Bone repairing material with marine organism as rough material and preparation technique thereof
A repair material and purpose technology, applied in medical science, prosthesis, etc., can solve the problems of high molding process requirements, complex synthesis process of artificial synthetic materials, simple manufacturing process, etc., and achieve the effect of good biocompatibility
Examples
Embodiment 1
[0024] Oyster shells are used as raw materials, and the oyster shells are cleaned by running water and ultrasonic waves with a frequency of 20KMz and 40W / L solution; the surface is treated with 1% hydrochloric acid and soaked for 6 hours; the cleaned oyster shells are cleaned by using a general medical grinder Pulverize to make the particle size about 100 mesh; mix the pulverized oyster shells with the excipient according to the ratio of 1:1, pressurize at 20KPa to form, and sterilize with ethylene oxide.
[0025] The beneficial effects of the present invention are:
[0026] 1) Oyster shells can be processed through the above process procedures to obtain active bone repair materials with good biocompatibility and able to meet clinical needs. In vitro experimental studies have shown that bone marrow stromal stem cells can adhere to the surface of the material, and can increase and differentiate over time, and the synthetic powder forms new hydroxyapatite crystals.
[0027] 2) ...
Embodiment 2
[0031] Using oyster shells near the river or offshore as raw materials, the oyster shells are cleaned with running water and ultrasonic waves of 40KMz, 70W / L solution; the surface is treated with a mixture of 1% hydrochloric acid, 1% acetic acid, and 1% citric acid, and soaked for 24 hours; Ordinary medical pulverizer, pulverize the cleaned oyster shells to make the particle size about 200 mesh; mix the pulverized oyster shells with excipients at a ratio of 3:1, pressurize at 50KPa to form, and sterilize with ethylene oxide .
[0032] The beneficial effects of the present invention are:
[0033] 1) Oyster shells can be processed through the above process procedures to obtain active bone repair materials with good biocompatibility and able to meet clinical needs. In vitro experimental studies have shown that bone marrow stromal stem cells can adhere to the surface of the material, and can increase and differentiate over time, and the synthetic powder forms new hydroxyapatite c...
Embodiment 3
[0038] Use oyster shells near the river or near sea as raw materials, and use flowing water and ultrasonic waves of 60KMz and 60W / L solution to clean the oyster shells; use 2% acetic acid for surface treatment and soak overnight; use ordinary medical pulverizers to clean the oyster shells Pulverize to make the particle size about 300 meshes; mix the pulverized oyster shells with the excipient according to the ratio of 4:1, pressurize at 70KPa to form, and sterilize with ethylene oxide.
[0039] The beneficial effects of the present invention are:
[0040] 1) Oyster shells can be processed through the above process procedures to obtain active bone repair materials with good biocompatibility and able to meet clinical needs.
[0041] In vitro experimental studies have shown that: bone marrow stromal stem cells can adhere to the surface of materials, and over time
[0042] The extension of time can increase the value and differentiate, and the synthetic powder can form new hydrox...
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Abstract
Description
Claims
Application Information
- IPC
- A61L27/36; A61L27/58
- Inventors
- 彭磊; 洪涛