Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Szechuan lovage rhizome medicament compound, preparing method and application thereof

The technology of a composition and an astragalus extract, which is applied in the field of medicine, can solve the problems of large differences in the content of active ingredients, unstable curative effect, etc., and achieve the effect of unique pharmacological action

Inactive Publication Date: 2008-06-18
NAT INST OF PHARMA R & D CO LTD
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] One of the objectives of the present invention is to overcome the shortcomings of traditional Chinese medicines such as large differences in active ingredient content and unstable curative effect caused by the prescription of crude drug decoction pieces, and to provide a composition for extracting Ligusticum chuanxiong and Astragalus membranaceus

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Szechuan lovage rhizome medicament compound, preparing method and application thereof
  • Szechuan lovage rhizome medicament compound, preparing method and application thereof
  • Szechuan lovage rhizome medicament compound, preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 1 kg of decoction pieces of Rhizoma Chuanxiong, extract with 10L 50% ethanol under reflux, and extract 3 times for 2 hours each time. Combine the extracts, filter, concentrate until there is no alcohol smell, put on a macroporous resin column, wash with distilled water until sugar-free, that is, elute with 40% ethanol, collect, recover ethanol from the eluent, and dry it in vacuum to make the dry powder of the extract 235g.

[0025] Take 1kg of Astragalus decoction pieces, reflux extraction with 10L water, extract 3 times for 1 hour each time, combine the extracts, concentrate, put on a macroporous resin column, wash with distilled water until sugar-free, that is, elute with 40% ethanol, and then wash with 95% ethanol was eluted, collected, ethanol was recovered from the eluate, and 112 g of dry extract powder was prepared by vacuum drying.

Embodiment 2

[0027] Take 1 kg of decoction pieces of Rhizoma Chuanxiong, extract with 8L 90% ethanol under reflux, and extract 3 times for 1.5 hours each time. Combine the extracts, filter, concentrate until there is no alcohol smell, put on a macroporous resin column, wash with distilled water until sugar-free, that is, elute with 20% ethanol, collect, recover ethanol from the eluent, and dry it in vacuum to make the dry powder of the extract 201g.

[0028] Take 1kg of Radix Astragali decoction pieces, reflux extraction with 10L 30% ethanol, extract twice for 1 hour each time, combine the extracts, filter, concentrate until no alcohol smell, put on a macroporous resin column, wash with distilled water until sugar-free, that is Eluted with 20% ethanol, then eluted with 70% ethanol, collected, recovered ethanol from the eluate, and vacuum-dried to prepare 121 g of dry extract powder.

Embodiment 3

[0030] Take 1 kg of decoction pieces of Rhizoma Chuanxiong, extract twice with 10L of 70% ethanol under reflux, for 2 hours each time. Combine the extracts, filter, concentrate until there is no alcohol smell, put on a macroporous resin column, wash with distilled water until sugar-free, that is, elute with 30% ethanol, collect, recover ethanol from the eluent, and dry it in vacuum to make dry powder of the extract 215g.

[0031] Take 1kg of Astragalus decoction pieces, reflux extraction with 10L water, 1 hour each time, extract 3 times, combine the extracts, filter, concentrate, put on a macroporous resin column, first wash with distilled water until sugar-free, that is, elute with 20% ethanol , and then eluted with 50% ethanol, collected, and the eluate recovered ethanol, and dried in a vacuum to make 128g of dry extract powder.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an extraction combination of ligusticus wallichii franchet and radix astragali, and a preparation method and application. According to the weight of extractive,the mixture ratio between the ligusticus wallichii franchet and the radix astragali is 1:1 to 1:4 or 1:1 to 4:1; the specific preparation method is detailed in the Specification. The invention has the advantages that: the combination comprises saponin, flavonoid, alkaloid and various other biological active sites. The combination has a unique pharmacological effect on myocardial ischemia, and the curative effect is better than that of the exclusive use of the ligusticus wallichii franchet and the radix astragali; furthermore, the dose can drop about 1 / 50 than that of the crude drug. The invention can be made into a plurality of oral preparations and injection so as to be used in treating heart weak, weak heart Qi, obstruction of Qi in chest and heartache caused by qi stagnation and blood stasis, and myocardial ischemia.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a composition composed of chuanxiong and astragalus in a certain proportion, a preparation method thereof, and an application in the aspects of chest pain, heart pain and myocardial ischemia. Background technique [0002] Ischemic Heart Disease (IHD) is myocardial damage caused by changes in the coronary circulation of the heart, resulting in an imbalance between coronary blood flow and myocardial demand, including functional changes in coronary arteries or temperamental lesions. Acute transient or chronic coronary insufficiency and other myocardial ischemia (myocardial ischemia). The pathogenesis of ischemic heart disease is still inconclusive. Traditional Chinese medicine believes that ischemic heart disease should belong to the category of chest obstruction and heart pain, internal injuries of the seven emotions, stagnation of heart and liver qi; old age and infir...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/00A61P9/10
Inventor 郑礼苑可武陈牛燕宫麟
Owner NAT INST OF PHARMA R & D CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com