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Method for preparing high-purity hypocrellin B

A high-purity technology of hypocrellin B, which is applied in quinone separation/purification, organic chemistry, etc., can solve the problems of waste of resources, affecting the efficacy of drugs, and low purity of hypocrellin B, and achieves strong operability and extraction high rate effect

Active Publication Date: 2010-08-18
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, the existing methods for extracting hypocrellin B from bamboo fungus or bamboo yellow fungus, the purity of the extracted hypocrellin B is not high, resulting in a waste of resources and affecting the curative effect of the drug

Method used

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  • Method for preparing high-purity hypocrellin B
  • Method for preparing high-purity hypocrellin B

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] High-purity hypocrellin B is extracted according to the following steps:

[0026] 1) Rough extraction: Take 1.0Kg of bamboo red fungus medicinal material, crush it into a coarse powder, add 5 times the amount of 95% ethanol to reflux for 1 hour, let cool to room temperature, pour out the supernatant, add ethanol to the dregs and repeat the reflux extraction twice, Three ethanol extraction solutions before and after merging;

[0027] 2) Concentration and natural crystallization: transfer the ethanol extract into distillation bottles respectively, recover the ethanol to 2 / 3 of the original volume under reduced pressure, and let it stand for natural crystallization;

[0028] 3) Acid and alkali treatment: pour off the mother liquor, evaporate the ethanol as much as possible for the crystallization, wash the crystallization with 20°C purified water for 3 times, pour out the water liquid as much as possible, dissolve the water-insoluble matter in 1000ml of 0.5% sodium hydroxi...

Embodiment 2

[0031] High-purity hypocrellin B is extracted according to the following steps:

[0032] 1) Crude extraction: Take 1.0Kg of bamboo red fungus medicinal material, crush it into a coarse powder, add 20 times the amount of 75% ethanol and heat it under reflux for 4 hours, let it cool to room temperature, pour out the supernatant, add ethanol to the dregs and repeat the reflux extraction twice, Three ethanol extraction solutions before and after merging;

[0033] 2) Concentration and natural crystallization: transfer the ethanol extract into distillation bottles respectively, recover the ethanol to 2 / 3 of the original volume under reduced pressure, and let it stand for natural crystallization;

[0034] 3) Acid and alkali treatment: the above-mentioned crystals were washed 3 times with 80°C purified water, the water-insoluble matter was dissolved in 200ml of 10% potassium hydroxide solution, and extracted with chloroform until the organic phase was basically colorless, and the orga...

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Abstract

The invention relates to a preparation method of high purity hypocrellin B. The high purity hypocrellin B (the purity is higher than 90.0%) is extracted from medicinal materials bamboo parasitic fungus and hypocrellin through the technology of separation, crystallization, acid-alkali transformation, neutralization, washing, and exsiccation and production purity analysis. The extract can be produced into a plurality of dosage forms such as unguent, tincture, aerosol, tablet, capsule, injection and so on with large-scale application. The method of the invention has the advantages of high operability and high extraction, and the solvent employed is facilitative and inexpensive and free of pollution to environment.

Description

technical field [0001] The invention relates to a method for extracting Chinese medicinal materials, in particular to a method for extracting high-purity hypocrellin (purity greater than 90.0%) from bamboo red fungus or bamboo yellow fungus, and the application of high-purity hypocrellin B. Background technique [0002] Hypocretin B (HB) is an effective medicinal substance extracted from the bamboo yellow fungus Chinese medicinal material and prepared through processes such as separation, crystallization, washing, acid-base treatment, extraction, and drying. Its molecular structure is shown in Figure 1. Bamboo yellow fungus is a traditional parasitic medicinal fungus in my country. It usually parasitizes on the young stems, tender stems, and branches of bamboo. Fujian, Jiangxi, Hubei, Hunan and Japan in Asia. It has the effects of clearing heat and reducing phlegm, clearing heart and calming convulsions, relaxing tendons and activating collaterals, dispelling pain and disper...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C50/36C07C46/10C07C50/38
Inventor 严家定罗凡项迎春
Owner YUNNAN PHYTOPHARML
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