Medicine for treating uaemia and insufficiency of kidney-yang and kidney exhaustion and its preparing method

A technology for kidney yang deficiency and renal failure, which is applied in the field of medicine and its preparation for the treatment of uremia, kidney yang deficiency and renal failure, which can solve the problems of high cost and achieve the effects of reducing blood viscosity, quick effect and short course of treatment

Active Publication Date: 2005-10-19
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] According to reports, the incidence rate of chronic renal failure, kidney yang deficiency and uremia in my country is 1.5% of the total population, that is, there are about 195,000 patients with this disease every year, and there are about 800,000 people in the world every year. The main treatment method of Western medicine, there is no exclusive drug in the middle and early stage, it is only symptomatic treatment, and it treats the symptoms. In the middle and late stage, it can only be an alternative treatment. The method is peritoneal and hemodialysis maintenance, and finally can only use kidney transplantation , the cost is very high, especially for developing countries, where many patients are beyond their means

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0036] Study on the main pharmacodynamics of Shuangshenling Granules

[0037] Abstract: Oral administration of Shuangshenling Granules can significantly reduce the increase of serum urea nitrogen (Bun) and serum creatinine (Crea) in rats with chronic renal failure induced by freezing, and significantly increase the hemoglobin in the state of chronic renal failure induced by freezing. It can significantly reduce the increase of serum Bun and Crea in rats with chronic renal failure caused by adenine, indicating that Shuangshenling Granules can significantly improve hypernitremia and anemia in rats with chronic renal failure. Preventive administration has obvious inhibitory effect on the increase of Bun and Crea in rats with chronic renal failure caused by adenine, and has obvious inhibitory effect on the weight loss and kidney enlargement caused by adenine, which shows that Shuangshenling Granules preventive administration Drugs can improve the state of the...

experiment example 2

[0083] Study on Long-term Toxicity of Shuangshenling Granules in Rats

[0084] Abstract: Shuangshenling granule 12.50g / kg, 6.25g / kg, 3.13g / kg was administered orally continuously for six months (50 times, 25 times, 12.5 times the human dose), from appearance behavior, food intake and drinking water, body weight, blood No obvious toxic reaction was found in the multi-indicator detection of medicine, blood biochemistry, pathology and so on. After stopping the drug for 2 weeks, the indicators were repeatedly tested, and no delayed toxic reaction was found in the drug.

[0085] Purpose of the test: To observe the toxic reaction and its severity of continuous gavage administration to rats for six months. Provide the target organ of toxic reaction and the reversibility of its damage, determine the dose of non-toxic reaction, and provide a safe dose for clinical medication.

[0086] Test drug: Shuangshenling Granules, each gram of powder contains about 3.27g of crude ...

Embodiment 1

[0107] 《Example 1》The composition of the raw materials of the medicine of the present invention and the method for preparing it into tablets

[0108] Medicine of the present invention is made up of following raw material by weight ratio:

[0109] Astragalus: Chuanxiong: Salvia: Rhubarb = 450:225:300:225.

[0110] The method that it is prepared into tablet comprises the following steps:

[0111] (1), add 9 times the water of Rhizoma Chuanxiong in said weight ratio to extract the volatile oil, the volatile oil is clathrated with γ-cyclodextrin, the ratio of volatile oil and γ-cyclodextrin is 1:9, the stirring time is 30min, the temperature At 35°C, the clathrate of volatile oil was obtained and set aside;

[0112] (2), mix the astragalus root and rhubarb of said weight ratio, add 10 times the amount of 85% ethanol to reflux twice, each time for 1 hour, filter, the two filtrates are combined, reclaim ethanol, and concentrate to a relative density of 1.30 (55~ 60°C) clear ointm...

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Abstract

The medicine for treating uaemia and kidney-Yang deficiency and kidney exhaustion is prepared with astragalus root, Chuanxiong rhizome, red sage and rhubarb in certain proportion. The medicine has the functions of warming and invigorating spleen and kidney, promoting blood circulation to disperse blood clots, and eliminating wetness and expelling turbid substance, so that it has high curative effect and no toxic side effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for treating uremia and kidney disease, in particular to a medicine for treating uremia, kidney-yang deficiency and kidney failure and a preparation method thereof. Background technique [0002] According to reports, the incidence rate of chronic renal failure, kidney yang deficiency and uremia in my country is 1.5% of the total population, that is, there are about 195,000 patients with this disease every year, and there are about 800,000 people in the world every year. The main treatment method of western medicine has no exclusive drugs in the middle and early stages, and it is only symptomatic treatment, which treats the symptoms. In the middle and late stages, it can only be an alternative treatment. The method is peritoneal and hemodialysis maintenance, and finally only kidney transplantation. , the cost is very high, especially for developing countries, many patients can't afford it. Finding a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P13/12
Inventor 张明国
Owner XIAN SHIJISHENGKANG PHARMA IND
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