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A medicine for treating chronic renal failure and its preparing method

A kidney function and drug technology, which is applied in the field of drugs for the treatment of chronic renal failure, can solve the problems of decoction and inconvenient carrying, and achieve the effect of increasing urine output

Active Publication Date: 2012-05-30
江西省药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the disadvantages of decoction and inconvenient carrying of the traditional Chinese medicine decoction for the treatment of chronic renal failure, and provide a safe, effective, quality-controllable, and easy-to-carry Chinese patent medicine preparation for the majority of patients with chronic renal failure

Method used

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  • A medicine for treating chronic renal failure and its preparing method
  • A medicine for treating chronic renal failure and its preparing method
  • A medicine for treating chronic renal failure and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Weigh raw materials according to the following ratio:

[0059] 30 parts of Astragalus, 15 parts of Poria cocos, 30 parts of Hedyotis diffusa, 20 parts of Liuyuexue, 20 parts of Lubiancao

[0060] 10 parts of Chuanxiong, 15 parts of Morinda officinalis, 30 parts of Centella asiatica, 20 parts of rhubarb

[0061] (1) Take astragalus, rhubarb, Hedyotis diffusa, Centella asiatica, and Ligusticum chuanxiong and grind them into coarse powder, then reflux extract with 60% ethanol 8 times the amount of the total medicinal materials for 4 times, each time for 2 hours, collect the extract, and set aside .

[0062] (2) Take Luniancao, Morinda officinalis, Fa Pinellia, and Coptis chinensis, add water and decoct twice, 3 hours each time, combine the decoction, filter, concentrate, let it cool, add ethanol to make the ethanol content reach 70% , placed for 48 hours, and the supernatant was taken for later use.

[0063] (3) Combine the supernatant obtained in (2) with the extract o...

Embodiment 2

[0066] Weigh raw materials according to the following ratio:

[0067] 40 parts of Astragalus, 12 parts of Poria cocos, 25 parts of Hedyotis diffusa, 25 parts of Liuyuexue, 15 parts of Lushicao

[0068] 8 parts of Chuanxiong, 12 parts of Morinda officinalis, 40 parts of Centella asiatica, 15 parts of rhubarb

[0069] (1) Take astragalus, rhubarb, Hedyotis diffusa, Centella asiatica, and Ligusticum chuanxiong and grind them into coarse powder, then reflux extract with 60% ethanol 6 times the amount of the total medicinal materials for 3 times, each time for 3 hours, collect the extract, and set aside .

[0070] (2) Take Luniancao, Morinda officinalis, Pinellia, and Coptis chinensis, add water and decoct twice, 3 hours each time, combine the decoction, filter, concentrate, let it cool, add ethanol to make the ethanol content reach 60% , placed for 24 hours, and the supernatant was taken for later use.

[0071] (3) Combine the supernatant obtained in (2) with the extract obtain...

Embodiment 3

[0074] Weigh raw materials according to the following ratio:

[0075] 45 parts of Astragalus, 14 parts of Poria cocos, 35 parts of Hedyotis diffusa, 18 parts of Liuyuexue, and 25 parts of Lubiancao

[0076] 12 parts of Chuanxiong, 8 parts of Morinda officinalis, 20 parts of Centella asiatica, 10 parts of rhubarb

[0077] (1) Take astragalus, rhubarb, Hedyotis diffusa, Centella asiatica, and Ligusticum chuanxiong and grind them into coarse powder, then reflux extract with 60% ethanol 10 times the amount of the total medicinal materials for 2 times, each time for 4 hours, collect the extract, and set aside .

[0078] (2) Take Luancao, Morinda officinalis, Pinellia, and Coptis chinensis, add water and decoct 3 times, 2 hours each time, combine the decoction, filter, concentrate to a relative density of 1.14-1.20 (60-65°C), Let it cool down, add ethanol to make the ethanol content reach 55%, and let it stand for 48 hours. Take the supernatant for later use.

[0079] (3) Combin...

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Abstract

The present invention relates to a medicine for treating chronic renal failure. The chronic renal failure is the final result of various kidney diseases, but without effective western medicine in clinic yet, and dialysis therapy and renal transplantation price are expensive and not suitable for early and middle patients. The medicine whole formula of the present invention both activates and tonifies, consideration to right and evil, nourishing and releasing integrated, leading nourishing not stagnating evil, releasing not injuring right, can not only delay chronic renal failure course, but also improve or eliminate clinical symptoms, having good curative effect, lower cost characteristic. The present invention concretely is with radix astragali, poria, hedyotis diffusa, serissa foetida, pyrola calliantha, ligusticum chuanxiong, morinda officinalis how, centella asiatica, prepared rhubarb and etc. traditional Chinese medicine to prepare into compound preparation. The present invention also relates to the medicine preparation method. As pharmacological experiment shows the present invention can obviously decrease adenine causing chronic renal failure rat and nephrectomy causing chronic renal failure rat kidney function Crea and BUN value, the present invention can also obviously increase water load rat urinary volume.

Description

technical field [0001] The invention relates to a medicine for treating chronic renal failure, in particular to a traditional Chinese medicine compound preparation made from traditional Chinese medicines such as Astragalus, Poria cocos, Hedyotis diffusa and the like, and also relates to a preparation method of the medicine. Background technique [0002] Chronic renal failure refers to the damage of renal structure and function caused by primary or secondary renal diseases, and causes a series of metabolic disorders and clinical symptoms. It is the final result of various renal diseases. At present, the Western medicine treatment of chronic renal failure mainly relies on dialysis therapy and kidney transplantation, or through some treatment principles for chronic renal failure, such as restricting protein intake, correcting water and electrolyte disorders and acid-base balance disorders, controlling infection and symptomatic treatment . So far, there is still no effective we...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61K9/00A61P13/12
Inventor 肖小华曾文丽赵纪生朱令元徐丽瑛刘良玉
Owner 江西省药物研究所
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