35results about How to "Simple and mild preparation conditions" patented technology

The invention discloses a chitose/polyvinyl alcohol composite gel with hydroxyapatite nanometer particle and making method and application, which comprises the following parts: hydroxyapatite nanometer particle, chitose and polyvinyl alcohol, wherein the weight of chitose and polyvinyl alcohol is between 1: 20 and 8: 1 and the weight of hydroxyapatite nanometer particle and chitose is between 0. 5: 1 and 2: 1. The invention provides two making method of the composite gel, including directly adding method and original position generating method. The composite gel can be drug carrier to release sensitive drug slowly and injecting medical material to repair articular cartilage and organize engineering rack material, which can be applied in the cell culture.

The invention belongs to the technical field of detection and relates to a portable arginine detection device and method. An AuNPs/CQDs fluorescent probe is fixed to filter paper, a paper-based nanometer fluorescent sensor is prepared, a laser in the length of 420 nm is adopted as an excitation wavelength standard in a dark room, and fluorescent signals on the paper-based sensor are directly readby an image collecting device; a fluorescence detection application in the image collecting device is adopted for converting chrominance components of fluorescent images into grayscale components on the basis of a grayscale model, then data processing is carried out, fitting of a grayscale-concentration fitting curve is achieved, and arginine is detected quickly, sensitively and conveniently. Therequirement for a demanded detection environment is low, and detection can be completed at the room temperature without other additional conditions. The portable arginine detection method is high in repeatability, does not require operation of correlated professional staff and can better meet the demands of the market and companies.

The invention relates to a therapy diagnosis preparation based on a polypyrrole compound and a preparation method of the preparation. The prepared polypyrrole preparation possesses both ultrasound contrast diagnosis function and photo-thermal therapy function, successively combines real time, high efficiency, low cost, no radiation and other characteristics of ultrasound contrast diagnosis and high selectivity and high curative effect of near-infrared photo-thermal therapy , helps to substantially increase the diagnosis-therapy efficiency, and has extremely good clinical application potential.

The invention provides a preparation method of citral Pickering emulsion stabilized with modified corn starch. The corn starch sold in the market is used as a raw material, and through esterificationand modification of octenyl succinic anhydride and freeze drying, the modified corn starch is obtained; and modified corn starch powder dissolves in a citric acid-sodium citrate acid buffer solution of which the pH is 3, under high-speed homogenizing, citral and medium-chain triglyceride are added, and the citral Pickering emulsion is prepared. The citral Pickering emulsion prepared by the preparation method disclosed by the invention is simple and mild in preparation condition, has the characteristics of being natural, environmentally-friendly and the like in raw materials, and good in stability, and the degradation of the citral under acid condition can be effectively relieved.

The invention discloses preparation and application of continuous cropping peanut resistant complex bacteria. The complex bacteria comprise continuous cropping peanut resistant bio-control bacteria and an allelochemicals degrading bacteria agent. By using the complex bacteria, the degradation efficiency of the continuous cropping peanut allelochemicals is high, the disease of continuous cropping peanuts can be effectively inhibited, and the using amount of chemical pesticides and the accumulation of the continuous cropping peanut in the soil can be reduced; in addition, the complex bacteria are significant in environment pollution; because the degraded product can be used as a carbon source by the bacteria and is converted into a harmless substance, and the carbon source of the soil is increased, so that the absorption of the crop root system to degradable substances is facilitated, and the pollution to the environment is avoided; the complex bacteria is high in stability; gene mutation is avoided after continuous culturing, the inheritance can be stabilized, the quantity of beneficial bacteria in the soil can be increased, and the soil fertility is increased; moreover, the preparation method of the complex bacteria is simple and an extraction process of the complex bacteria is simple; in addition, toxic substances are not added in the preparation process, and the complex bacteria are easy to use; the quality and the yield of crops such as peanuts in China can be improved.

The invention relates to a preparation method of a high-density metal azide with arbitrarily regulated filling density, and belongs to the field of initiating explosive devices. The preparation methodmixes hollow microspheres with different diameters constructed by nanoporous metal/metal oxide and fills a restraint shell with the hollow microspheres to prepare hollow microspheres constructed by the nanoporous metal/metal oxide with a little filling density in the restraint shell, and then places the restraint shell filled with the hollow microspheres constructed by the nanoporous metal/metaloxide in a reactor to be subjected to gas-solid in-situ chemical reaction with hydrazoic acid gas to prepare the metal azide with high filling density. The preparation method of the invention can prepare the high-density metal azide having a filling density of 50%-92% of theoretical density in the restraint shell. The prepared high-density metal azide (for example, the copper azide dose is more than or equal to 0.4 mg) in a single restraint shell can detonate HNS-IV, CL-20, PETN, RDX and other explosives with a filling density being 75%-92% of the theoretical density and a diameter being morethan or equal to 0.5 mm or ignite B/KNO3 and other ignition powder.

