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Chloromycetin eyedrops with long shelf-lifeand preparation method thereof

A technology of chloramphenicol and eye drops, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve problems such as unfavorable use by patients and the shelf life of only one year.

Inactive Publication Date: 2008-05-21
张咏梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent CN1872038A has introduced drop pill type chloramphenicol eye drops and preparation method thereof, and it isolates chloramphenicol and aqueous solution by preparing main drug chloramphenicol into drop pills, thereby reaching the purpose of extending the period of validity of the drug, but due to The solubility of chloramphenicol in water is slightly soluble. When the above-mentioned drugs are used, they must be shaken for a long time to dissolve chloramphenicol, which is not conducive to the use of patients.
[0004] Chinese patent CN1163266C discloses a kind of eye drops for the treatment of conjunctivitis and keratitis eye disease, it improves its anti-staphylococcus aureus, escherichia coli sterilization rate, but the shelf life of the above products can only reach one year

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 2.5 grams of chloramphenicol, 1.5 grams of boric acid, 0.5 grams of borax, 6.5 grams of sodium chloride, and 0.1 grams of soybean isoflavones with a purity of 40%, add water to 1000 milliliters, and the pH value of the solution is 6.3.

Embodiment 2

[0032] Take 2.5 grams of chloramphenicol, 1.5 grams of boric acid, 0.5 grams of borax, 6.5 grams of sodium chloride, and 0.3 grams of soybean isoflavones with a purity of 80%, and add water to 1000 milliliters.

Embodiment 3

[0034] Take 2.5 grams of chloramphenicol, 1.5 grams of boric acid, 0.5 grams of borax, 6.5 grams of sodium chloride, and 0.5 grams of soybean isoflavones with a purity of 90%, and add water to 1000 milliliters.

[0035] Embodiment 1 result is as shown in table 1:

[0036] Table 1:

[0037] Accelerate 4 months

[0038] Embodiment 2 result is as shown in table 2:

[0039] Table 2:

[0040] Accelerate 4 months

[0041] Embodiment 3 results are as shown in table 3:

[0042] table 3:

[0043] Accelerate 4 months

[0044] p-nitrobenzaldehyde content (%)

[0045] Examples 1-3 show that when the purity of soybean isoflavones is 40-90% and the content of soybean isoflavones is 0.01-0.05%, the present invention can be realized.

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PUM

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Abstract

The invention discloses a chloramphenicol eye drop with long guarantee period, including chloramphenicol and buffer solution. The eye drop contains the soy isoflavone with the weight concentration of 0.01 to 0.05 percent and the purity of 40 to 90 percent. The chloramphenicol eye drop of the invention can not only be prepared according to the existing processing technique, but can also be prepared according to the following method: the preparation method of the invention includes preparation process and filling-sealing process. Compared with the prior art, the guarantee period of the invention can achieve more than 2 years, which is conducive to the production, sales and usage of the chloramphenicol eye drop, so the invention has great benefits for the creation of a conservation-oriented society.

Description

technical field [0001] The invention belongs to chloramphenicol eye drops and a preparation method thereof, in particular to chloramphenicol eye drops containing soybean isoflavones and a preparation method thereof. Background technique [0002] Chloramphenicol eye drops is a commonly used drug for the eyes. It is a drug recorded in the second part of the "Chinese Pharmacopoeia" in 2005. It was once used as an OTC Class A drug in the market. Its main ingredients are chloramphenicol, Buffers, bacteriostats, water, and sodium hyaluronate and glycerin are also added to chloramphenicol eye drops to enhance viscosity and improve retention time in the eyes. The usual shelf life of medicines is 2 years, but the shelf life of chloramphenicol eye drops can only reach 8-12 months, this is because chloramphenicol in chloramphenicol eye drops is easily decomposed into chloramphenicol Nitrobenzaldehyde, chloramphenicol diol and p-nitrobenzaldehyde are highly irritating to the eyes and a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/165A61K47/46A61K47/22A61P27/02
Inventor 张咏梅
Owner 张咏梅