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Medicine for treating male erectile dysfunction

A technology for erectile dysfunction and drugs, applied in drug combination, drug delivery, sexual diseases, etc., can solve the problems of limited wide application, high price, blood pressure drop, etc., to enhance immune function, low price, and improve cardiovascular elasticity. Effect

Inactive Publication Date: 2008-04-30
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, sildenafil has the most ideal curative effect, with a total effective rate of 70%, but this drug can produce side effects such as blurred vision, headache, blush, and blood pressure drop, and is expensive, which limits its wide application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Through long-term oral administration of sildenafil citrate (Viagra) and the medicine provided by the present invention, the comparison of the curative effect on enhancing penile erectile function.

[0012] After feeding male SD rats with 2.25g / kg·d, 4.5g / kg·d L-arginine and 45mg / kg·d group of sildenafil citrate for eight weeks, the results showed that the above groups Both can improve the erectile function of rats, the intracavernous pressure of rats induced by electrical stimulation is significantly higher than that of the untreated group, the nitric oxide content and nitric oxide synthase activity in serum and penis tissue are significantly increased, and the GSH content in serum is significantly improved. and SOD activity are also enhanced; taking L-arginine low-dose group (2.25g / kg·d) effect is better than high-dose group (4.5g / kg·d), and taking L-arginine low-dose group The effect is equivalent to that of the 45 mg / kg·d sildenafil citrate group, even slightly bett...

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Abstract

The invention discloses a medicament for the treatment of functional disturbance of men's erection, which is made up of L-arginine with the mass ratio of 30-95% and a solid agent or a liquid agent with the mass ratio of 5-70%. The medicament can be made into capsules, drinkable solution, pills, and tablets, dripping or spraying agent, suppository or patches. The medicament can be take by oral administration, or administered through tongue, nasal cavity, rectal intestine, or skin, and the medicament which contains L-arginine of 1-2.7 g, 2.9-4.9 g, or 5.1-10.0 g is taken everyday for 2- 8 weeks or more constantly or discontinuously. The medicament has the advantages of low price, good erecting effect, high safety, few side effects, and many aggregate effects, and the medicament also can improve the heart functions of patients who suffer form congestive heart failures, enhance immunologic function, and prevent oxidation, age and arteriosclerosis. The invention is safer than Viagra for patients who suffer ED and especially the patients who have had heart disease.

Description

technical field [0001] The invention relates to a medicine for treating male erectile dysfunction, which belongs to the field of pharmaceuticals Background technique [0002] Male erectile dysfunction is a worldwide medical problem. According to relevant statistics at home and abroad, there are more than 100 million men suffering from ED in various degrees around the world. A survey of 40-70-year-old men in Britain and France found that the prevalence of moderate to complete ED reached 40%. Domestic investigation of 2,226 adult males in Beijing, Chongqing, and Guangzhou showed that the overall prevalence of ED was 26.1%, while that of people aged 40 and above was 40.2%. Patients often feel pain because they cannot have a normal sex life, and the psychological pressure and social pressure are particularly high, which seriously affects the quality of life of patients. [0003] At present, there are oral drugs for the treatment of male erectile dysfunction, such as alpha-rece...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K9/02A61K9/08A61K9/12A61K9/20A61K9/70A61P15/10
Inventor 张杰彭建平杜贤进
Owner WUHAN UNIV
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