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Phentolamine Mesylate freeze-dried powder injection preparation and preparation method thereof

A technology of phentolamine mesylate and freeze-dried powder injection, which is applied in the field of pharmacy, can solve the problems of slow action effect, large drug dosage and the like, and achieves the effects of convenient transportation, excellent appearance and low drug water content

Inactive Publication Date: 2008-01-09
上海复旦复华药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a phentolamine mesylate freeze-dried powder preparation and its preparation method, to solve the defects of large drug dosage and slow action effect in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of phentolamine mesylate freeze-dried powder injection (10mg / support)

[0028] Phentolamine Mesylate 10g

[0029] Mannitol 50g

[0030] Water for injection 500ml

[0031] A total of 1000 freeze-dried products were made

[0032] ① Preparation of liquid medicine:

[0033] Take by weighing the raw material phentolamine mesylate 10g of prescription quantity, add (1 / 3 prescription quantity) water for injection to dissolve, add the mannitol of prescription quantity, then add water for injection to total amount.

[0034] ② Sterile filtration: the medicinal solution in step ① is sterilized and filtered through a sterilizing filter (0.22 μm in pore size). Integrity test is carried out on the sterilizing filter before filtration, and the filtrate is subpackaged after intermediate inspection.

[0035] ③Treatment of controlled glass bottles: wash in a bottle washing machine, first immerse the controlled glass bottles in water for injection, after ultrasonic cleanin...

Embodiment 2

[0041] Preparation of phentolamine mesylate freeze-dried powder injection (10mg / support)

[0042] Phentolamine Mesylate 10g

[0043] Dextran 30g

[0044] Water for injection 500ml

[0045] A total of 1000 freeze-dried products were made

[0046] The preparation method is the same as in Example 1 except that the auxiliary materials are added.

Embodiment 3

[0048] Preparation of phentolamine mesylate freeze-dried powder injection (10mg / support)

[0049] Phentolamine Mesylate 10g

[0050] Glucose 50g

[0051] Water for injection 500ml

[0052] A total of 1000 freeze-dried products were made

[0053] The preparation method is the same as in Example 1 except that the auxiliary materials are added.

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PUM

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Abstract

The present invention discloses a phentolamine mesylate freeze-dried powder preparation and its preparation method. Said preparation contains the phentolamine mesylate as active component and pharmaceutically-acceptable carrier. Said preparation can be used for curing pheochromocytoma and preoperative preparation.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a phentolamine mesylate freeze-dried powder preparation and a preparation method thereof. Background technique [0002] Phentolamine mesylate is a short-acting nonselective alpha-blocker (α 1 、α 2 ), can antagonize the effect of adrenaline and norepinephrine in the blood circulation, make blood vessels dilate and reduce peripheral vascular resistance; antagonize the effect of catecholamines, and are used for diagnosis and treatment of pheocytoma. It has little effect; it can reduce peripheral vascular resistance, reduce cardiac afterload, decrease left ventricular end-diastolic pressure and pulmonary artery pressure, increase cardiac output, and can be used to treat heart failure. [0003] At present, most of the preparations of phentolamine mesylate are tablets, and the tablets must first pass through the gastrointestinal tract and then enter the blood system, and then enter the whole ...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/417A61K47/26A61P9/04
Inventor 汤恩彪江金墀
Owner 上海复旦复华药业有限公司
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