Orally-administered hypoglycemic sweet potato leaf single prescription traditional Chinese medicine and preparation method thereof

A sweet potato leaf and blood sugar-lowering technology, which can be used in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of diabetes that have not been reported yet

Inactive Publication Date: 2008-04-30
YANSHAN UNIV
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  • Abstract
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AI Technical Summary

Problems solved by technology

Flavonoids are one of the active components of sweet potato leaves, and the research on the biological activity of sweet potato leaf flavonoids in treating diabetes has not been reported yet

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] The beneficial effects of the medicament of the present invention will be further elaborated below through experiments, and these experiments include pharmacodynamic experiments and clinical curative effect observation experiments of the medicament of the present invention.

[0014] In the experiment, pharmacological research is carried out on the medicine of the present invention, and its influence on blood sugar and blood lipids in mice is observed.

[0015] 1. Experimental materials:

[0016] 1.1 Animals: Clean-grade male Wistar rats, all aged 50-60 days and weighing 240-250g, were provided by the Institute of Animals of Union Hospital. Free drinking tap water, clean animal breeding room, suitable temperature and humidity, light 8-10h / d.

[0017] 1.2 Reagents: Sweet potato leaves, collected from Hebei in autumn, were identified as sweet potato leaves by plant experts; streptozotocin, a product of Sigma Company in the United States; TC, TG, LDL-C, HDL-C, SOD, MDA, an...

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PUM

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Abstract

The invention discloses a simple oral hypoglycemic traditional Chinese medicine of sweat potato leaf and process for preparation. Plant of sweat potato leaf is refluxed, extracted and concentrated through ethanol and ethanol extract is obtained. The ethanol extract after being absorbed through macroreticular absorbing resin is respectively eluted through distilled water, 10-20% ethanol and 40-60% ethanol, and the eluent liquid is concentrated and then is extracted through acetic ether. The extracting liquid is recycled and concentrated and extractum is obtained. The extractum is dried and the effective component of the sweat potato leaf--sweat potato leaf flavone is obtained. Tested by pharmacological experiment, sweat potato leaf flavone without toxic and side effects has the effect of reducing blood glucose and action time is lasting, thereby the invention can be used for curing type II diabetes and complication and provides a natural hypoglycemic medicament for non- insulin dependent diabetes mellitus (NIDDM).

Description

technical field [0001] The invention relates to a non-synthetic hypoglycemic drug for treating non-insulin-dependent diabetes mellitus (NIDDM, type II) of endocrine-metabolism system and preventing its complications, which is prepared from plants. Background technique [0002] Diabetes has become the third chronic non-communicable disease that endangers human health after tumors and cardiovascular and cerebrovascular diseases. According to data from the World Health Organization and the International Diabetes Federation, it is estimated that the total number of diabetic patients in the world will reach 333 million by 2025. According to the results of the census of diabetes in 19 provinces and cities in my country, the average life expectancy of the population is extended, the economic income increases and the lifestyle The total number of diabetic patients will increase by at least 1 million per year, of which NIDDM accounts for more than 90% of all patients. [0003] At pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/39A61P3/10A61K127/00
Inventor 李青旺赵蕊刘磊高大威
Owner YANSHAN UNIV
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