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High-precision amplifying circuit especially for ion sensitive field effect sensor

A technology of ion-sensitive field effect and amplifier circuit, which is applied in the field of biosensors, can solve problems that are difficult to realize, and achieve the effects of suppressing temperature drift, novel structure, and high power supply rejection ratio

Active Publication Date: 2010-05-12
INST OF ELECTRONICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the field of modern biomedicine, trace detection is usually required, that is, the detection of weakly changing biomass signals, which is difficult to achieve using the above-mentioned traditional methods

Method used

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  • High-precision amplifying circuit especially for ion sensitive field effect sensor
  • High-precision amplifying circuit especially for ion sensitive field effect sensor
  • High-precision amplifying circuit especially for ion sensitive field effect sensor

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Embodiment Construction

[0045] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be described in further detail below in conjunction with specific embodiments and with reference to the accompanying drawings.

[0046] Such as figure 1 as shown, figure 1 The circuit diagram of the high-precision amplifier dedicated to the ion-sensitive field effect sensor provided by the present invention, the high-precision amplifier circuit at least includes a main amplifier 11, an auxiliary amplifier 12 and a clock 14.

[0047] Among them, the main amplifier 11 is used to continuously amplify the sensitive signal input by the sensitive gate of the sensor, and output the final amplification processing result.

[0048] The auxiliary amplifier 12 is used to alternately receive the sensitive signal input by the sensitive gate of the sensor under the control of the clock, amplify the received sensitive signal to obtain the amplified processing res...

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Abstract

The invention discloses a special high-precision amplifier circuit used for ion sensing effect sensor. It includes the main amplifier to amplify the sensing signal input by the sensing bar continuously and output the result; the assistant amplifier to receive the sensing signal input by the sensing bar controlled by the timer and amplify the sensing signal to get the result, also it is connected with the input of the main amplifier controlled by the timer and output the result to the main amplifier; the timer is to control the connect between the assistant amplifier and the sensing bar to makethe assistant amplifier receive the sensing signal input by the sensing bar and control the connect between the assistant amplifier and the main amplifier to output the assistant amplifier result tothe main amplifier. The invention can improve the measuring precision and inhibit the temperature float to reach the trace detection.

Description

technical field [0001] The invention relates to the technical field of biosensors, in particular to a high-precision amplifier circuit dedicated to an ion-sensitive field effect sensor for trace detection. Background technique [0002] The ion sensitive field effect transistor (Ion Sensitive Field Effect Transistor, ISFET) belongs to the semiconductor biosensor, which was invented by P. Bergveld in the early 1970s. [0003] The ISFET is in direct contact with the ions in the solution to be measured and the buffer solution through different sensitive film materials on the gate, so that the ion concentration in the solution can be measured. [0004] ISFET has the dual characteristics of both electrochemical and MOSFET. Compared with the traditional ion selective electrode (ISE), ISFET has the advantages of small size, sensitivity, fast response, no label, convenient detection, easy integration and mass production. Therefore, ISFET has broad application prospects in life scien...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/414
Inventor 杨海钢魏金宝
Owner INST OF ELECTRONICS CHINESE ACAD OF SCI
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