Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Collagen modified poly(3-hydroxybutyrate-3-hydroxyvalerate) and its preparing method and application

A technology of hydroxybutyrate and hydroxyvalerate, applied in the field of collagen modified polymer and its preparation, can solve the problem of lack of cell recognition signal, degradable polymer material does not contain biological information, unfavorable cell-specific adhesion and specific gene activation and other issues, to achieve simple process, good biological activity and biocompatibility, and improve the effect of cell adhesion rate

Active Publication Date: 2010-08-11
SOUTH CHINA UNIV OF TECH
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, degradable polymer materials do not contain biological information, lack cell recognition signals, and are not conducive to cell-specific adhesion and activation of specific genes.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Collagen modified poly(3-hydroxybutyrate-3-hydroxyvalerate) and its preparing method and application
  • Collagen modified poly(3-hydroxybutyrate-3-hydroxyvalerate) and its preparing method and application
  • Collagen modified poly(3-hydroxybutyrate-3-hydroxyvalerate) and its preparing method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Embodiment 2

Embodiment 3

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
tensile strengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a modified collagen with 5-30% collagen, 50-90% poly-3-hydrobutanoate-3-hydrovalerate and 5-20% partial amidifying polyacrylamide and making method and application, which comprises the following steps: adopting PHBV as basic material to make PHBV film; irradiating through ultraviolet; grafting polyacrylamide; making amidified PHBV to do Hofmann decomposing reaction; producing amidifying PHBV; bonding PHBV and collagen with excellent compatibility and dynamics.

Description

Technical field The present invention relates to a modified biological material and its preparation technology, in particular to a collagen-modified poly(3-hydroxybutyrate-3-hydroxyvalerate) with good biocompatibility and mechanical properties and its Preparation. Background technique Poly(3-hydroxybutyrate-3-hydroxyvalerate) (PHBV) is a natural polyester polymer synthesized by microorganisms. Due to its good biocompatibility, degradability and piezoelectricity, it has broad application prospects in the fields of drug controlled release, sutures, artificial skin, cartilage and bone tissue engineering. However, PHBV has poor hydrophilicity, and cells adhere weakly to its surface. For this reason, introducing functional groups on the surface of PHBV to improve the hydrophilicity and biological activity of the PHBV surface, thereby improving the interaction between cells and materials, has always been a hot topic in functionalization research on biomedical materials. Althou...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/91C08G81/00C08J7/18C08K5/07A61K47/34A61L27/06A61L27/24A61L24/10A61K47/42
Inventor 王迎军柯渔任力
Owner SOUTH CHINA UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com