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Medicine composition

A technology of composition and medicine, which is applied in the field of compound traditional Chinese medicine pharmaceutical composition, and can solve the problems of unretrieved organic acids of honeysuckle, compatible application of baicalin and total glycosides of gardenia, low content of effective components, rough raw materials of honeysuckle extract, etc.

Inactive Publication Date: 2007-11-07
PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the Yinhuang preparation has a certain curative effect in clinical practice, the drug uses the original medicinal materials for compatibility and is prepared into a preparation through simple extraction. Therefore, Chinese patients in the process of use found that the preparation has certain defects: (1) Yinhuang injection The effective components in the liquid and Yinhuang oral liquid are honeysuckle extract and baicalin. The raw material of honeysuckle extract is rough, the quality uniformity is poor, and the stability of the two in aqueous solution is poor, resulting in product quality in the process of storage, transportation and use. There will be great changes, so the curative effect is unstable in clinical application, and the quality is not uniform, causing doctors to doubt the use of drugs; (2) The effective components in Yinhuang tablets, buccal tablets and capsules are honeysuckle crude extract and baicalin , the honeysuckle medicinal material is simply extracted from the honeysuckle extract, the content of active components is low, the quality between batches is uneven, and the curative effect is unstable
[0006] Checking the literature and patents, no compatible application of honeysuckle organic acid, baicalin and total glycosides of gardenia was found

Method used

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  • Medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0143] Oral raw materials: 75 grams of honeysuckle organic acid, 75 grams of baicalin, 15 grams of total gardenia glycosides; pharmaceutical excipients;

[0144] The raw materials for injection are: honeysuckle organic acid 37.5g, baicalin 37.5g, gardenia total glycosides 7.5g; medicinal excipients;

[0145] Extraction process:

[0146] (1) Take honeysuckle, add water and reflux for extraction 2 times, 15 minutes each time, filter the extract, combine the filtrate, concentrate, adjust the pH value of the aqueous solution to 1 with hydrochloric acid, and then extract 3 times with ethyl acetate. The amount is 1.5 times, 1.2 times, 1.0 times the amount of the water phase. Combine the ethyl acetate layers, concentrate to an extract, add an equal volume of ethanol, mix, and vacuum dry to obtain honeysuckle organic acid and honeysuckle organic acid chlorogenic acid content 20%, 3,5-dicaffeoylquinic acid content is 10%, 3,4-dicaffeoylquinic acid content is 20%, honeysuckle organic acid c...

Embodiment 2

[0164] Oral raw materials: 150 grams of honeysuckle organic acid, 180 grams of baicalin, 75 grams of total gardenia glycosides; pharmaceutical excipients;

[0165] The raw materials for injection are: 75 grams of honeysuckle organic acid, 90 grams of baicalin, 37.5 grams of gardenia total glycosides; pharmaceutical excipients;

[0166] Extraction process:

[0167] (1) Take honeysuckle, add water and reflux for extraction 4 times, 40 minutes each time, filter the extract, combine the filtrate, concentrate, adjust the pH of the aqueous solution to 2 with hydrochloric acid, and extract 3 times with ethyl acetate. The amount is 1.5 times, 1.2 times, 1.0 times the amount of the water phase. Combine the ethyl acetate layers, concentrate to an extract, add an equal volume of ethanol, mix, and vacuum dry to obtain honeysuckle organic acid and honeysuckle organic acid chlorogenic acid content 55%, 3,5-dicaffeoylquinic acid content is 20%, 3,4-dicaffeoylquinic acid content is 20%, honeysuck...

Embodiment 3

[0185] Oral raw materials are: 100 grams of honeysuckle organic acid, 120 grams of baicalin, 45 grams of total gardenia glycosides; pharmaceutical excipients;

[0186] Oral raw materials are: 50 grams of honeysuckle organic acid, 60 grams of baicalin, 22.5 grams of gardenia total glycosides; pharmaceutical excipients;

[0187] Extraction process:

[0188] (1) Take honeysuckle, add water and reflux for extraction 3 times, 30 minutes each time, filter the extract, combine the filtrate, concentrate, adjust the pH value of the aqueous solution to 1.5 with hydrochloric acid, and extract 3 times with ethyl acetate. It is 1.5 times, 1.2 times and 1.0 times the amount of the water phase. Combine the ethyl acetate layers, concentrate to extract form, add an equal volume of ethanol, mix, and vacuum dry to obtain honeysuckle organic acid. The honeysuckle organic acid is in green The original acid, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid accounted for 84.3%; the organic acid chlo...

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Abstract

The present invention discloses one kind of medicine composition and features that the medicine composition includes organic acid of honeysuckle, total jasminoidin and baicalin as the effective components. Scientific quality control method and dissolution measuring method are established, and the recipe and dosage of the medicine composition are determined by means of bactreiostasis, antiviral, antiphlogistic and other pharmacodynamic experiments. Pharmacological experiment shows that the medicine composition of the present invention has excellent pharmacological effect.

Description

Technical field [0001] The present invention relates to the technical field of traditional Chinese medicine, in particular to a compound traditional Chinese medicine pharmaceutical composition containing honeysuckle organic acid, baicalin and total glycosides of gardenia. [0002] The organic acids and total glycosides of honeysuckle, the effective part of the components of this application, can be prepared by the process of this application, or can be obtained by literature or patent methods, including commercially available; baicalin in this application is obtained according to literature or patent methods, including market Sale. Background technique [0003] Yinhuang preparations are selected after years of clinical practice, and their clinical application has shown the efficacy of clearing away heat, detoxifying and anti-infectives. Traditional Chinese medicine Yinhuang preparations (Yinhuang capsules, Yinhuang buccal tablets, etc.) and Yinhuang liquid preparations (Yinhuang ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K9/20A61K9/48A61K9/16A61K9/08A61K9/10A61K9/14A61K9/50A61P31/04A61P11/04A61P29/00A61P31/12A61P9/00A61P1/16A61K36/35A61K36/539
Inventor 顾群李志刚魏俊玲郭小鹏渠守峰米长江阮爱华金治刚林治荣刘严曹艳芳
Owner PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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