Unlock instant, AI-driven research and patent intelligence for your innovation.

Improved entecavir effervescent tablet and its preparation method

A technology of entecavir and effervescent tablets, which is applied in the field of medicine and its preparation, can solve the problems of low mutation rate and achieve the effects of high bioavailability, less intestinal residue, and convenient administration

Inactive Publication Date: 2007-10-24
SUNSHINE LAKE PHARM CO LTD
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Viral mutations caused by entecavir treatment only occurred in patients infected with lamivudine-resistant mutant virus strains, and the mutation rate was low (5.8%)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Improved entecavir effervescent tablet and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] prescription:

[0032] Entecavir 0.5g

[0033] Sucrose 490g

[0034] Tartaric acid 5g

[0035] Sodium bicarbonate 5g

[0036] Disodium Glycyrrhizinate 5g

[0037] Orange essence 0.5g

[0038] Scarlet Red 0.25g

[0039] Talc powder 5g

[0040] A total of 1000 pieces were made

[0041] Preparation method: mix entecavir powder (200 mesh) and sucrose powder (150 mesh) in equal increments; pass the remaining auxiliary materials through a 200 mesh sieve, and mix in equal increments; add raw materials and sucrose mixed powder, After mixing evenly according to the method of equal increment, directly compress into tablets.

Embodiment 2

[0043] prescription:

[0044] Entecavir 0.25g

[0045] Lactose 190g

[0046] Citric acid 5g

[0047] Sodium carbonate 5g

[0048] Aspartame 50g

[0049]Glycyrrhizin 2.5g

[0050] Peach Flavor 2.5g

[0051] Orange 0.12g

[0052] Micronized silica gel 2.5g

[0053] A total of 1000 pieces were made

[0054] Preparation method: Entecavir powder (200 mesh) and lactose powder (150 mesh) are mixed uniformly in equal increments; after the remaining excipients are passed through a 200 mesh sieve, equal increments are mixed uniformly; added raw materials and lactose mixed powder, After mixing evenly according to the method of equal increment, directly compress into tablets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an entecavir effervescent tablet treating hepatitis B and the preparing method. It is characterized by fast disintegration and absorption, high biological utilization rate, convenient usage, little residue in intestinal canal and small side effect. The product takes entecavir as raw material, and also comprises specific findings.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a preparation method and application of entecavir effervescent tablets for treating various hepatitis. Background technique [0002] Chronic hepatitis B is a serious disease caused by hepatitis B virus HBV, and it is also one of the diseases with high morbidity and mortality in the world. The virus can cause lifelong infection, liver fibrosis or cirrhosis, liver cancer, liver failure and death. According to the US Centers for Disease Control and Prevention, about 1.25 million people in the United States are infected with HBV virus, and more than 5,000 people die from hepatitis B and HBV infection-related diseases every year, and there are 100,000 new cases every year; about 100 people in Europe every year 10,000 to 2 million people are infected with HBV, of which about 90,000 people are persistently infected, and about 22,000 people eventually die of liver cirrhosis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K9/20A61K9/46A61K47/28A61P1/16A61P31/20
Inventor 文力奇
Owner SUNSHINE LAKE PHARM CO LTD