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Non-invasive measurement of blood analytes using thermal emission spectroscopy

An analyte and thermal emission technology, applied in the field of non-invasive measurement of blood components, can solve the problems of insufficient consideration of clinical accuracy and achieve the effect of increasing the accuracy of measurement

Inactive Publication Date: 2008-05-14
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these results have not been sufficiently considered for clinical precision

Method used

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  • Non-invasive measurement of blood analytes using thermal emission spectroscopy
  • Non-invasive measurement of blood analytes using thermal emission spectroscopy
  • Non-invasive measurement of blood analytes using thermal emission spectroscopy

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Experimental program
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Embodiment Construction

[0032] Referring to Figure 1, a simplified thermal emission spectroscopy (TES) based device 10 is shown in which a spatial light modulator (SLM) 11 such as a liquid crystal panel, a digital mirror display or a liquid crystal on silicon display (LCOS display) is coupled with a diffraction grating 12 use together.

[0033] Diffraction grating 12 spatially organizes blackbody radiation 13 (ie, thermal emission spectrum) emerging from a tissue sample (not shown) according to component wavelengths 14 . A grating 12 separates the multi-wavelength spatially mixed spectrum 13 and spatially rearranges the spectrum in the order of the wavelengths that make up the spectrum. This "organized spectrum" 14 is then focused onto the SLM 11 by a first lens system 15 .

[0034] By assigning gray levels to specific pixels of the SLM 11, various parts of the organized spectrum 14 can be analyzed. For example, darkening a set of pixels at a given location on the SLM 11 will prevent those waveleng...

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PUM

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Abstract

A system is disclosed for the non- invasive measurement of an analyte concentration in body tissue. The system comprises means (16) for detecting a thermal emission spectrum (13) emitted by the body tissue, such as a finger, and interference filtering means (11) , for spatially separating the thermal emission spectrum to create a plurality of spectral patterns and measuring in respect of each of a plurality of said spectral patterns a spectral intensity at a first, reference set of wavelengths, and a second set of wavelengths dependent on the analyte being measured. The concentration of the analyte is then determined from the spectral measurements.

Description

technical field [0001] The present invention relates to non-invasive measurement of blood components, especially but not limited to non-invasive measurement of blood sugar concentration. Background technique [0002] Concentration determination of most blood components, such as cholesterol and glucose, is currently done by invasive means. A blood sample is typically taken from a patient and forwarded to a laboratory or hand-held device where it is analyzed. This causes significant discomfort to patients, especially adolescents, and samples taken from patients may become contaminated requiring additional blood samples to be drawn. [0003] Although several methods for continuous, non-invasive blood analysis are being developed, only a few have been clinically tested against invasive methods. In fact, most techniques are still limited in the accuracy of their measurements. [0004] One of the methods of in vivo (ie, inside the body) testing that has been reported is a metho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/14532A61B5/015
Inventor A·范格什M·范赫佩恩M·巴利斯特雷里
Owner KONINKLIJKE PHILIPS ELECTRONICS NV