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Traditional Chinese medicine dispersion tablet for treating coronary heart disease and angina pectoris and preparing process thereof

A technology for coronary heart disease angina pectoris and dispersible tablets, which is applied in the field of the treatment of cardiovascular system diseases, the treatment of coronary heart disease angina pectoris drugs and the preparation fields thereof, can solve the problems of poor accuracy, loss of effective active ingredients, microbial contamination, etc., and achieves reduction of damage and molding. Good sex, not easy to fragment effect

Inactive Publication Date: 2008-01-16
王卫东
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AI Technical Summary

Problems solved by technology

But in actual application, the granule product of this medicine still has some shortcomings and deficiencies, specifically manifested in: 1. Since the preparation method of Lemai granule adopts traditional technology, the temperature for drying the medicinal material and the fineness of pulverization There are no specific requirements, so that some effective active ingredients in the preparation are lost, resulting in a decrease in clinical efficacy; 2. The dosage of granules is large, and the bioavailability is low; 3. The content of the main drug in granules is not easy to control, and the accuracy of patients' taking is poor; 4. It is easy to cause microbial contamination in the process of production and storage

Method used

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Experimental program
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Embodiment

[0057] 1. Prescription:

[0058] Danshen 748.5g, Chuanxiong 374.25g, Chishao 374.25g, Safflower 374.25g

[0059] Rhizoma Cyperus 187.13g Woody Fragrance 187.13g Hawthorn 93.6g

[0060] Crosslinked PVP 160g CMS-Na 40g Microcrystalline Cellulose 140g Magnesium Stearate 8g

[0061] Micropowder silica gel 6g 95% ethanol 30-35ml

[0062] 2. Preparation method:

[0063] Mix the above-mentioned seven-flavored traditional Chinese medicine substances, add water and decoct three times, add 10 times the amount of water for the first time, and 8 times the amount for the second and third times, decoct for 1 hour each time, combine the decoctions, filter, and the filtrate is centrifuged Concentrate in a thin-film evaporator at a low temperature of 45-50°C to a clear paste with a relative density of 1.10-1.30, dry it under reduced pressure, and grind it into the finest powder; mix the obtained finest powder with 80g cross-linked PVP, 40g CMS-Na, 140g micro After mixing the crystalline ce...

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Abstract

The invention relates to a preparation method of the medicine for treating the angina pectoris of coronary heart disease, which takes the danshen root, szechwan lovage rhizome, red peony root, safflower, nutgrass galingale rhizome, putchuck and hawthorn fruit as materials, which are made to dispersed tablets by process steps of decoction, filtering, low temperature concentration, decompression drying, granulation, granule settling and pressing, compared with the traditional granule, the dispersant of the invention has advantages of good dispersion state, short disintegration time, fast drug dissolution, good clinical effect, high bioavailability, controllable quality standard, convenient medicine taking by patients and non microbial contamination during production and storage and transportation.

Description

technical field [0001] The content of the invention belongs to the technical field of preparation of medicines, and relates to a medicine for treating cardiovascular system diseases, especially angina pectoris of coronary heart disease and a preparation method thereof. Background technique [0002] Coronary heart disease is the abbreviation of coronary atherosclerotic heart disease. It is a disease that causes a series of clinical symptoms due to atherosclerosis in the arteries that supply myocardial blood and oxygen, causing stenosis or occlusion of the lumen, resulting in myocardial ischemic changes. Coronary heart disease Angina pectoris is the most common type of coronary heart disease. It is a clinical syndrome caused by temporary myocardial ischemia and characterized by episodic chest pain or chest discomfort. The pain can often radiate to the patient when the disease occurs. Left shoulder, neck pharynx or mandible, even life-threatening, seriously affects people's hea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61K9/20A61K47/38A61P9/10
Inventor 王卫东
Owner 王卫东
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