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Therapy diagnosis preparation based on polypyrrole compound and preparation method of preparation

The technology of polypyrrole and compound is applied in the field of preparation of therapeutic and diagnostic preparations, which can solve problems such as single use of diagnosis or treatment, and achieve the effects of simple preparation conditions, favorable clinical application, and mild preparation conditions.

Active Publication Date: 2014-10-29
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to obtain a diagnosis-treatment combined preparation with the functions of contrast-enhanced ultrasound diagnosis and photothermal therapy at the same time, to solve the various inconveniences caused by single use of diagnosis or treatment in traditional clinical practice, and to realize the same time with a composite preparation. Both diagnostic and therapeutic functions

Method used

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  • Therapy diagnosis preparation based on polypyrrole compound and preparation method of preparation
  • Therapy diagnosis preparation based on polypyrrole compound and preparation method of preparation
  • Therapy diagnosis preparation based on polypyrrole compound and preparation method of preparation

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0027] (1) Weigh 6.6684g of sodium bis(2-ethylhexyl)sulfosuccinate (NaDEHS) into 90mL of deionized water, place in an ice-water bath and stir to dissolve. After it was completely dissolved, 2.769 mL of pyrrole monomer was added to the system, and after continuous stirring for 5 min, 2.282 g of ammonium persulfate solution was added thereto, and the whole system was reacted in an ice-water bath for 20 h. After the reaction, centrifugation to obtain the soluble polypyrrole complex [(Py) 3 + (DEHS) - ] x .

[0028] (2) Weigh 100 mg soluble polypyrrole complex [(Py) 3 + (DEHS) - ] x Dissolve 80μL of liquid fluorocarbon in 4mL of dichloromethane, add it to pre-cooled 2% polyvinylpyrrolidone solution after complete dissolution, homogenize at 9500rpm for 2min with a high-speed dispersing homogenizer, and then magnetically stir for 2h to make the dichloromethane After volatilization, centrifuge at 5000 g for 5 minutes, collect the precipitate and wash it with water under the s...

specific Embodiment approach 2

[0029] (1) Weigh 6.6684g of sodium bis(2-ethylhexyl)sulfosuccinate (NaDEHS) into 90mL of deionized water, place in an ice-water bath and stir to dissolve. After it was completely dissolved, 2.769 mL of pyrrole monomer was added to the system, and after continuous stirring for 5 min, 2.282 g of ammonium persulfate solution was added thereto, and the whole system was reacted in an ice-water bath for 20 h. After the reaction, centrifugation to obtain the soluble polypyrrole complex [(Py) 3 + (DEHS) - ] x .

[0030] (2) Weigh 100 mg soluble polypyrrole complex [(Py) 3 + (DEHS) - ] x Dissolve 60 μL of liquid fluorocarbon in 4 mL of dichloromethane, add it to pre-cooled 2% polyvinylpyrrolidone solution after complete dissolution, sonicate with a probe-type ultrasonic instrument for 2 minutes, and then magnetically stir for 2 hours to volatilize the dichloromethane, Centrifuge at 8000rpm for 5min, collect the precipitate and wash it with water under the same centrifugation co...

specific Embodiment approach 3

[0031] (1) Weigh 6.6684g of sodium bis(2-ethylhexyl)sulfosuccinate (NaDEHS) into 90mL of deionized water, place in an ice-water bath and stir to dissolve. After it was completely dissolved, 2.769 mL of pyrrole monomer was added to the system, and after continuous stirring for 5 min, 2.282 g of ammonium persulfate solution was added thereto, and the whole system was reacted in an ice-water bath for 20 h. After the reaction, centrifugation to obtain the soluble polypyrrole complex [(Py) 3 + (DEHS) - ] x .

[0032] (2) Weigh 100 mg soluble polypyrrole complex [(Py) 3 + (DEHS) - ] x Dissolve in 4mL of dichloromethane, add to pre-cooled 2% polyvinylpyrrolidone solution after complete dissolution, homogenize at 9500rpm for 2min with a high-speed dispersing homogenizer, then magnetically stir for 2h to volatilize the dichloromethane, then centrifuge at 5000g After 5 minutes, the precipitate was collected and washed with water under the same centrifugation conditions to obtain...

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Abstract

The invention relates to a therapy diagnosis preparation based on a polypyrrole compound and a preparation method of the preparation. The prepared polypyrrole preparation possesses both ultrasound contrast diagnosis function and photo-thermal therapy function, successively combines real time, high efficiency, low cost, no radiation and other characteristics of ultrasound contrast diagnosis and high selectivity and high curative effect of near-infrared photo-thermal therapy , helps to substantially increase the diagnosis-therapy efficiency, and has extremely good clinical application potential.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and relates to a preparation method of a polypyrrole complex-based therapeutic diagnosis preparation. Background technique [0002] Photothermal therapy is a minimally invasive treatment technology developed in recent years. It mainly kills diseased cells by directly irradiating light energy to the lesion to increase the local temperature, thereby greatly reducing systemic toxicity. In order to improve the efficiency and selectivity of laser-induced photothermal therapy, photothermal therapeutic agents with light-absorbing properties are usually introduced into the lesion. Since near-infrared light has the best penetrability to tissues, an ideal photothermal therapeutic agent should have strong absorption in the near-infrared light region (650-950nm), low toxicity, and functional groups can be attached to the surface to achieve active targeting. treat. In addition, successful photo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K47/32A61K41/00A61K9/51A61P35/00A61P17/10A61P29/00
Inventor 戴志飞查正宝王金锐曲恩泽
Owner PEKING UNIV
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