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Charge reversal-mediated injectable colloid grain drug gel slow-release implant and preparation method thereof

A slow-release implant and charge reversal technology, which can be used in pharmaceutical formulations, drug combinations, drug delivery, etc., can solve problems such as poor chemotherapy effect, single photothermal, and inability to diagnose, so as to save time and stabilize photothermal performance , the effect of increasing efficiency

Inactive Publication Date: 2019-03-19
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a charge-reversal-mediated injectable colloid drug gel sustained-release implant and its preparation method, thereby solving the problems caused by the inability to diagnose and the poor effect of single photothermal or chemotherapy in traditional clinical practice. Inconveniences, using a compound preparation to achieve both functions of diagnosis and treatment at the same time, while solving the problem of poor efficacy of traditional single treatment

Method used

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  • Charge reversal-mediated injectable colloid grain drug gel slow-release implant and preparation method thereof
  • Charge reversal-mediated injectable colloid grain drug gel slow-release implant and preparation method thereof
  • Charge reversal-mediated injectable colloid grain drug gel slow-release implant and preparation method thereof

Examples

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Effect test

Embodiment 1

[0045] Example 1: Preparation of a charge-reversal-mediated injectable colloid drug gel sustained-release implant

[0046] Prepare a suspension of gelatin nanoparticles and polydopamine nanoparticles with a pH of 12 and a concentration of 100 mg / mL, and mix the polydopamine nanoparticle suspension and the gelatin nanoparticle suspension at a volume ratio of 1:4. Then add the ground D-glucono-δ-lactone to it so that the concentration is 50 mg / mL, acidify and flocculate at room temperature for 1 hour, at this time the pH drops to 6-7, and a charge-reversal mediated Injectable colloid drug gel sustained-release implants.

[0047] The injectability and self-healing performance of the injectable colloid drug gel sustained-release implant (1mL) were evaluated using a TA Discovery DHR-3 rotational rheometer: the test temperature was 25°C, and the test gap was 1000 μm. The 1mL sample was tested under 1% pressure for 5 minutes in time-scanning mode, then tested under 1000% pressure fo...

Embodiment 2

[0049] Example 2: Preparation of a charge-reversal-mediated injectable colloid drug gel sustained-release implant loaded with doxorubicin to prepare gelatin nanoparticles and polydopamine nanoparticles with a pH of 12 and a concentration of 100 mg / mL suspension of particles. Add 120 μg doxorubicin to 200 μL polydopamine nanoparticle suspension and stir at room temperature for 30 minutes. Then, according to the volume ratio of polydopamine nanoparticle suspension and gelatin nanoparticle suspension of 1:4, the two were mixed evenly. Add the ground D-glucono-δ-lactone to it to make the concentration 50mg / mL, acidify and flocculate for 1h at room temperature, at this time, the pH drops to 6-7, and a kind of doxorubicin is obtained. Charge-reversal-mediated injectable colloidal drug gel sustained-release implants.

[0050] Utilize the MDL-III-808-2 laser and the Fluke TI400IR thermal imager to carry out the photothermal performance evaluation on the injectable colloid drug gel s...

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Abstract

The invention discloses a charge reversal-mediated injectable colloid grain drug gel slow-release implant and a preparation method thereof. The implant contains the following components: polydopaminenanoparticles, gelatin nanoparticles, an acid former and a drug. The preparation method comprises the steps of respectively dispersing the polydopamine nanoparticles and the gelatin nanoparticles intoan alkaline solution, adding an anti-cancer drug before use, acidizing by virtue of the acid former, uniformly mixing until the mixture is acidized into gel, and carrying out intratumor injection. The implant prepared by virtue of the preparation method can be simultaneously taken as a photo-thermal treatment agent and a drug carrier, the nuclear magnetism imaging diagnosis can be realized through T2 weighting under relatively low laser intensity and relatively chemotherapy drug dosage, and the release of acid / thermal / enzyme responsive drug and the synergetic treatment of the photo-thermal treatment are realized, so that the integration of the diagnosis and treatment of cancers is realized.

Description

technical field [0001] The invention belongs to the field of nanomaterial preparation and biomedicine, and relates to an injectable colloid drug gel slow-release implant mediated by charge reversal and a preparation method thereof Background technique [0002] Cancer seriously damages people's health and hinders the development of society. It has become a public health problem that cannot be ignored in our country and even in the world. Conventional methods clinically used to treat tumors include surgical therapy, radiation therapy, and chemotherapy. Although these therapies can effectively kill tumor tissue to a certain extent, each therapy has many disadvantages and limitations. The method of photothermal therapy is to inject photothermal reagents with high photothermal conversion efficiency into the body. These photothermal reagents are enriched around the tumor tissue through targeted recognition technology. Under the irradiation of external light source, it can absorb ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/06A61K47/62A61K47/59A61K41/00A61K49/14A61K49/12A61K49/18A61P35/00A61P17/10A61P29/00
CPCA61K9/0024A61K9/06A61K41/0052A61K49/12A61K49/14A61K49/1806A61K47/59A61K47/62A61P17/10A61P29/00A61P35/00
Inventor 查正宝贺港陈胜陆杨马艳缪昭华
Owner HEFEI UNIV OF TECH
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