Colon targeting drug delivery soft capsule and preparation method thereof

Active Publication Date: 2008-04-30
惠州市九惠药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as an oily drug, although there are products filled with hard capsules, due to the limitations of technology and equipment, there are few products in China that are industrialized
Soft capsule

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 1 Experimental materials

[0060] 1.1 Drugs and reagents

[0061] Drugs: Vitamin AD small capsules from Guangzhou Zhujiang Pharmaceutical Factory

[0062]Brucea javanica oil soft capsules, loading capacity 0.53g, self-made, conventional technology.

[0063] Reagents: absolute ethanol produced by Tianjin Fuyu Fine Chemical Co., Ltd., acetone produced by Tianjin Fuyu Fine Chemical Co., Ltd., diethyl phthalate produced by Tianjin Damao Chemical Reagent Factory, Tianjin Damao Chemical Castor oil produced by Reagent Factory, ethyl cellulose produced by Beijing Jingqiu Chemical Co., Ltd., cellulose acetate (cellulose diacetate) produced by Sinopharm Chemical Reagent Co., Ltd., Tween produced by Tianjin Damao Chemical Reagent Factory -80, acrylic resin III and II produced by Lianyungang Wantai Pharmaceutical Materials Co., Ltd., and Eudragit S100 produced by Rohm, Germany.

[0064] 1.2 Instruments

[0065] The BY-400 water chestnut type sugar coating machine produced by Ta...

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PUM

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Abstract

The invention discloses a colonic targeting drug-delivery soft capsule, which comprises a brucea javanica oil soft capsule and high polymer coating film, wherein the high polymer coating film is pH-sensitive enteric coated cover which contains component of ethyl cellulose or acetyl cellulose. The invention provides accurate composition of high polymer coating film, realizes indisintegration of soft capsule after being coated in the buffer solution with pH value less than seven and disintegration in the buffer solution with pH value more than seven, and achieves requirements of ideal colon-specific drug delivery. The invention with simple process for preparation and mature process condition compensates the blank that no soft capsule for colon drug delivering is developed and applied.

Description

technical field [0001] The invention relates to a drug preparation for the digestive tract, especially a preparation suitable for localized and targeted colon drug administration and a preparation method thereof. Background technique [0002] Colon cancer and rectal cancer are common malignant tumors of digestive tract. The incidence of colorectal cancer can reach 20 per 100,000, and the annual death rate of colorectal cancer in most provinces and cities in China accounts for 5-6 of all malignant tumor mortality. [0003] Ulcerative colitis or chronic nonspecific ulcerative colitis is a kind of chronic colitis with unknown cause. It is a common and frequently-occurring disease. In severe cases, it often causes pseudopolyps and even cancer. 5-10 times higher than normal population. Commonly used drugs mainly include sulfasalazine, adrenocorticosteroids, etc., and the drugs have high toxic and side effects. Common Chinese patent medicines include Bupi Yichang Pills, etc., w...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/48A61K47/32A61K47/38A61K47/44A61P35/00A61P1/04A61K131/00
Inventor 高崇凯
Owner 惠州市九惠药业有限公司
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