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Novel base materials of cataplasm and its preparing method

A poultice and matrix technology, which is applied in the field of making poultices and substrates for various medical external patches, can solve the problems of inconspicuous ability of slow-release drugs, weak sticking force, poor moisturizing properties, etc. The effect of drug loading, no stimulation, and high permeability

Active Publication Date: 2010-05-12
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, many cataplasm bases have shortcomings such as weak poking force, poor moisture retention, poor gas permeability, and inconspicuous ability to release drugs. In order to overcome the shortcomings of the current cataplasm base, it is urgent to develop a cataplasm with excellent properties Patch matrix as the basic raw material for cataplasm production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Prescription and ratio:

[0034] Kabham 5.0g Gum Arabic 10.0g Glycerin 30.0g

[0035] Macrogol 400 5.0g Povidone K30 5.0g Povidone K90 15.0g

[0036] Gelatin 20.0g Sodium Hydroxide 2.0g Purified Water 95.0g

[0037] Preparation:

[0038] Mix 5.0g of carbomer with 10.0g of gum arabic; mix 30.0g of glycerin and 4005.0g of polyethylene glycol, add the mixture of carbomer and gum arabic, mix well, take sodium hydroxide and add appropriate amount of purified water to dissolve completely Add to the mixture and heat and mix to obtain phase I; take 5.0g of povidone K30, 15.0g of povidone K90, and 20.0g of gelatin and heat and mix to obtain phase II; heat and mix phases I and II , that is.

Embodiment 2

[0040] Prescription and ratio:

[0041] Kabham 2.0g

Gum Arabic 20.0g

Glycerin 20.0g

Polyethylene glycol 400 10.0g

Povidone K30 10.0g

Povidone K90 25.0g

Gelatin 10.0g

Sodium hydroxide 1.0g

Purified water 160.0g

[0042] Kabham 2.0g

Gum Arabic 20.0g

Glycerin 20.0g

Azone 4.0g

Camphor 2.0g

Menthol 2.0g

[0043] Preparation:

[0044] Mix 2.0g of carbomer with 20.0g of gum arabic; mix 20.0g of glycerin and 10.0g of polyethylene glycol 400, add the mixture of carbomer and gum arabic, mix well, take sodium hydroxide and add appropriate amount of purified water to dissolve completely Add to the mixture and heat and mix to obtain phase I; take 10.0g of povidone K30, 25.0g of povidone K90, and 10.0g of gelatin and heat and mix to obtain phase II; heat and mix phases I and II , add azone 4.0g, camphor 2.0g, menthol 2.0 and mix well to obtain.

Embodiment 3

[0046] Prescription and ratio:

[0047]Kabham 10.0g Gum Arabic 5.0g Glycerin 60.0g

[0048] Macrogol 400 3.0g Povidone K30 5.0g Povidone K90 5.0g

[0049] Gelatin 40.0g Sodium Hydroxide 4.0g Purified Water 80.0g

[0050] Azone 2.0g Capsicum Extract 5.0g

[0051] Preparation:

[0052] Mix 10.0g of carbomer with 5.0g of gum arabic; mix 60.0g of glycerin and 4003.0g of polyethylene glycol, add the mixture of carbomer and gum arabic, mix well, take sodium hydroxide and add appropriate amount of purified water to dissolve completely Add it into the mixture and heat and mix to obtain phase I; take 5.0 g of povidone K30, 5.0 g and 40.0 g of gelatin and heat and mix to obtain phase II; mix phase I and phase II, Stir and heat, add 2.0g of azone and 5.0g of capsicum extract and mix well to obtain.

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PUM

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Abstract

The invention provides a new-type cataplasma matrix and its preparing method. The formulation is: carbomer 2.0-10.0 shares, arabic gum 5.0-20.0 shares, glycerin 20.0-60.0 shares, Polyethylene Glyco 3.0-10.0 shares, polyvidone 10.0-40.0 shares, glutin 10.0-40.0 shares, sodium hydroxide 1.0-4.0 shares, ultrapure water 70.0-120.0 shares, azone 0.0-6.0 shares, camphor 0.0-5.0 shares, menthol crystal 0.0-5.0 shares, or azone 0.0-6.0 shares, capsicum extract 0.0-5.0 shares. The inventive cataplasma matrix has a good adhesive force to skin, a storage stability in a temperature and humidity change, agood compatibility with different medicine, a wide application area and fits for the free activity of the affected part and a high dosage medicine. The cataplasma matrix can be taken off and adhered again and again without pain and residue.

Description

technical field [0001] The invention relates to a novel cataplasm matrix and a preparation method of the cataplasm matrix. The cataplasm matrix relates to a matrix that can be used for making cataplasms and various external medical patches. Background technique [0002] Transdermal drug delivery system is the frontier direction in the current pharmaceutical field, and drug absorption through the skin has many advantages. Traditional plasters (soft plasters, black plasters) are all based on fat-soluble materials, which have serious defects in application, such as small drug load, poor transdermal performance, allergies, rashes, adhesion of hair, and contamination of clothing. At that time, the medical circles in Europe and Japan were all committed to improving the traditional external patch, and tried to develop a kind of patch with large drug content, good transdermal effect, controllable and slow release of drug components, good air permeability, and no irritation to the sk...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/46A61K47/42A61K47/34A61K47/10
Inventor 马莉韩锋
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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