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Composite type emulsifier, and emulsion prepared by using the emulsifier, and preparation method

A compound emulsifier, emulsifier technology, applied in the field of medicine, can solve the problems of emulsion freezing and thawing

Inactive Publication Date: 2007-12-26
SHENYANG PHARMA UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The main means to solve the problem of emulsion freezing and thawing is the reasonable selection of emulsifier and oil phase composition
Our idea to solve such problems is to adjust the composition of the oil phase and the composition of the emulsifier with low toxicity. Our test results found that a reasonable selection of the composition of the emulsifier and the oil phase can solve the problem we mentioned in the "Technical Background". Five major problems with existing emulsions

Method used

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  • Composite type emulsifier, and emulsion prepared by using the emulsifier, and preparation method
  • Composite type emulsifier, and emulsion prepared by using the emulsifier, and preparation method
  • Composite type emulsifier, and emulsion prepared by using the emulsifier, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1: Investigate with HS 15 When SPC is used as a compound emulsifier, the effect of different ratios of soybean oil / medium chain oil as oil phase emulsion on particle size before and after freezing and thawing.

[0058] Prescription composition: Coenzyme Q 10 0.25g, soybean lecithin 1.2g, HS 15 0.9g, oil for injection 10g, glycerin 2.2g, and the rest water for injection, a total of 100mL.

[0059] The oil for injection is soybean oil / medium chain oil ratio of 100:0~0:100 (w / w)

[0060] 1. In the preparation tank, inject oil, phospholipid, HS 15 Heat to 50°C, stir until dissolved, add the drug, stir to dissolve;

[0061] 2. In the preparation tank, add glycerin into the water for injection, and stir at 50°C for 5 minutes to completely dissolve it.

[0062] 3. Add 2 to 1 under stirring conditions, and stir at 50°C to obtain colostrum. The resulting liquid is passed through a microfluidizer. The first step is to adjust the homogenization pressure to 4000psi, ...

Embodiment 2

[0067] Example 2: When TPGS and SPC were used as compound emulsifiers, different ratios of soybean oil / medium chain oil were used as oil phases to investigate the effect of particle size on the emulsion before and after freezing and thawing.

[0068] Prescription composition: Coenzyme Q 10 0.25g, soybean lecithin 1.2g, TPGS 1g, oil for injection 10g, glycerin 2.2g, and the rest water for injection, 100mL in total.

[0069] The oil for injection is soybean oil / medium chain oil ratio of 100:0~0:100 (w / w)

[0070] 1. In the preparation tank, heat the oil for injection, phospholipid, and TPGS to 50°C, stir until dissolved, add the drug, and stir to dissolve;

[0071] 2. In the preparation tank, add glycerin into the water for injection, and stir at 50°C for 5 minutes to completely dissolve it.

[0072] 3. Add 2 to 1 under stirring conditions, and stir at 50°C to obtain colostrum. The resulting liquid is passed through a microfluidizer. The first step is to adjust the homogeniza...

Embodiment 3

[0077] Example 3: To investigate the effect of different phospholipids on the particle size of the emulsion before and after freezing and thawing.

[0078] Prescription composition: Coenzyme Q 10 1.0g, phospholipids 1.2g, HS 15 3.0g, 10g of oil for injection (soybean oil / medium chain oil, 15 / 85, w / w), 5.0g of propylene glycol, 0.05g of EDTA-2Na, the rest is water for injection, 100mL in total.

[0079] 1. In the preparation tank, inject oil, phospholipid, HS 15 Heat to 80°C, stir until dissolved, add the drug, stir to dissolve;

[0080] 2. In the preparation tank, add propylene glycol and EDTA-2Na into the water for injection, and stir at 80°C for 5 minutes to dissolve them completely;

[0081] 3. Add 2 to 1 under the condition of stirring, and stir at 50°C to obtain colostrum. The obtained liquid is passed through a microfluidizer. The first step is to adjust the homogenization pressure to 5000psi, and the second step is to adjust it to 14000psi. Homogenize repeatedly t...

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Abstract

The invention belongs to the medicine area, which involves a multi-emulsifier and a emulsion which be used by the multi-emulsifier and can resist high temperature and low temperature. This multi-emulsifier can combine by two or more then three emulsifiers. When combining, we can use two or more then three emulsifiers at will. The multi-emulsifier includes pharmaceutic adjuvant, oil and water. The emulsion includes drugs, oil phase, multi-emulsifier, the water and so on. The emulsion can be made after combining the oil and the water by isotropic device. The invention has some advantages: 1, the emulsion can resist high temperature and frost thawing. 2, easy to produce the average granularity smaller than the 150nm. 3, obtains the aseptic preparation without the high temperature. 4, produces the emulsion under the low pH value, so expand the application area. 5, increases the chemical stability of the medicine. 6, reduces the irritating quality.

Description

Technical field: [0001] The invention relates to the technical field of medicines, and relates to a composite emulsifier, an emulsion capable of resisting high temperature and low temperature damage prepared by using the compound emulsifier, and a preparation method thereof. Background technique: [0002] Generally speaking, the composition of the emulsion includes "oil phase", "water phase" and "emulsifier". Since the conventional (classic or traditional) emulsion is an unstable system, it is easily affected by external conditions, such as freezing, vibration, etc. Operations such as shaking and high-temperature sterilization will cause particle size changes, or even demulsification and oil separation, resulting in significant changes in product quality, affecting curative effect, unexpected adverse reactions, and even scrapping, resulting in great losses. At present, most of the oil phases for the preparation of emulsions use long-chain fatty acid esters, such as soybean o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F17/00C09K23/00C09K23/14C09K23/42
CPCB01F17/0028A61K36/00A61Q19/00A61K8/553A61K8/06A61K2800/91A61K2800/21A61K8/90A61K9/1075B01F17/0064A61K8/86A61K8/347C09K23/14C09K23/42
Inventor 邓意辉赵静董晓辉石莉卢懿倪东敏赵宏伟
Owner SHENYANG PHARMA UNIVERSITY
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