Application of hyperosmotic fluid composition in preparing medicament for improving wound healing
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A technology for anastomotic healing and composition, which is applied in the direction of drug combination, surgical drug, hydroxyl compound active ingredients, etc., and can solve the problems of not revealing the effect of hypertonic fluid composition, etc.
Inactive Publication Date: 2008-07-02
赵超英
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Problems solved by technology
However, this patent does not disclose the effect of the hypertonic fluid composition on promoting wound healing
Method used
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Embodiment 1
[0021] Prepare according to the following ratio:
[0022] Hydroxyethyl starch 7.6 g
[0023] Sodium chloride 4.2 g
[0024] Add water for injection to 100ml
[0025] Dissolve 7.6 g of hydroxyethyl starch in 100 ml of water for injection, add 0.5 g of activated carbon, stir and heat at 90°C for 15 minutes, filter, add 4.2 g of sodium chloride (medical pure) and stir to dissolve, add 0.5 to 1.0 g of active The carbon is stirred and heated at 90°C for 10 minutes, then filtered, and passed through a 0.6-0.8 micron microporous membrane. Fill the obtained filtrate into 20ml, 50ml, 100ml, 250ml, 370ml or 500ml glass ampoules, large infusion glass bottles or plastic bottles (bags), and then pass the cap to 1.05kg / cm 2 , Sterilize at 121-123°C for 15-30 minutes to obtain a hypertonic liquid pharmaceutical composition.
Embodiment 2
[0027] Prepare according to the following ratio:
[0028] Hydroxyethyl starch 8g
[0029] Sodium chloride 4.1 g
[0030] Normal saline to 100ml
[0031] 8 grams of hydroxyethyl starch and 4.1 grams of sodium chloride were dissolved in 100 milliliters of physiological saline, and activated carbon was used for adsorption decolorization, filtration, filling and sterilization according to the method described in Example 1, to obtain a hypertonic liquid pharmaceutical composition.
Embodiment 3
[0033] Prepare according to the following ratio:
[0034] Sodium chloride 5.1 g
[0035] Carboxymethyl starch 18 g
[0036] Add water for injection to 100ml
[0037] Dissolve 18 g of carboxymethyl starch and 5.1 g of sodium chloride in 100 ml of water for injection, and use activated carbon to adsorb decolorization, filter, fill and sterilize according to the method described in Example 1 to obtain a hypertonic liquid pharmaceutical composition.
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Abstract
The invention relates to an application of a hypertonic solution composition in the preparation of the drugs for promoting wound healing during the perioperative period, the composition is composed of 1.5 to 6.9 percent (w / v) one or more substances of sodium chloride, sodium bicarbonate, potassium chlorine, magnesium sulfate, calcium chloride and calcium gluconate, 3 to 18 percent (w / v) one or more substances of hydroxyethyl starch, dextran, carboxymethyl starch, polyvinyl pyrrolidone and gelatin derivatives and the rest amount of conventional injection liquid; the conditions are that the sodium chloride in the composition is not less than 1.5 percent (w / v), and the concentration of the sodium ions is not more than the concentration of the sodium ions in the 6.9 percent (w / v) of sodium chloride. The hypertonic solution composition can be dropped as the injection before, during and after the operation, the dosage is 100 to 1500ml per person per day, the invention can promote the wound healing after usage and has the advantages that the usage is safe and convenient, and the invention can be widely used in various types of surgical wounds or traumatic wounds (surfaces) and anastomosis, etc.
Description
(1) Technical field [0001] The invention relates to the application of a hypertonic liquid composition in preparing a medicine for promoting wound healing (2) Background technology [0002] Surgery is an important part of modern medicine. Among them, waiting for surgical wounds to heal and removing sutures is one of the post-surgery tasks in various surgical disciplines. How to promote the healing of surgical wounds and anastomoses is a problem faced by surgery. At present, people usually use isotonic fluid supplementation and infusion after surgery. It is often necessary to inject isotonic fluid of 2500~3000ml / day for several consecutive days. The infusion of exudate will affect the circulatory system of the surgical patient, increase the burden on the patient's heart and lungs, and thus affect the function of the organs. The method of using hypertonic fluid in the present invention proves that it can promote the healing of wounds (anastomoses), which is of positive significance...
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