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Medicinal composition containing epimedium active constituent and its application

A technology of epimedium extract and composition, applied in the direction of medical preparations containing active ingredients, drug combinations, organic active ingredients, etc.

Active Publication Date: 2007-10-24
BRIGHT FUTURE PHARMA LAB LTD (CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] This patent is to solve the following technical problems: on the basis of existing patents, to demonstrate the inhibition of benign prostatic hyperplasia and prostatic inflammation, so as to prove the pharmacological effects of Epimedium extract and its active ingredients, and prepare a pharmaceutical composition with definite curative effect for preventing and treating benign prostatic hyperplasia

Method used

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  • Medicinal composition containing epimedium active constituent and its application
  • Medicinal composition containing epimedium active constituent and its application
  • Medicinal composition containing epimedium active constituent and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of Epimedium Extract

[0027] Epimedium leaf coarse powder is used 500g, extracts 3 times (60 ℃) with 3 liters of 60% ethanol solution, extraction time is 2 hours, filters and merges extraction liquid, reclaims organic solvent under reduced pressure, and aqueous solution adds macroporous adsorption resin (D101 or D140 column, wet weight 1000g), elute with 3 liters of water, then elute with 30%-85% ethanol solution, recover the ethanol eluate under reduced pressure, and dry to obtain 20g of part A extract (i.e. Epimedium extract of the present invention) , The yield is 3%, and the content of icariin in the extract of part A is determined to be 20%, and the total flavonoid content of Epimedium is 45.8%.

[0028] Take 400 g of the above Epimedium extract, repeat silica gel column chromatography, and perform chloroform:methanol gradient elution as usual (gradient elution refers to gradually increasing the methanol content in chloroform), thereby obtaining four c...

Embodiment 2

[0039] Preparation of Common Capsules of Epimedium Extract

[0040] Take Example 1 Epimedium extract 200g, microcrystalline cellulose (filler), sodium carboxymethyl starch (disintegrant) and pass through a 60-mesh sieve and mix evenly, add an appropriate amount of polysorbate 80 (wetting agent), Add 3% hydroxypropyl methylcellulose (E5 type is the binder) aqueous solution to prepare soft material in an appropriate amount, pass through a 20-mesh sieve and granulate. 40-50 ℃ oven blast drying. The dry granules are passed through a 20-mesh sieve for granulation, and the prescribed amount of talcum powder is added and mixed evenly. Fill No. 1 capsules according to the prescribed amount, and make 1000 capsules, each containing 200 mg of Epimedium extract. Usage: Three times a day, two capsules each time.

Embodiment 3

[0042] Preparation of Icariin Ordinary Tablets

[0043] Take 1 icariin, lactose (filler), and hydroxypropyl cellulose (disintegrating agent) of Example 1 and pass through a 60-mesh sieve and mix evenly, add an appropriate amount of polysorbate 80 (wetting agent), add 3% hydroxypropyl cellulose A proper amount of methylcellulose E5 (binder) aqueous solution is used to make soft materials, and granulated through a 20-mesh sieve. 40-50 ℃ oven blast drying. The dry granules are sieved through a 20-mesh sieve, added the prescribed amount of talcum powder, mixed evenly, and pressed into tablets to make 1000 granules, each containing 200 mg of icariin extract. Suggested taking method and dosage range: 4-8 capsules / day.

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Abstract

The invention relates to a medicine compound for preventing and treating prostatic hyperplasia. The raw material comprises carriin, carriin I, epimidin A, Sagittate carriin A and their mixture which are separated from barren wort extract. The invention also discloses the application of barren wort extract in preparing medicine for preventing and treating prostatic hyperplasia and prostatitis, preventing prostatitis hyperplasia or inhibiting hyperplasia deltoid muscle contract.

Description

technical field [0001] The invention relates to the activity of the epimedium extract and its active ingredients in inhibiting prostate hyperplasia and the preparation of medicine for treating prostate hyperplasia. Background technique [0002] Epimedium is a plant of the genus Epimedium in the family Berberidaceae. There are five species in the collection of "Chinese Pharmacopoeia": E. brevicornum, E. sagitatum, E. pubescens, E. wushanense and E. icoroanum . The source of raw materials of the currently used epimedium extracts all come from these five plants. Epimedium is a commonly used traditional Chinese medicine. Traditional Chinese medicine is used to invigorate the kidney and strengthen yang, and mainly treat impotence, nocturnal emission, urinary frequency and incontinence, etc. It is recorded in the ancient book "Materia Medica": "Epimedium strengthens the kidney yang and facilitates urination. It refers to the elderly and people with weak kidney yang and those w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P13/08A61P13/10
Inventor 董辉
Owner BRIGHT FUTURE PHARMA LAB LTD (CN)
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