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Astragalus root fermentation liquor and uses thereof

A technology of fermented liquid and astragalus, applied in the field of fermentation of traditional Chinese medicine astragalus, to achieve the effects of reducing environmental hazards, improving curative effect, and enhancing drug efficacy

Active Publication Date: 2008-03-12
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In the existing literature, it has not been found that large edible fungi are used as the starting strain of traditional Chinese medicine fermentation, and traditional Chinese medicinal materials are used as the main material of the fermentation medium, and the cellulase, hemicellulase, pectinase, amylase, etc. , decompose lignocellulose, hemicellulose, lignin, pectin and other substances in Chinese medicinal materials, and fully release the active components of Chinese medicinal materials in the fermented aqueous solution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Preparation of astragalus fermented liquid.

[0027] The fermentation strain used in the present invention is large edible fungus Pleurotus ostreatus. Composition of fermentation medium (unit: g / L): astragalus 30-90, bran 10-20, gypsum 0.5-1.5, distilled water. Astragalus is crushed to a 60-mesh powder; the bran juice is filtered to obtain a filtrate; gypsum is crushed to a 60-mesh powder. 500mL Erlenmeyer flasks were divided into 120-170mL of culture medium, and after autoclaving, inoculated with liquid fermentation strains, the inoculum amount was 5-15%, and cultured on a shaking table under the conditions of 25-28°C and 130-180r / min, and the culture time was 6-10 days to obtain the astragalus fermented liquid. The astragalus fermented liquid is centrifuged at 3500-5000 r / min to obtain a supernatant, which can be directly used as food, health products and medicines, or used as raw materials for preparing food, health products and medicines.

Embodiment 2

[0028]Example 2: Anti-hypoxic activity of astragalus fermentation supernatant.

[0029] Experimental animals: healthy male Kunming mice, weighing 20±2g.

[0030] Experimental drug: The supernatant prepared according to Example 1 was formulated into three concentration dosages of large, medium and small, and the original crude drug contents were 0.412g / mL, 0.206g / mL and 0.052g / mL respectively. The original crude drug content in the supernatant of the control group without inoculation was 0.206g / mL. The original crude drug content in the supernatant of the water decoction control group was 0.206g / mL.

[0031] Animal experiment:

[0032] ①. Acute cerebral ischemic hypoxia experiment:

[0033] 60 mice were randomly divided into 6 groups, 10 in each group, divided into 3 doses of large, medium and small doses of astragalus fermented group, astragalus non-inoculated control group, astragalus water decoction group and blank control group, blank control group was given sterile wat...

Embodiment 3

[0043] Example 3: Anticoagulant activity of astragalus fermentation supernatant:

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PUM

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Abstract

The invention relates to the art of Chinese medicine processing and bio-fermentation, in particular to a fermentation method of Chinese milkvetch and an application of fermented product through the method. The invention makes the fermentation of Chinese milkvetch by taking large edible fungus as the starting fungus of Chinese medicine fermentation, Chinese milkvetch as the main material of fermentation culture medium and adding a small amount of necessary nutrients for fungus production and growth. Animal experiment show that the fermented milkvetch liquid has the anti-anoxia and anticoagulant effect. The application of the invention refers to the fermented milkvetch liquid obtained through the method can be applied in preparing anti-anoxia and anticoagulant medicine as well as corresponding health products and food.

Description

Technical field: [0001] The invention relates to the fields of traditional Chinese medicine processing and biological fermentation, in particular to a fermentation method of the traditional Chinese medicine astragali and the application of the fermentation product obtained by the method. Background technique: [0002] Astragalus, the root of Astragalus membrane pod Astragalus membranaceus (Fisch.) Bge. and A. membranaceus Bge.varmongholicus (Bge.) Hsiao of Inner Mongolia, produced in Northeast, Northwest, North China and other places [1] . Astragalus is listed as the top grade by "Shen Nong's Materia Medica", and it is one of the commonly used medicines. It is an important Qi-invigorating medicine. [2] . Pharmacological experiments have proved that Astragalus has antibacterial effects, enhances the body's immunity, expands peripheral blood vessels, improves peripheral circulation, and improves local nutritional status. [1] . In addition, Astragalus still has hypoxia resi...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P7/02A61P39/00A23L1/30A61K125/00A23L33/10
Inventor 李红玉王士中
Owner LANZHOU UNIVERSITY
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