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Nanometer elemental selenium coupled with liquid amino acid and the method for preparing and preserving the same

A technology of nano-element and amino acid, applied in the direction of drug combination, sulfur/selenium/tellurium active ingredient, heterocyclic compound active ingredient, etc., can solve problems such as unsolved single amino acid coupling, unfavorable dosage form development, and limited medical application, etc., to achieve The effect of low production cost, strong health care effect, and expanded application range

Inactive Publication Date: 2007-09-26
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product involved in this patent is nano-selenium mixed with a variety of amino acids in a solid state. Its disadvantage is that the product can only be stored in a solid state, which is not conducive to the development of dosage forms and other restrictions; secondly, it does not solve the problem of single amino acid coupling. limit its medicinal application
Moreover, the preparation method involved in this patent includes separation and drying. During this process, the dispersion state of nano-selenium may change, affecting the efficacy of the product.

Method used

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  • Nanometer elemental selenium coupled with liquid amino acid and the method for preparing and preserving the same
  • Nanometer elemental selenium coupled with liquid amino acid and the method for preparing and preserving the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] At normal temperature and pressure (15-35°C, 1 standard atmospheric pressure), the concentration is 3mol L -1 Each 15ml of the glycine solution was added to five 50ml volumetric flasks respectively, and then the concentration was 0.1mol L -1 Add 1ml of each vitamin C solution to these 5 volumetric flasks, shake gently to mix them well, and then add them dropwise with a concentration of 4×10 -4 mol L -1 0.5, 1, 2, 4, 8ml of the selenium dioxide solution, shake gently while adding dropwise, wait until the red color does not change, set the volume to 50ml with twice distilled water, and a series of selenium concentrations of 4, 8, 16 , 32, 64 μmol L -1 target product. Measured by a BI9000AT laser scattering instrument (American Brookhaven). The average particle size of the nanoparticles in the product is in the range of 30-100nm, see attached table 1. The product can be stored in the form of sol in aqueous solution at 2-10°C.

[0021] Selenium concentration ...

Embodiment 2

[0023] At normal temperature and pressure (15-35°C, 1 standard atmospheric pressure), the concentration is 3mol L -1 Each 15ml of the proline solution was added to five 50ml volumetric flasks respectively, and then the concentration was 0.1mol L -1 Add 1ml of each vitamin C solution to these 5 volumetric flasks, shake gently to mix them well, and then add them dropwise with a concentration of 4×10 -4 mol L -1 0.5, 1, 2, 4, 8ml of selenium dioxide solution, shake gently while adding dropwise, wait until the red color no longer changes, set the volume to 50ml, and a series of selenium concentrations of 4, 8, 16, 32, 64μmol·L -1 target product. Measured by a BI9000AT laser scattering instrument (American Brookhaven). The average particle size of the nanoparticles in the product is in the range of 20-100nm, see attached table 2. The product can be stored in the form of sol in aqueous solution at 2-10°C.

[0024] Selenium concentration

Embodiment 3

[0026] At normal temperature and pressure (15-35°C, 1 standard atmospheric pressure), the concentration is 3mol L -1Add 7.5ml each of the lysine solution and arginine solution to five 50ml volumetric flasks respectively, and then take the concentration to be 0.1mol L -1 Add 1ml of each vitamin C solution to these 5 volumetric flasks, shake gently to mix them well, and then add them dropwise with a concentration of 4×10 -4 mol L -1 0.5, 1, 2, 4, 8ml of sodium selenite solution, shake gently while adding dropwise, wait until the red color does not change, set the volume to 50ml, and a series of selenium concentrations of 4, 8, 16, 32 , 64 μmol L -1 target product. Measured by a BI9000AT laser scattering instrument (American Brookhaven). The average particle size of the nanoparticles in the product is in the range of 30-140nm, see attached table 3. The product can be stored in the form of sol in aqueous solution at 2-10°C.

[0027] Selenium concentration

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Abstract

The invention discloses a method for preparing nanometer monomer selenium via coupling liquid amino acid, comprising that at normal temperature and normal pressure, adding vitamin C solution into amino acid solution, mixing uniformly and adding selenious anhydride or selenite solution until the product has held red, to obtain the liquid coupled product of amino acid and nanometer selenium. The nanometer monomer selenium can be used as medical health-care product to display the cooperation between amino acid and nanometer selenium, while the nanometer selenium gel has small diameter, narrow distribution and liquid storage, to develop oral, injection or the like.

Description

technical field [0001] The invention relates to amino acid nano-selenium, in particular to a liquid-phase amino acid nano-selenium conjugate, as well as its preparation and storage methods. Background technique [0002] Selenium is an essential trace element for human body. Selenium has important biological functions such as anti-oxidation, regulating immunity, and antagonizing harmful heavy metals. Selenium deficiency in the human body will induce many diseases, such as AIDS, hepatitis B, liver cancer, Keshan disease, Kaschin-Beck disease, cardiovascular and cerebrovascular diseases, etc. At present, more than 40 countries and regions in the world are selenium-deficient or low-selenium. About 72% of the regions in China, 2 / 3 of the population live in low-selenium or selenium-deficient regions. From the northeast to the southwest, and from the eastern coast to the Qinghai-Tibet Plateau, there is a very wide selenium-deficient belt. The results of nutritional surveys in 13...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61K31/198A61K31/40A61P35/00A61P37/02
Inventor 郑文杰王自白燕张俊苓杨芳周艳晖
Owner JINAN UNIVERSITY
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