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Application of total flavonoid extract of bunge pricklyash leaves in anti-hypoxia

A technology of flavonoids and extracts from pepper leaves, applied in the field of food and medicine and health care, to achieve good therapeutic effect

Inactive Publication Date: 2019-10-15
LANZHOU UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the anti-hypoxia effect of the total flavonoids extract from Zanthoxylum bungeanum leaves

Method used

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  • Application of total flavonoid extract of bunge pricklyash leaves in anti-hypoxia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1. Preparation of tablets

[0027] Active ingredient: Zanthoxylum bungeanum leaf flavonoid extract, the total flavonoid content is 50%;

[0028] Preparation process: Take 12g of active ingredient, add 112.5g of microcrystalline cellulose and mix evenly, use 0.8% magnesium stearate as lubricant and 5% sodium carboxymethyl starch as disintegrant, using direct compression Tablets are made into tablets, each 250mg,

[0029] Make 100 pieces;

[0030] Usage and dosage: 3 times a day, 2-4 tablets each time, eat after meals.

Embodiment 2

[0031] Example 2. Preparation of granules

[0032] Active ingredient: Zanthoxylum bungeanum leaf flavonoid extract, the total flavonoid content is 75%;

[0033] Preparation process: Take 8 g of active ingredient, add 192 g of starch and mix evenly, use starch slurry with a mass concentration of 10-12% as a binder, wet granulation, pass through a 12-14 mesh sieve, and reduce at 65-75°C Press and dry, pelletize, and divide into 10 g bags to make 20 bags;

[0034] Usage and dosage: 3 times a day, 1 bag each time, eat after meals.

Embodiment 3

[0035] Example 3. Preparation of oral liquid

[0036] Active ingredient: Zanthoxylum bungeanum leaf flavonoid extract, total flavonoid content is 88%;

[0037] Preparation process: Take 12g of active ingredient, add appropriate amount of food additives (white sugar, potassium sorbate), dissolve and mix according to the formula ratio to make 1000 mL, sterilize and sub-package to make 100 bottles, 10 mL each;

[0038] Usage and dosage: 3 times a day, 1-2 bottles each time, eat after meals.

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Abstract

The invention provides a total flavonoid extract of bunge pricklyash leaves with anti-hypoxia activity. A rat adrenal pheochromocytoma PC12 cell experiment shows that the total flavonoid extract of the bunge pricklyash leaves has a protective effect on PC12 cell damages caused by hypoxia, the cell viability under the condition of improving the hypoxia is achieved, brain tissue damages caused by the hypoxia are alleviated, the obvious anti-hypoxia activity is achieved, the decrease of the cell viability under the hypoxic condition can further be significantly reversed, and therefore, the totalflavonoid extract can be used as an active substance for the preparation of anti-hypoxia drugs.

Description

Technical field [0001] The invention relates to the application of total flavonoids extracts of Zanthoxylum bungeanum leaves in anti-anoxia, belonging to the fields of food and medicine and health care. Background technique [0002] Hypoxia refers to a pathological process that causes abnormal changes in the metabolism, function, and morphology of the tissue due to insufficient oxygen supply or oxygen use in the tissue. Hypoxia can cause tissue damage and participate in the progression and deterioration of many diseases, such as myocardial infarction and cerebral infarction. Therefore, physical (such as mild hypoxic pretreatment) or chemical (drug administration) discovery of effective intervention is essential to prevent hypoxia-related diseases. Plant extracts and monomeric compounds have a protective effect in preventing hypoxia damage, such as quercetin (a flavonoid) and salidroside are typical representatives. According to reports, quercetin protects hippocampal neurons fr...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61P39/06
CPCA61K36/758A61P39/06
Inventor 强音杨军丽
Owner LANZHOU UNIVERSITY
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