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An antitumor medicine and its preparation method

A technology of anti-tumor drugs and agents, applied in anti-tumor drugs, pharmaceutical formulations, drug combinations, etc., can solve the problems of improper drug use, many adverse reactions, strong skin vascular irritation, etc.

Active Publication Date: 2007-08-01
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the curative effect is generally not very satisfactory, the treatment period is long, the cure rate is low, and the recurrence rate is high
Most of the traditional Chinese medicine preparations currently in clinical use have complex prescriptions, and some of them contain highly toxic drugs, so there are many adverse reactions when used. effects, inappropriate medication and even death

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1. An antitumor drug, which is a medicament made of the following raw materials in the weight ratio,

[0057] Garcinia 0.5 parts by weight; Sophora flavescens 5 parts by weight.

[0058] The preparation method is to extract the active ingredients according to the conventional technology, add conventional pharmaceutical auxiliary materials, and make capsules according to the conventional technology.

Embodiment 2

[0059] Example 2. An antitumor drug, which is a medicament made of the following raw materials in the weight ratio,

[0060] Garcinia 1.5 parts by weight; Sophora flavescens 15 parts by weight.

[0061] The preparation method is to extract the active ingredients according to the conventional technology, add conventional pharmaceutical auxiliary materials, and make tablets according to the conventional technology.

Embodiment 3

[0062] Example 3. An antitumor drug, which is a medicament made of the following raw materials in the weight ratio,

[0063] Garcinia 0.8 parts by weight; Sophora flavescens 10 parts by weight.

[0064] Its preparation method steps are as follows:

[0065] (1) Garcinia cambogia coarse powder is extracted with 12 times the amount of ethyl acetate in 3 times of reflux, the combined extracts are concentrated to obtain the extract-like extract; the extract uses 6 times the volume of 5% NaHCO 3 Aqueous solution extraction, separate the alkaline water layer, adjust the pH value to about 3 with 6mol / L hydrochloric acid aqueous solution, and extract the acidic aqueous solution three times with 3 times the volume of ethyl acetate, combine the ethyl acetate layers, and wash with water until medium properties, concentrated to obtain Garcinia Cambogia Extract I; Garcinia Cambogia Extract I was dissolved with an appropriate amount of ether, added pyridine and petroleum ether respectively...

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Abstract

The invention relates to an antitumor medicament which is prepared from the following raw materials: (1) gamboges 0.5-1.5 weight parts, (2) flavescent sophora root 5-15 weight parts, or flavescent sophora root essence 0.1-0.3 weight part, sophocarpidine 0.1-0.3 weight part. The invention also discloses the process for preparing the medicament.

Description

technical field [0001] The invention relates to a pharmaceutical composition using Chinese herbal medicine as a raw material, in particular to an antitumor drug. The invention also relates to a preparation method of the antitumor drug. Background technique [0002] As a worldwide disease, tumor has become an important disease that threatens human health and survival and causes human death. According to statistics from the Ministry of Health, in my country, there are 2 million new tumor patients every year, and the number of deaths due to tumors is as high as 1.3 million per year. Efficacy and side effects are different, and often produce many serious adverse reactions, such as nausea, vomiting, bone marrow suppression and hair loss. The use of traditional Chinese medicine treatment can not only reduce the side effects of radiotherapy and chemotherapy, but also strengthen the effect of radiotherapy and chemotherapy. For patients with advanced cancer or those who cannot under...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61K36/185A61P35/00A61K31/4375
Inventor 肖伟戴翔翎凌娅王振中赵袆武
Owner JIANGSU KANION PHARMA CO LTD
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