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Hydroxyl radical carthamin yellow carthamus A soft capsule with high bioavailability and preparation method thereof

A technology of hydroxy safflower and soft capsules, which can be used in capsule delivery, medical preparations containing non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as poor fat solubility

Inactive Publication Date: 2008-05-21
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Because hydroxysafflor yellow A has good water solubility and poor fat solubility, it is insoluble in oily matrix. By preparing it into a phospholipid complex, the problem of solubility is solved, and in the presence of surfactants, the quality of soft capsules can be improved. more stable

Method used

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  • Hydroxyl radical carthamin yellow carthamus A soft capsule with high bioavailability and preparation method thereof
  • Hydroxyl radical carthamin yellow carthamus A soft capsule with high bioavailability and preparation method thereof
  • Hydroxyl radical carthamin yellow carthamus A soft capsule with high bioavailability and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Weigh 150mg of soybean lecithin and dissolve it in 5ml of tetrahydrofuran, heat to 40°C to dissolve it, add 50mg of hydroxysafflower yellow A, stir and reflux for 2 hours to obtain a yellow clear liquid, recover the solvent under reduced pressure, and dry to obtain hydroxyl Safflower yellow A phospholipid complex. Take phospholipids, hydroxysafflower yellow A and hydroxysafflower yellow A phospholipid complex for DSC analysis (attached Figure 1~3 ), the results show that there is a phase transition temperature of hydroxysafflower yellow A at 142.8°C, while the hydroxysafflower yellow A phospholipid complex cannot see the phase transition point of hydroxysafflower yellow A at 142.8°C, which proves the formation of hydroxysafflower yellow A Anthocyanin A phospholipid complex. Weigh 100mg of hydroxysafflower yellow A phospholipid complex and 100mg of Span-80 and dissolve them in 5g of caprylic / capric triglyceride to obtain the liquid medicine; take another 20g of gelatin...

Embodiment 2

[0044] Weigh 150mg of soybean lecithin and dissolve it in 5ml of ethyl acetate, heat to 60°C to dissolve it, add 30mg of hydroxysafflower yellow A, stir and reflux for 2 hours to obtain a yellow clear liquid, recover the solvent under reduced pressure, and dry Obtain hydroxysafflower yellow A phospholipid complex. Weigh 100 mg of hydroxysafflower yellow A phospholipid complex and 50 mg of Span-60 and dissolve them in 5 g of caprylic / capric monoglyceride to obtain the liquid medicine; take another 20 g of gelatin, 8 g of glycerin, and 20 g of water, and put them in a suitable container Heat to 70°C to dissolve, add 0.15g of sorbic acid and 0.015g of maleic acid, stir evenly, ultrasonically degas, keep warm at 60°C to obtain the rubber solution; take the above medicinal liquid and rubber solution, and press them with soft capsule production equipment Shaped and dried.

Embodiment 3

[0046] Weigh 300mg of soybean lecithin and dissolve it in 5ml of methanol, heat to 50°C to dissolve it, add 100mg of hydroxysafflor yellow A, stir and reflux for 3 hours to obtain a yellow clear liquid, recover the solvent under reduced pressure, and dry to obtain hydroxyl Safflower yellow A phospholipid complex. Weigh 100mg of hydroxysafflower yellow A phospholipid complex and 90mg of Span-83 and dissolve them in 5g of caprylic acid / capric diglyceride to obtain the liquid medicine; take another 20g of gelatin, 12g of glycerin, and 22g of water, and put them in a suitable container Heat to 70°C to dissolve, add 0.1g of sorbic acid and 0.01g of maleic acid, stir evenly, degas by ultrasonic, keep warm at 60°C to obtain the rubber solution; take the above liquid medicine and rubber solution, and press them with soft capsule production equipment Shaped and dried.

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Abstract

The invention relates to the field of pharmaceutical preparations, in particular to a hydroxy safflor yellow A soft capsule preparation with high bioavailability, the invention is characterized in that the invention consists of hydroxy safflor yellow A, oily matrix and surfactant, and the invention also discloses the preparation method.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a hydroxysafflower yellow A soft capsule preparation with high bioavailability and a preparation method thereof. Background technique [0002] Safflower is the dried flower of Carthamus tinctorious L., a plant of the genus Safflower in the Compositae family, and is a traditional Chinese medicine for promoting blood circulation and removing blood stasis. Its effects of promoting blood circulation, promoting menstrual flow, dispelling blood stasis and relieving pain are representative in traditional Chinese medicine. In modern medicine, it is an important traditional Chinese medicine for the prevention and treatment of coronary heart disease, myocardial infarction and cerebral thrombosis and other middle-aged and elderly diseases. [0003] The main ingredient in safflower that promotes blood circulation and removes blood stasis is hydroxysafflower yellow A, the structure ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/48A61K47/14A61K47/24A61P9/10
Inventor 平其能王淑静孙敏捷
Owner CHINA PHARM UNIV
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