Chitosan polyvinyl alcohol gel rubber containing nano granule of hydroxyapatite, producing method and uses of the same

A technology of hydroxyapatite and polyvinyl alcohol, applied in the field of biomedical composite materials, can solve the problems of sudden drug release, drug sustained release time, weak gel strength, etc., to avoid organic chemical reagents and other harmful substances, The preparation conditions are simple and mild, and the effect meets the requirements of environmental protection

Active Publication Date: 2008-02-27
华山科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan and polyvinyl alcohol can form an injectable temperature-sensitive gel, which can be used for drug sustained release and tissue engineering, but the disadvantages are weak gel strength, drug burst release phenomenon and long drug sustained release time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Dissolve 200 mg of chitosan in a hydrochloric acid solution with a concentration of 0.1 mol / l to prepare a 2 wt% solution; disperse 100 mg of hydroxyapatite nanoparticles with a particle size between 100 and 500 nm in 1 ml directly After distilling water, add it to the chitosan solution and stir in an ice bath for 15 minutes; dissolve 200 mg of polyvinyl alcohol and prepare a 2wt% solution; add 84 mg of sodium bicarbonate to the polyvinyl alcohol solution and place it in the ice bath for 15 minutes. ; Then under constant stirring, the polyvinyl alcohol solution was slowly dropped into the chitosan hydrochloric acid solution under ice bath, stirred for 10 minutes, the pH of the mixed solution was 6.7. Finally, the solution was placed at a gel temperature of 37°C for 30 minutes to prepare a gel, and its strength was determined to be 160 Pa by a dynamic rheometer. The mass ratio of chitosan to polyvinyl alcohol in the gel is 1:1. Taking chitosan as a reference, the ...

Embodiment 2

[0028] Example 2: Dissolve 200 mg of chitosan in a hydrochloric acid solution with a concentration of 0.1 mol / l to prepare a 2 wt% solution; add 28 mg of CaCl 2 Dissolve in the chitosan solution and stir for 15 min in an ice bath; dissolve 100 mg of polyvinyl alcohol and prepare a 1 wt% solution; add 84 mg of NaHCO 3 And 57mgNa 3 PO 4 ·12H 2 O (or corresponding amount of anhydrous Na 3 PO 4 ) Add the polyvinyl alcohol solution and place it in an ice bath for 15 minutes; then slowly drip the polyvinyl alcohol solution into the chitosan hydrochloric acid solution under constant stirring and ice bath, and stir for 10 minutes. The pH of the mixed solution is 6.8. Finally, the solution was placed at a gel temperature of 37°C for 30 minutes to prepare a gel, and its strength was determined by a dynamic rheometer to be 530Pa. The mass ratio of chitosan to polyvinyl alcohol in the gel is 2:1. Taking chitosan as a reference, the mass ratio of hydroxyapatite nanoparticles to chitosan in the...

Embodiment 3

[0029] Example 3: Dissolve 400 mg of chitosan in a hydrochloric acid solution to prepare a 4 wt% solution; add 56 mg of CaCl 2 Dissolve in the chitosan solution and stir for 15 minutes in an ice bath; dissolve 100 mg of polyvinyl alcohol and prepare a 1 wt% solution; add 168 mg of NaHCO 3 And 114mgNa 3 PO 4 ·12H2 O was added to the polyvinyl alcohol solution and placed in the ice bath for 15 minutes; then slowly drip the polyvinyl alcohol solution into the chitosan hydrochloric acid solution under the ice bath under constant stirring, and stir for 10 minutes. The pH of the mixed solution was 7.0. Finally, the solution was placed at a gel temperature of 37°C for 30 minutes to prepare a gel, and its strength was determined by a dynamic rheometer to be 590Pa. The mass ratio of chitosan to polyvinyl alcohol in the gel is 4:1. Taking chitosan as a reference, the mass ratio of hydroxyapatite nanoparticles to chitosan in the gel is 1:4.

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Abstract

The invention discloses a chitose/polyvinyl alcohol composite gel with hydroxyapatite nanometer particle and making method and application, which comprises the following parts: hydroxyapatite nanometer particle, chitose and polyvinyl alcohol, wherein the weight of chitose and polyvinyl alcohol is between 1: 20 and 8: 1 and the weight of hydroxyapatite nanometer particle and chitose is between 0. 5: 1 and 2: 1. The invention provides two making method of the composite gel, including directly adding method and original position generating method. The composite gel can be drug carrier to release sensitive drug slowly and injecting medical material to repair articular cartilage and organize engineering rack material, which can be applied in the cell culture.

Description

Technical field [0001] The invention relates to a chitosan / polyvinyl alcohol gel containing hydroxyapatite nanoparticles and a preparation method and application thereof, belonging to the field of biomedical composite materials. Background technique [0002] Hydrogels have been widely used in drug release and tissue engineering due to their good biocompatibility, swelling properties and non-inactivation of drug loading. According to different connection methods, hydrogels can be divided into chemical gels and physical gels. The chemical gel is formed by forming a covalent bond through a chemical reaction under the action of a chemical crosslinking agent or initiator, and the remaining chemical crosslinking agent or initiator after its formation has certain toxicity. Physical gels interact through non-covalent bonds, avoiding the use of chemical solvents, and are therefore popular. [0003] In recent years, the in-situ gel system has received widespread attention because it can be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L31/10A61K47/36
Inventor 杜予民汤玉峰李艳
Owner 华山科技股份有限公司
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