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Method for extracting and enriching saussurea involucrate total flavone

A technology of total flavonoids and snow lotus, applied in medical formulas, medical preparations containing active ingredients, plant raw materials, etc.

Inactive Publication Date: 2007-09-26
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Saussurea flavonoids after supercritical extraction are easier to release from the plant

Method used

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  • Method for extracting and enriching saussurea involucrate total flavone
  • Method for extracting and enriching saussurea involucrate total flavone
  • Method for extracting and enriching saussurea involucrate total flavone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Get dried 100g of snow lotus whole herb and pulverize it to 40 mesh and put it into a supercritical extraction kettle, start the supercritical carbon dioxide pump, and use supercritical CO 2 For pretreatment, set the extraction temperature to 30°C and use a small amount of CO 2 Exhaust the residual air in the system, then pressurize the extraction tank to 12MP, the temperature of the separation tank is 30°C, adjust the pressure of the separation tank to 4MP, and extract dynamically for 30 minutes;

[0051] After decompression and unloading, the residue in the extraction kettle was extracted with a conventional solvent method, and the residue was extracted with 7 times the amount of 50% ethanol solution at 30°C once for 1 hour each time. After filtering, the filtrate was combined, and the filtrate was concentrated to obtain The extract contains 3.15g of flavonoids;

[0052] Pretreatment of macroporous adsorption resin: Before using HPD type macroporous adsorption resin,...

Embodiment 2

[0055] Get dried 100g of snow lotus whole herb and pulverize it to 80 mesh and put it into a supercritical extraction kettle, start the supercritical carbon dioxide pump, and use supercritical CO 2 Substitute ethanol for pretreatment, set the extraction temperature to 40°C, and use a small amount of CO 2 Exhaust the residual air in the system, then pressurize the extraction tank to 20MP, the temperature of the separation tank is 40°C, adjust the pressure of the separation tank to 6MP, and extract dynamically for 60 minutes.

[0056] After decompression and unloading, 2.35 g of supercritical carbon dioxide snow lotus extract was obtained in the extraction kettle, and the residue after supercritical extraction was extracted twice at 60°C with 70% ethanol solution of 10 times the amount, each time for 2 hours, and combined after filtration Filtrate, after the filtrate was concentrated, 2.35 g of flavonoids in the extract was obtained; and 100 g of snow lotus of the same batch was...

Embodiment 3

[0060] Get dried 100g of snow lotus whole herb and pulverize it to 100 mesh and put it into a supercritical extraction kettle, start the supercritical carbon dioxide pump, and use supercritical CO 2 For pretreatment, set the extraction temperature to 45°C and use a small amount of CO 2 Exhaust the residual air in the system, then pressurize the extraction tank to 25MP, the temperature of the separation tank is 30°C, adjust the pressure of the separation tank to 4MP, and extract dynamically for 150 minutes;

[0061] After decompression and unloading, 2.41g of supercritical carbon dioxide snow lotus extract was obtained from the separation kettle, and the residue after supercritical extraction was extracted twice at 55°C with 7 times the amount of 70% ethanol, each for 3 hours, and the filtrate was combined after filtration After the filtrate was concentrated, 2.49g of flavonoids were obtained in the extract; while the crushed 100g snow lotus of the same batch was directly extra...

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Abstract

The invention discloses an extracting and enriching method of total flavone of saussurea involucrate, which is characterized by the following: proceeding supercritical CO2 extraction for saussurea involucrate; breaking cell wall in the decompressing course after supercritical extraction; reducing the resistance during mass transfer course; stripping low-polarity evaporating component to penetrate alcohol and plant component mutually; improving the extracting quantity by 37-120%.

Description

technical field [0001] The invention relates to a method for extracting and enriching total flavonoids of snow lotus Background technique [0002] Traditionally, the active ingredients of snow lotus are extracted directly with solvents. Solvent extraction requires a large amount of solvent and requires multiple long-term extractions. Due to limited extraction conditions, volatile and thermally decomposed components cannot be obtained, and active ingredients in deep layers are difficult to extract. The utilization rate of medicinal materials is poor. [0003] The method for extracting Saussurea flavonoids provided by the invention, first carries out supercritical CO 2 Extraction to obtain the volatile and thermally unstable components, and then extract with conventional solvents. Saussurea flavonoids after supercritical extraction are easier to release from the plant. The principle is: the decompression and degassing process after supercritical extract...

Claims

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Application Information

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IPC IPC(8): C07D311/30C07H17/07A61K36/285
CPCY02P20/54
Inventor 赵文军张富昌刘明灯高林
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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