Method for extraction separation of total anthraquinone compounds

A technology for anthraquinones and compounds, which is applied in the field of extraction and separation of total anthraquinone compounds in rhubarb, can solve the problems of ionic liquid loss, ionic liquid entry, and the extraction process cannot be applied in large-scale industrial applications, and achieves the effect of improving the extraction effect.

Inactive Publication Date: 2008-07-16
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, at present, the biggest difficulty in using ionic liquids to extract organic matter from aqueous solutions is the loss of ionic liquids. No matter how small the solubility of ionic liquids in water is, the extraction process will cause a part of ionic liquids to enter the water phase. Due to the high price of ionic liquids and their Unknown tox

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  • Method for extraction separation of total anthraquinone compounds
  • Method for extraction separation of total anthraquinone compounds

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Experimental program
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Effect test

Embodiment 1

[0019] Put 10 milliliters of rhubarb extract (mass concentration of emodin is 1.2 mg / mL) and 12 mg of 1-methyl-3-propionamidoimidazolium hexafluorophosphate in a 50 milliliter reaction bottle, at pH=9, temperature Stir on a magnetic stirrer for 3 hours at 25°C, then separate the organic phase from the water phase, analyze the mass concentration of emodin in the extract by HPLC, and calculate the content of emodin in the organic phase after extraction by subtraction It is 11.2mg, and the extraction rate is 93%.

Embodiment 2

[0021] Put 10 ml of rhubarb extract (mass concentration of emodin is 1.2 mg / mL) and 1.2 mg of 1-methyl-3-propionamidoimidazolium hexafluorophosphate in a 50 ml reaction bottle, at pH=9, temperature Stir on a magnetic stirrer for 5 hours at 25°C, then separate the organic phase from the water phase, analyze the mass concentration of emodin in the extract by HPLC, and calculate the content of emodin in the organic phase after extraction by subtraction It is 2.5mg, and the extraction rate is 21%.

Embodiment 3

[0023] Put 10 milliliters of rhubarb extract (mass concentration of emodin is 1.2 mg / mL) and 36 mg of 1-hexanoamido-3-octylamidoimidazole hexafluorophosphate in a 50 milliliter reaction bottle, at pH=5, Stir on a magnetic stirrer for 50 hours at a temperature of 5°C, then separate the organic phase from the water phase, analyze the mass concentration of emodin in the extract by HPLC, and calculate the emodin in the organic phase after extraction by subtraction The content is 10mg, and the extraction rate is 85%.

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Abstract

The invention discloses a method for extracting and separating a compound of total anthraquinone in rheum. The method takes an amides ionic liquid displayed in formula (1) as an extractant and extracts the compound of total anthraquinone in rheum from a rheum extract. In formula (1), R1, and R2 are respectively the amide of C1-C10 or alkyl of C1 to C10. L- is one of the followings: BF4-, PF6-, OAC-, CF3SO3-, and N (SO2CF3)2-. The invention takes the amides ionic liquid as the extractant to extract and separate the compound of total anthraquinone in rheum from the rheum extract, which improves the extracting effect. The ionic liquid can be repeatedly used, which is safe, stable and environment friendly. The invention is the most economical and practical environmental protection technology.

Description

(1) Technical field [0001] The invention relates to a method for extracting and separating total anthraquinone compounds of rhubarb. (2) Background technology [0002] Rhubarb (Radix et Rhizoma Rhei) is derived from Polygonaceae plants. It is cold in nature and bitter in taste. It is one of the commonly used traditional Chinese medicines in clinical practice. The chemical composition of rhubarb is relatively complex, and its main component is anthraquinone derivatives, and the main component is emodin. At present, the methods for extracting and separating the total anthraquinones of rhubarb include gelatin precipitation method, alcohol pH adjustment method, polyamide method and macroporous resin separation and purification method. In the past, the standard for selecting extraction agents in the extraction process was basically based on the extraction effect, and less consideration was given to environmental factors, which led to various problems such as strong volatility, h...

Claims

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Application Information

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IPC IPC(8): C07C50/34C07C46/10B01D11/04
Inventor 裴文姬登祥计建炳斯小阳
Owner ZHEJIANG UNIV OF TECH
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