Medicine in use for treating gastric cancer, and preparation method

A drug and gastric cancer technology, which is applied in the field of drugs for the treatment of gastric cancer and its preparation, can solve problems such as the impact of antibody activity, and achieve the effects of increasing intake, reducing impact, and enhancing stability
CN101091799AInactive Publication Date: 2007-12-26PEKING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
PEKING UNIV
Publication Date
2007-12-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a medicine for curing carcinoma of stomach and its preparation method. Said medicine includes antibody and radioactive nuclide. Said antibody is monoclonal antibody 3H11, said radioactive nuclide can utilize a bifunctional connecting agent to mark the described monoclonal antibody 3H11. Because the tumor cell surface can express specific antigen, so that it can utilize the specific combination of antibody and antigen, and can utilize antibody to make the radioactive nuclide be loaded on the tumor region, and utilize beta-particles released by radioactive nuclide decay to kill carcinoma cell so as to attain the goal of curing carcinoma.
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Description

technical field

[0001] The invention relates to a medicine for treating gastric cancer and a preparation method thereof. The medicine indirectly labels radionuclide to monoclonal antibody 3H11 through a bifunctional linker. Since the surface of tumor cells expresses a specific antigen, the specificity of the antibody and the antigen is utilized. Sexual binding, so that the labeled antibody concentrates on the tumor site after injection into the body, and uses the β released by the decay of the radionuclide - Particles kill cancer cells to achieve the purpose of treatment. Background technique

[0002] Tumor is one of the major diseases that endanger human life and health. How to diagnose and treat early is the goal pursued by biomedical workers for a long time. Specific antigens are expressed on the surface of tumor cells, and monoclonal antibodies have the specificity of recognizing antigens, so monoclonal antibodies can be used to treat diseases. Due to the specificity a...

Claims

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