The invention discloses an antitumor slow-release implant having strong adhesion and hemostasis functions and a preparation method thereof. Inspired by mussel adhesion mechanism and catechol and iron ion chelating mechanism, postoperative thermal chemotherapy hydrogel based on mussel adhesion mechanism deriving is developed successfully through bionic design and serves as a multifunctional operative tissue adhesion and treatment agent. Main ingredients of the implant include chitosan, gallic acid, Fe3+ chelating agent and drug. Coating and treating of a wound can be performed by covalently crosslinking and freeze-drying chitosan and gallic acid, dissolving before use, adding antitumor drug, utilizing the Fe3+ chelating agent for crosslinking and ultrasonically mixing well to form gel. The implant has various functions of adhesion, hemostasis, bacteria resisting, inflammation diminishing and thermal chemotherapy of the wound, and postoperative relapse prevention of tumor can be realized by coating an irregular wound of the tumor with the implant and performing mild thermal chemotherapy.

The invention discloses a preparation method for a flame retardant super-hydrophobic melamine sponge. The method comprises the steps that firstly silicon dioxide particles are put into a trismetyl aminomethane buffer solution with a pH value of 7.8, ultrasound treatment is carried out for 20-60 minutes, standing is carried out for 15 minutes at the indoor temperature, and then a gallotannic acid solution and a silver nitrate solution are added in sequence to obtain a mixed solution; a melamine sponge is immersed in the mixed solution, taken out after the mixed solution is stirred for 2 hours at the indoor temperature, and washed by deionized water and ethyl alcohol for several times to obtain a melamine sponge of which the surface has a micro-nano structure; finally, the melamine sponge isput into an ethyl alcohol solution which has volume concentration of 1:500-10000 and contains 1H, 1H, 2H, 2H-perfluorododecane mercaptan, stirring is carried out for 12 hours at the indoor temperature, the melamine sponge is taken out, washed by ethyl alcohol for several times and dried to obtain the super-hydrophobic melamine sponge of which water contact angle is larger than or equal to 145 degrees. The preparation method for the flame retardant super-hydrophobic melamine sponge has the advantages that the preparation process is simple and convenient, the conditions are mild, and the adjustment and control of hydrophobic performance of the super-hydrophobic melamine sponge can be achieved by changing the concentration of a 1H, 1H, 2H, 2H-perfluorododecane mercaptan solution during the preparation.

The invention relates to the technical field of biological medicine, in particular to a vaccine vector and a preparation method and application thereof. The vaccine vector consists of oxidized mannan and a cationic polymer, the cationic polymer comprises at least one of polyethyleneimine, polyamide and poly beta urethane, or derivatives of the cationic polymer, or a block copolymer or graft copolymer of the cationic polymer and the derivatives thereof and polylactic acid or polylactic acid-glycolic acid. The vaccine vector disclosed by the invention is large in antigen loading capacity, simple and mild in vaccine preparation condition and good in stability, has excellent lymph node targeting and dendritic cell targeting capabilities, and can cause strong antigen-specific immune response.

The invention discloses a preparation method of super-hydrophobic sponge for adsorbing an organic solvent. The preparation method comprises the steps: placing silica particles into a trihydroxymethylaminomethane buffer solution with the pH value of 7.8, and carrying out ultrasonic treatment and standing; then, sequentially adding a tannic acid solution and a silver nitrate solution into the solution; soaking polyurethane sponge into the mixed solution, carrying out stirring at room temperature for 2 h, taking out the polyurethane sponge, cleaning the polyurethane sponge several times by usingdeionized water, and then, cleaning the polyurethane sponge several times by using ethanol to obtain polyurethane sponge of which the surface has a micronano structure; and placing the treated polyurethane sponge into an ethanol solution having the volume concentration of 1:1000 and containing 1H,1H,2H,2H-perfluorododecanethiol, carrying out stirring at room temperature for 12 h, taking out the polyurethane sponge, cleaning the polyurethane sponge several times by using ethanol, and drying the polyurethane sponge to finally obtain super-hydrophobic polyurethane sponge of which the water contact angle is larger than or equal to 150 DEG. The preparation method is simple and convenient in preparation process and mild in conditions, and the regulation of hydrophobic property of the super-hydrophobic sponge can be realized by changing the concentration of a silica solution in a preparation process.

The invention belongs to the technical field of biological nanomaterials, and discloses a preparation method of protamine (PS) modified PLGA coated icariin (LCA) nanospheres. The protamine modified PLGA coated icariin nanospheres (LCA at PLGA at PS) are prepared from the following raw materials according to specified parts: a dichloromethane solution of PLGA used as an oil phase; an icariin ethanol solution used as a medicine solution; a PVA aqueous solution used as an external water phase; and a protamine aqueous solution cation modified solution. The icariin ethanol solution and the PLGA dichloromethane solution are mixed to serve as the oil phase for the first time, the PVA aqueous solution serves as the water phase to react to generate PLGA coated icariin nanospheres, finally the surfaces of the nanospheres are modified with protamine for promoting cell absorptionto obtain the protamine-modified PLGA-coated icariin nanospheres, and the prepared nanospheres are uniform in size, safe and non-toxic. The invention aims to provide the preparation method of the nanospheres for improving the biological activity of icariin.