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Porous biomaterial-filler composite and a method for making the same

A technology of biomaterials and composites, applied in the field of inorganic collagen scaffolds

Inactive Publication Date: 2007-12-05
AGENCY FOR SCI TECH & RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, no implants or collagen sponges have achieved the same or similar properties as natural bone

Method used

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  • Porous biomaterial-filler composite and a method for making the same
  • Porous biomaterial-filler composite and a method for making the same
  • Porous biomaterial-filler composite and a method for making the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A

[0140] The following examples describe the preparation of hydroxyapatite that can be used in the present invention. The hydroxyapatite in this method is prepared by a sol-gel method.

[0141] Use the following raw materials:

[0142] Ca(NO 3 ) 2 .4H 2 O mw = 236.15

[0143] (NH 4 ) 2 HPO 4 mw=132.06

[0144] Add 0.05M~0.5M calcium nitrate Ca(NO 3 ) 2 .4H 2 O dissolves in dH 2 Prepare the first solution in O (heavy water). In addition, 0.05M~0.5M ammonium phosphate (NH 4 ) 2 HPO 4 Soluble in dH 2 O Prepare a second solution and add aqueous ammonia NH to it 4 OH, adjust the pH of the solution to 10. Then add the first solution dropwise to the second solution. The solution was then aged at room temperature for 100 hours, and a precipitate was obtained by centrifugation. Then use three parts of reduced concentration ammonia water NH 4 OH and dH 2 O rinse, followed by a second rinse with ethanol.

[0145] The resulting gel was air-dried on a watch glas...

Embodiment B

[0147] The following examples describe the preparation method of carbonate apatite used in the present invention. The mesocarbonate apatite in this method is prepared by the following sol-gel method.

[0148] Use the following raw materials:

[0149] Ca(NO 3 ) 2 .4H 2 O mw = 236.15

[0150] (NH 4 ) 2 HPO 4 mw=132.06

[0151] (NH 4 )HCO 3 mw=79.06

[0152] Add 0.05M~0.5M calcium nitrate Ca(NO 3 ) 2 .4H 2 O dissolves in dH 2 Prepare the first solution in O (heavy water). In addition, 0.05M~0.5M ammonium phosphate (NH 4 ) 2 HPO 4 , 0.05M~0.5M ammonium carbonate (NH 4 )HCO 3 and an appropriate surfactant dissolved in dH 2 O Prepare a second solution. Add ammonia NH to the solution 4 OH and adjust the pH of the solution to 10. The first solution was then added dropwise to the second solution. The solution was aged at room temperature for 100 hours and the precipitate was obtained by centrifugal filtration. Then use three parts of reduced con...

Embodiment 1

[0155] Figure 1 shows a schematic diagram of the preparation of a scaffold according to one embodiment of the present invention. In this embodiment, type 1 collagen is used, as shown in FIG. 2 . Figure 2 is a set of scanning electron micrographs of dried collagen used in the present invention, shown at x120 and x2.3 resolution. The microstructure shows small fibers of about 1.5-2 microns in diameter mixed with the flakes.

[0156] As shown in FIG. 1 , collagen type 1 and phosphoric acid are mixed into a slurry and homogenized, and then calcium carbonate and / or apatite (such as HAP, FAP, CAP, or ZrCAP) are added to the slurry. The slurry is then homogenized so that the calcium phosphate and / or apatite are dispersed and deposited on the collagen fibers.

[0157] The slurry was then lyophilized and crosslinked to form a spongy foam. The lyophilized product can be cross-linked by the following protocol:

[0158] 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide / N-hydroxysuccinim...

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Abstract

A porous biomaterial-filler composite comprising a biomaterial, such as collagen, interspersed with a calcium phosphate-type filler material. The porosity of the composite is similar to that of natural bone, and pore size ranges from a few nanometers to greater than 100 microns. Brackets prepared from the biomaterial-filler composite are suitable for resorbent bone substitute materials.

Description

technical field [0001] The present invention relates to porous biomaterial-filler composites, their preparation and use. In a specific embodiment, the present invention relates to inorganic collagen scaffolds. Background technique [0002] Between 30% and 35% of bone is composed of organic material (on a dry weight basis). Approximately 95% of this organic material is collagen. The remaining organic ingredients are chondroitin sulfate, keratin sulfate, and phospholipids. Between 65% and 70% of bone is composed of inorganic substances. Almost all of these inorganic substances consist of hydroxyapatite. [0003] When a large amount of bone loss needs to be replaced, multiple grafts or permanent alloy implants are usually used to achieve this. Sometimes these grafts and implants do not perform as desired because they do not provide sufficient strength to a living organism or do not have sufficient biological activity to promote cell attachment and proliferation. Many of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/24A61L27/44A61L27/56
CPCA61L27/446A61L27/58A61L27/46A61L27/56C08L89/06
Inventor 应仪如舒纳·派克高舒军穆罕默德·沙里夫·穆罕默德·艾尔沙德毛佩琳
Owner AGENCY FOR SCI TECH & RES