Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for extraction separation of total anthraquinone compounds

A technology for anthraquinones and compounds, which is applied in the field of extraction and separation of total anthraquinone compounds in rhubarb, can solve the problems of ionic liquid loss, ionic liquid entry, and the extraction process cannot be applied in large-scale industrial applications, and achieves the effect of improving the extraction effect.

Inactive Publication Date: 2008-07-16
ZHEJIANG UNIV OF TECH
View PDF0 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the biggest difficulty in using ionic liquids to extract organic matter from aqueous solutions is the loss of ionic liquids. No matter how small the solubility of ionic liquids in water is, the extraction process will cause a part of ionic liquids to enter the water phase. Due to the high price of ionic liquids and their Unknown toxicity to the environment makes the extraction process currently unsuitable for large-scale industrial application
[0006] Therefore, in the present invention, the method for extracting and separating the total anthraquinones of rhubarb is studied by using amide ionic liquid as an extractant, which is a green chemical technology and has not been reported yet

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for extraction separation of total anthraquinone compounds
  • Method for extraction separation of total anthraquinone compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Put 10 milliliters of rhubarb extract (mass concentration of emodin is 1.2 mg / mL) and 12 mg of 1-methyl-3-propionamidoimidazolium hexafluorophosphate in a 50 milliliter reaction bottle, at pH=9, temperature Stir on a magnetic stirrer for 3 hours at 25°C, then separate the organic phase from the water phase, analyze the mass concentration of emodin in the extract by HPLC, and calculate the content of emodin in the organic phase after extraction by subtraction It is 11.2mg, and the extraction rate is 93%.

Embodiment 2

[0021] Put 10 ml of rhubarb extract (mass concentration of emodin is 1.2 mg / mL) and 1.2 mg of 1-methyl-3-propionamidoimidazolium hexafluorophosphate in a 50 ml reaction bottle, at pH=9, temperature Stir on a magnetic stirrer for 5 hours at 25°C, then separate the organic phase from the water phase, analyze the mass concentration of emodin in the extract by HPLC, and calculate the content of emodin in the organic phase after extraction by subtraction It is 2.5mg, and the extraction rate is 21%.

Embodiment 3

[0023] Put 10 milliliters of rhubarb extract (mass concentration of emodin is 1.2 mg / mL) and 36 mg of 1-hexanoamido-3-octylamidoimidazole hexafluorophosphate in a 50 milliliter reaction bottle, at pH=5, Stir on a magnetic stirrer for 50 hours at a temperature of 5°C, then separate the organic phase from the water phase, analyze the mass concentration of emodin in the extract by HPLC, and calculate the emodin in the organic phase after extraction by subtraction The content is 10mg, and the extraction rate is 85%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for extracting and separating a compound of total anthraquinone in rheum. The method takes an amides ionic liquid displayed in formula (1) as an extractant and extracts the compound of total anthraquinone in rheum from a rheum extract. In formula (1), R1, and R2 are respectively the amide of C1-C10 or alkyl of C1 to C10. L- is one of the followings: BF4-, PF6-, OAC-, CF3SO3-, and N (SO2CF3)2-. The invention takes the amides ionic liquid as the extractant to extract and separate the compound of total anthraquinone in rheum from the rheum extract, which improves the extracting effect. The ionic liquid can be repeatedly used, which is safe, stable and environment friendly. The invention is the most economical and practical environmental protection technology.

Description

(1) Technical field [0001] The invention relates to a method for extracting and separating total anthraquinone compounds of rhubarb. (2) Background technology [0002] Rhubarb (Radix et Rhizoma Rhei) is derived from Polygonaceae plants. It is cold in nature and bitter in taste. It is one of the commonly used traditional Chinese medicines in clinical practice. The chemical composition of rhubarb is relatively complex, and its main component is anthraquinone derivatives, and the main component is emodin. At present, the methods for extracting and separating the total anthraquinones of rhubarb include gelatin precipitation method, alcohol pH adjustment method, polyamide method and macroporous resin separation and purification method. In the past, the standard for selecting extraction agents in the extraction process was basically based on the extraction effect, and less consideration was given to environmental factors, which led to various problems such as strong volatility, h...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C50/34C07C46/10B01D11/04
Inventor 裴文姬登祥计建炳斯小阳
Owner ZHEJIANG UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com