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Chrisma for vaginal containing tioconzole and its preparation method

A technology of tioconazole and ointment, applied to vaginal ointment containing tioconazole and its preparation, in the field of medicine, can solve the problems of difficulty in grasping technical control points and high cost, and achieves easy implementation of the production process, small systemic absorption, and high cost. powerful effect

Inactive Publication Date: 2007-10-24
SHANGHAI GOLDEN PHARMATECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the product has not been marketed in the domestic market. The main reasons are as follows: 1. The cost of the existing formula and production process is relatively high; 2. The particularity of tioconazole raw materials makes it difficult to grasp the key technical control points

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] formula:

[0017] Tioconazole 300mg

[0018] Vaseline 3500mg

[0019] Liquid paraffin 500mg

[0020] Ethylparaben 0.1mg

[0021] Preparation:

[0022] The tioconazole is crushed to a powder between 10 μm and 50 μm, mixed with the formulated amount of vaseline and liquid paraffin, and stirred evenly, and finally ethylparaben is added and stirred evenly.

Embodiment 2

[0024] formula:

[0025] Tioconazole 300mg

[0026] White petrolatum 4000mg

[0027] Liquid paraffin 300mg

[0028] BHA 0.1mg

[0029] Preparation:

[0030] Grind tioconazole to a powder between 10 μm and 50 μm, mix and stir evenly with the formula amount of white petrolatum and liquid paraffin, and finally add BHA (tert-butyl-4-hydroxyanisole) and stir evenly.

Embodiment 3

[0032] formula:

[0033] Tioconazole 300mg

[0034] Vaseline 4300mg

[0035] Ethylparaben 0.1mg

[0036] Preparation:

[0037] The tioconazole is ground to a powder between 10 μm and 50 μm, mixed with the formulated amount of petrolatum and stirred evenly, and finally ethylparaben is added and stirred evenly.

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PUM

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Abstract

The invention relates to a tioconazole-containing paste for vaginal use, comprising tioconazole and medical findings. The weight of tioconazole is 5-8% of total weight of paste, and the left is findings. The tioconazole is distributed in medical findings. The invention also discloses the method for preparing said paste, which includes a step of distributing tioconazole into medical findings. The step comprises: disintegrating tioconazole into powder particular with diameter being 10 um-50 um, mixing medical findings with tioconazole powder particular, adding conservative and stirring. The invention is characterized by easy performance for paste formulation and production process, the dissolving property of tioconazole is improved through disintegration, so the production is reduced and process is simplified. The product can be used to resist fungus and treat vagina fungus infection.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a medicine, in particular to a vaginal ointment containing tioconazole and a preparation method thereof. Background technique [0002] Tioconazole is a new generation of imidazole antifungal drugs with strong efficacy and broad antibacterial spectrum. Its biggest feature is that it is difficult to absorb through the skin or mucous membranes. Therefore, it has almost no systemic effect when used as a local drug, thus avoiding some toxic and side effects. [0003] Tioconazole was first developed by Pfizer, which filed a patent application for tioconazole in the United States in 1975, with the patent number US4062966. And in 1985 applied for the patent of tioconazole composition, the patent number is US717423. The patent covers 100mg oral tablets, 1% and 2% creams, 6.5% ointment and 100mg vaginal tablets. [0004] Pfizer's topical tioconazole product was approved as an OTC product (NDA18,682...

Claims

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Application Information

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IPC IPC(8): A61K31/4178A61K9/06A61P31/10
Inventor 刘兰芳
Owner SHANGHAI GOLDEN PHARMATECH
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