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Colon-targeted drug delivery soft capsule and preparation method thereof

A colon-targeted drug delivery and soft capsule technology, which can be used in capsule delivery, pharmaceutical formulations, anti-tumor drugs, etc., can solve problems such as high technical requirements and limitations, achieve mature process conditions, simple preparation methods, and fill the development and application gaps. Effect

Active Publication Date: 2011-12-14
惠州市九惠药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as an oily drug, although there are products filled with hard capsules, due to the limitations of technology and equipment, there are few products in China that are industrialized
Soft capsules are easy to fill with oily drugs, but the technical requirements for enteric treatment are high, and there are no soft capsules for colon administration in China that have been developed and marketed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 1 Experimental materials

[0060] 1.1 Drugs and reagents

[0061] Drugs: Vitamin AD small capsules from Guangzhou Zhujiang Pharmaceutical Factory

[0062]Brucea javanica oil soft capsules, loading capacity 0.53g, self-made, conventional technology.

[0063] Reagents: absolute ethanol produced by Tianjin Fuyu Fine Chemical Co., Ltd., acetone produced by Tianjin Fuyu Fine Chemical Co., Ltd., diethyl phthalate produced by Tianjin Damao Chemical Reagent Factory, Tianjin Damao Chemical Castor oil produced by Reagent Factory, ethyl cellulose produced by Beijing Jingqiu Chemical Co., Ltd., cellulose acetate (cellulose diacetate) produced by Sinopharm Chemical Reagent Co., Ltd., Tween produced by Tianjin Damao Chemical Reagent Factory -80, acrylic resin III and II produced by Lianyungang Wantai Pharmaceutical Materials Co., Ltd., and Eudragit S100 produced by Rohm, Germany.

[0064] 1.2 Instruments

[0065] The BY-400 water chestnut type sugar coating machine produced by Ta...

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PUM

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Abstract

The invention discloses a colon-targeted drug delivery soft capsule, which comprises Brucea javanica oil soft capsule and a polymer coating film, and the polymer coating film is a pH-sensitive enteric coating containing ethyl cellulose or cellulose acetate vegetarian ingredients. The present invention provides precise composition of the polymer coating film, realizes that the coated soft capsule does not disintegrate in the buffer solution of pH<7, but disintegrates in the buffer solution of pH>7, and achieves the ideal colon The requirements of localized drug release, the preparation method is simple, and the process conditions are mature, which makes up for the development and application of soft capsules that do not have colonic drug delivery in China.

Description

technical field [0001] The invention relates to a drug preparation for the digestive tract, especially a preparation suitable for localized and targeted colon drug administration and a preparation method thereof. Background technique [0002] Colon cancer and rectal cancer are common malignant tumors of digestive tract. The incidence of colorectal cancer can reach 20 per 100,000, and the annual death rate of colorectal cancer in most provinces and cities in China accounts for 5-6 of all malignant tumor mortality. [0003] Ulcerative colitis or chronic nonspecific ulcerative colitis is a kind of chronic colitis with unknown cause. It is a common and frequently-occurring disease. In severe cases, it often causes pseudopolyps and even cancer. 5-10 times higher than normal population. Commonly used drugs mainly include sulfasalazine, adrenocorticosteroids, etc., and the drugs have high toxic and side effects. Common Chinese patent medicines include Bupi Yichang Pills, etc., w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/185A61K47/32A61K47/38A61K47/44A61P35/00A61P1/04A61K131/00
Inventor 高崇凯
Owner 惠州市九惠药业有限公司
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