Method for refining tanshinoneIIA sodium sulfonate

A refining method and sodium sulfonate technology are applied in the preparation of steroids, chemical instruments and methods, steroidal compounds, etc., which can solve the problems of large solvent usage, ineffective effect, and insufficient purity for injections, etc., and achieve low cost, The effect of simple method and easy operation
CN101200489AInactive Publication Date: 2008-06-18YAOPHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YAOPHARMA CO LTD
Publication Date
2008-06-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a refining method of tanshinone II sulfonate. The method comprises the following procedures, firstly the crude tanshinone II sulfonate to be purified is added into the mixture solution of the organic solvent and water, heated to 40 to 60 DEG C, agitated to dissolve and filtered to remove the insoluble particles; secondly, the filtrate is slowly decreased to the temperature of 0 to 30 DEG C and crystallized and filtered; thirdly tanshinone II sulfonate with high purity is obtained after the vacuum drying. The contents of tanshinone II sulfonate can reach 99.5 percent and the quality can meet the purity requirement of raw medicine for injection by HPLC analysis. The method of the invention has the advantages of simple method, easy operation, low refining cost and being suitable for the industrialized production.
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Description

technical field

[0001] Invention related to Tanshinone II A The refining method of sodium sulfonate bulk drug. Background technique

[0002] Salvia miltiorrhiza Bye (Salvia miltiorrhiza Bye) is a traditional Chinese medicinal material commonly used in my country. It has a long history of application and has a history of nearly 2,000 years. It is an important commodity in the domestic and foreign medicinal material markets. This product is the dry root and rhizome of Salvia miltiorr hiza Bye. It is included in the first volume of the 2005 edition of "Pharmacopia of the People's Republic of China". Its application was first recorded in "Shen Nong's Materia Medica" in the Eastern Han Dynasty. The main ingredients are: furophenanthrenequinone pigments Tanshinone I, Tanshinone II A , tanshinone III, cryptotanshinone, salvianic acid, methyl tanshinate, isotanshinone I, isotanshinone II, isotanshinone, tanshinone, tanshinol I and tanshinol II, in addition, it also contains vita...

Claims

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