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Method for further reclamation of L-tyrosine from effluent of L-cystine production

A technology of tyrosine and effluent, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of low product yield and low purity, achieve high yield, simple process, and less loss Effect

Active Publication Date: 2010-07-28
湖北新生源生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a method for further reclaiming L-tyrosine from the effluent of producing L-cystine, to solve the problems of low product yield and low purity, and to simplify the process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] For the exchange tower using granular activated carbon column as filler, the carbon column is treated to pH = 3-4 before each separation. In this example, the particle size of the carbon column is 5mm, and the model is 1200×4800. Collect the refined discharge liquid produced by protein hydrolysis to produce L-cystine, in which the content of L-tyrosine is 6.734kg / m 3 . The solution was adjusted to pH=2 with hydrochloric acid, at a flow rate of 2.5m 3 / h passes through the exchange tower, and the tower effluent is detected by the sulfuric acid formaldehyde test, and blue (carbon column saturation) occurs to stop the liquid intake, and then the 3% dilute NaOH solution is mixed with 2.0m 3 / h passes through the exchange tower, and receives the carbon column eluent 6m 3 , concentrated hydrochloric acid to neutralize the eluent to pH = 8.5, stir to crystallize, and centrifuge to obtain 126 kg of crude L-tyrosine. Pass 2.5% hydrochloric acid through the desorbed carbon co...

Embodiment 2

[0016] The same solution as Example 1, adjusted to pH=2.5 with liquid ammonia, with a flow rate of 2.0m 3 / h is passed through the exchange tower treated in Example 1, and the tower effluent is detected with sulfuric acid formaldehyde test, and blue color appears to stop the liquid intake, and then the flow rate is 2.0m 3 / h into 5% NaOH solution, collected eluate 6.5m 3 , concentrated hydrochloric acid to neutralize the eluent to pH = 7, stir to crystallize, and centrifuge to obtain 132 kg of L-tyrosine crude product. Pass 4% hydrochloric acid into the desorbed carbon column until the pH of the effluent = 1, and then pass Rinse with tap water until the pH of the effluent = 4, and wait for feeding. The obtained L-tyrosine crude product was decolorized and refined according to conventional methods to obtain a finished product of L-tyrosine with a dry weight of 75kg. The product has an optical rotation of -11.2°, a light transmittance of 96.7%, and a content of 100.2%. Take t...

Embodiment 3

[0018] The same solution as Example 1, adjusted to pH=3 with quicklime, with a flow rate of 2.0m 3 / h is passed through the exchange tower treated in Example 2, and the tower effluent is detected with sulfuric acid formaldehyde test, and blue color stops entering the liquid, and then with a flow rate of 2.0m 3 / h into 7% dilute NaOH solution, collected eluate 6m 3 , concentrated hydrochloric acid to neutralize the eluent to pH=5.5, stir to crystallize, and centrifuge to obtain 128 kg of L-tyrosine crude product. Pass 7% hydrochloric acid into the desorbed carbon column until the effluent pH=0.5, and then pass Rinse with tap water until the pH of the effluent = 3.5, and wait for feeding. The obtained L-tyrosine crude product was decolorized and refined according to conventional methods to obtain a finished product of L-tyrosine with a dry weight of 73kg. The product has an optical rotation of -11.4°, a light transmittance of 96.6%, and a content of 100.2%. The discharge liqu...

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PUM

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Abstract

A method of further recycling L-tyrosine from the discharge liquid of L-cystine production is that the collected refined discharge liquid of the L-cystine production by the proteolysis method is adjusted till the pH value is 2 to 3, and the discharge liquid flows through a granular active carbon column which is processed till the pH value is 3 to 4; the active carbon column is eluted by 3 percentto 7 percent NaOH solution; elution liquid is neutralized by concentrated hydrochloric acid till the pH value is 5.5 to 8.5; the crude product of the L-tyrosine is separated to be discolored and refined to obtain the finished product of the L-tyrosine. The present invention solves the problem of the prior production method that the L-tyrosine product has the low yield and the low purity.

Description

technical field [0001] The present invention relates to the production method of L-tyrosine, especially the method of producing this product by proteolytic route. Background technique [0002] L-tyrosine product is white powder crystal. The product can be recovered from the mixed mother liquid containing cystine obtained by protein hydrolysis or from the discharge liquid produced from L-cystine. The traditional production method is: adjust the recovered refined mother liquor for producing L-cystine to about pH=4.5, settle for about 20 hours, and filter to obtain the mixed crude product of L-cystine and L-tyrosine. The crude product is dissolved with dilute acid, and then the solution is neutralized with ammonia water by the isoelectric point method to separate the crude product of L-tyrosine, and the crude product of L-tyrosine is decolorized and refined to obtain the finished product of L-tyrosine. [0003] Publication No. CN1231284 titled "New Method for Separation and E...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/36C07C227/38
Inventor 王先兵史可贵肖国安章平王祥兵
Owner 湖北新生源生物工程有限公司