Prulifloxacin and its key intermediate NM441 preparing method
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- 亚邦化工集团有限公司
- Publication Date
- 2007-11-14
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
Technical field:
[0001] The invention relates to a new method for preparing fluoroquinolone antibacterial drug prulifloxacin and its key intermediate NM441 Background technique:
[0002] Quinolones antibacterials are rapidly developing anti-infectives this year, accounting for 18.5% of the world's antibiotic market, with an average annual growth rate of 7%, and are one of the most active areas in the development of anti-infectives. Its development is divided into four stages: the first stage is the initial stage of development, and the products are nalidixic acid and pipemidic acid, which have only moderate antibacterial activity, and their pharmacokinetics and safety are not satisfactory. At present, they are basically eliminated. From the second stage, quinolones entered a period of rapid development, and their comprehensive clinical curative effect on Gram-negative bacteria has surpassed that of penicillins, reaching the effect of the first and second generation cephalosp...