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Method for preparing chitosan polyvinyl alcohol gel rubber containing nano granule of hydroxyapatite

A technology of hydroxyapatite and polyvinyl alcohol, which is applied in the field of biomedical composite materials, can solve the problems of weak gel strength, sudden release of drugs, slow release time of drugs, etc., and achieves simple and mild preparation conditions, avoiding organic chemical reagents and Other harmful substances, the effect of meeting environmental protection requirements

Active Publication Date: 2010-04-14
HUASHAN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan and polyvinyl alcohol can form an injectable temperature-sensitive gel, which can be used for drug sustained release and tissue engineering, but the disadvantages are weak gel strength, drug burst release phenomenon and long drug sustained release time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: 200mg chitosan is dissolved in the hydrochloric acid solution that concentration is 0.1mol / l, is mixed with 2wt% solution; 100mg particle diameter is positioned at the hydroxyapatite nano-particle between 100~500nm and is directly dispersed in 1ml After distilled water, add it to the chitosan solution, and stir in an ice bath for 15 minutes; dissolve 200 mg of polyvinyl alcohol and prepare a 2wt% solution; add 84 mg of sodium bicarbonate to the polyvinyl alcohol solution, and place it in an ice bath for 15 minutes ; Then under constant stirring and under an ice bath, slowly drop the polyvinyl alcohol solution into the chitosan hydrochloric acid solution, stir for 10 minutes, and the pH value of the mixed solution is 6.7. Finally, the solution was placed at a gel temperature of 37° C. for 30 minutes to obtain a gel, and its strength was measured to be 160 Pa by a dynamic rheometer. The mass ratio of chitosan and polyvinyl alcohol in the gel is 1:1. Taking ...

Embodiment 2

[0028] Embodiment 2: 200mg chitosan is dissolved in the hydrochloric acid solution that concentration is 0.1mol / l, is mixed with 2wt% solution; 28mgCaCl 2 Dissolve in chitosan solution, stir in ice bath for 15min; dissolve 100mg polyvinyl alcohol, prepare 1wt% solution; mix 84mg NaHCO 3 and 57mgNa 3 PO 4 12H 2 O (or the corresponding amount of anhydrous Na 3 PO 4 ) into the polyvinyl alcohol solution, and also placed in an ice bath for 15 minutes; then slowly drip the polyvinyl alcohol solution into the chitosan hydrochloric acid solution under constant stirring and ice bath, stir for 10 minutes, and the pH of the mixed solution is 6.8. Finally, the solution was placed at a gel temperature of 37° C. for 30 minutes to obtain a gel, and its strength was measured to be 530 Pa by a dynamic rheometer. The mass ratio of chitosan and polyvinyl alcohol in the gel is 2:1. Taking chitosan as a reference, the mass ratio of hydroxyapatite nanoparticles to chitosan in the gel is 1:4...

Embodiment 3

[0029] Embodiment 3: 400mg chitosan is dissolved in hydrochloric acid solution, is mixed with 4wt% solution; 56mgCaCl 2 Dissolve in chitosan solution, stir in ice bath for 15min; dissolve 100mg polyvinyl alcohol, prepare 1wt% solution; mix 168mgNaHCO 3 and 114mgNa 3 PO 4 12H 2O was added to the polyvinyl alcohol solution, and also placed in the ice bath for 15 minutes; then under constant stirring, the polyvinyl alcohol solution was slowly dropped into the chitosan hydrochloric acid solution under the ice bath, stirred for 10 minutes, and the pH of the mixed solution was 7.0. Finally, the solution was placed at a gel temperature of 37° C. for 30 minutes to obtain a gel, and its strength was measured to be 590 Pa by a dynamic rheometer. The mass ratio of chitosan and polyvinyl alcohol in the gel is 4:1. Taking chitosan as a reference, the mass ratio of hydroxyapatite nanoparticles to chitosan in the gel is 1:4.

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Abstract

The invention discloses a chitose / polyvinyl alcohol composite gel with hydroxyapatite nanometer particle and making method and application, which comprises the following parts: hydroxyapatite nanometer particle, chitose and polyvinyl alcohol, wherein the weight of chitose and polyvinyl alcohol is between 1: 20 and 8: 1 and the weight of hydroxyapatite nanometer particle and chitose is between 0. 5: 1 and 2: 1. The invention provides two making method of the composite gel, including directly adding method and original position generating method. The composite gel can be drug carrier to releasesensitive drug slowly and injecting medical material to repair articular cartilage and organize engineering rack material, which can be applied in the cell culture.

Description

technical field [0001] The invention relates to a preparation method of chitosan / polyvinyl alcohol gel containing hydroxyapatite nanoparticles, belonging to the field of biomedical composite materials. Background technique [0002] Hydrogels have been widely used in drug release and tissue engineering due to their good biocompatibility, swelling property and inactivation of drug loading. According to different connection methods, hydrogels can be divided into chemical gels and physical gels. Chemical gel is formed by chemical reaction to form covalent bonds under the action of chemical cross-linking agent or initiator, and the remaining chemical cross-linking agent or initiator after it is formed has certain toxicity. Physical gels interact through non-covalent bonds and avoid the use of chemical solvents, so they are favored. [0003] In recent years, the in situ gel system has received extensive attention because it can be applied to biological applications such as drug ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L31/10A61K47/36
Inventor 杜予民汤玉峰李艳
Owner HUASHAN TECH CO LTD
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