethyl starch sodium, calcium lactate, sodium bicarbonate, magnesium stearate, and levoomeprazole evenly, and finally directly compress the mixture into tablets to make 1000 tablets, each containing 20 mg levomeprazole.

Embodiment 2

[0036] Embodiment two, omeprazole capsule

[0037] prescription:

[0038] Omeprazole 10g

[0039] Sodium bicarbonate 550g

[0040] Carboxymethyl Starch Sodium 20g

[0041] Magnesium Stearate 5g

[0042] The preparation process is as follows: the prescription amount of sodium bicarbonate, sodium starch glycolate, magnesium stearate, and omeprazole are mixed evenly, and then the mixture is filled into capsules to make 1000 capsules, each containing 10 mg of omeprazole.

Embodiment 3

[0043] Embodiment three, levoomeprazole magnesium powder

[0044] prescription:

[0045] Levoomeprazole Magnesium 20g

[0046] Sodium bicarbonate 800g

[0047] Xylitol 100g

[0048] Lactose 100g

[0049] The preparation process is as follows: the prescription amount of sodium bicarbonate, xylitol, lactose, and omeprazole magnesium are evenly mixed, and then the mixture is divided into 1000 small bags, and each bag contains 20 mg of omeprazole magnesium.

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PUM

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Abstract

An enteric or slowly-released composition of omeprazole is prepared from omeprazole, the buffer substance for neutralizing gastric acid and improving the stability of omeprazole, and the pharmacologically acceptable assistant.

Description

technical field [0001] The invention relates to a kind of omeprazole composition preparation, in particular to a kind of omeprazole composition comprising effective treatment dose of omeprazole, buffer substance and pharmaceutically acceptable auxiliary materials. Background technique [0002] Compounds hereinafter referred to as omeprazole: Omeprazole, basic salts of omeprazole, a single enantiomer of omeprazole, basic salts of a single enantiomer of omeprazole Used to inhibit gastric acid secretion in mammals and humans by controlling gastric acid secretion at the final step of the gastric acid secretory pathway. Therefore, in general, it can be used for the prevention and treatment of gastric acid-related diseases in mammals and humans, including duodenal ulcer, gastric ulcer, gastroesophageal reflux disease, erosive esophagitis, Zollinger-Ellison syndrome, heartburn, Esophageal disease, etc. [0003] However, omeprazole is unstable in acidic and neutral environments, a...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/46A61K9/48A61K47/02A61K47/12A61K47/16A61K47/26A61K47/34A61K47/36A61K47/38A61K47/40A61P1/04
Inventor 龙超峰谢称石王金超
Owner GUANGDONG HUANAN PHARMACEUTICAL GROUP CO LTD
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