Medicament-carrying complex calcium phosphate bone cement for spinal column reconstruction during tumour operation

A technology of calcium phosphate bone cement and drug-loaded microspheres, applied in medical science, prosthesis, etc., to achieve the effect of reducing local effects, achieving long-term stability, and gentle release concentration

Inactive Publication Date: 2007-08-08
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Drug-loaded microspheres combined with calcium phosphate bone cement for intraoperative reconstruction of spinal tumors have not been reported yet

Method used

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  • Medicament-carrying complex calcium phosphate bone cement for spinal column reconstruction during tumour operation
  • Medicament-carrying complex calcium phosphate bone cement for spinal column reconstruction during tumour operation
  • Medicament-carrying complex calcium phosphate bone cement for spinal column reconstruction during tumour operation

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Experimental program
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Effect test

Embodiment 1

[0023] 1. As 2 o 3 Preparation and performance test of albumin microspheres

[0024] (1) Method

[0025] 1. As 2 o 3 Preparation of albumin microspheres

[0026] Preparation of As by emulsification and thermal curing method 2 o 3 albumin microspheres. Will As 2 o 3 100mg and 250mg human serum albumin dissolved in 1ml, 0.15mol·L -1 NaCl solution, mix well. 25°C, add it 150r.min -1 Stir in 30ml of cottonseed oil (A). After adding, continue to stir for 5 minutes to obtain colostrum. Take another 50ml of cottonseed oil (B) at a constant speed of 130r.min -1 Stir and heat to 105°C. Add the colostrum to the cottonseed oil (B) stirred at a constant speed, and solidify for 20 minutes. Cool to room temperature with stirring in a cold water bath. The microspheres were separated by suction filtration and washed 3 times with 200 ml of anhydrous ether. Dry to light yellow As 2 o 3 Microspheres. Seal in ampoules and store in a dark place at low temperature.

[0027] 2....

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Abstract

The invention relates to drug carrier micro ball composite calcium phosphate skeleton cement used in the rebuilding construction of spine tumor surgery. The invention uses micro balls as carrier to be combined with the anti-tumor drug to obtain the carrier micro ball, then to be mixed with calcium phosphate skeleton cement, therefore, the invention can avoid blasting effect after transplantation to support releasing the anti-tumor drug and holding stable density, and support growing fresh skeleton. The invention can be used to replace CPC carrier.

Description

Technical field: [0001] The invention relates to the field of orthopedic tissue engineering, in particular to a drug-loaded microsphere composite calcium phosphate bone cement used for intraoperative reconstruction of spinal tumors and a preparation method thereof. Background technique: [0002] Spinal tumors are one of the diseases that seriously endanger human health, and can be divided into two categories: primary tumors and metastatic tumors. Among them, metastatic tumors are the main ones, accounting for more than 70%. According to statistics, malignant tumors metastasized to the spine rank third after lung and liver. Studies have shown that more than 40% of patients who died of malignant tumors have spinal metastases (references: editor-in-chief Xiao Jianru, Spine Tumor Surgery, Shanghai Science and Technology Press, 2005, first edition). With the advancement of surgical treatment concepts and techniques, surgical resection has increasingly become the primary means o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/40
Inventor 陈华江肖建如杨兴海
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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