Monoclone antibody of H5 subtype avian influenza virus haemagglutinin protein, or its combination liveness fragment and uses thereof

A monoclonal antibody and avian influenza virus technology, applied in the direction of antibodies, viral peptides, anti-animal/human immunoglobulin, etc., can solve the problems that cannot meet the needs of clinical testing
CN101220097AInactive Publication Date: 2008-07-16XIAMEN UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XIAMEN UNIV
Publication Date
2008-07-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a McAb that can be specifically binded with the HA protein of H5N1 avain influenza virus and a McAb that can prevent from at least 50 percent of McAb activity combining with the HA protein of H5N1 avain influenza virus, which can be used for detecting, diagnosing, preventing and treating the avain influenza virus, in particular to the H5N1 avain influenza virus. The invention also provides the relating hybridoma cell lines, the separated nucleic acid molecule and short peptide, as well as the drug combination, the medicine diagnosis equipment and the kit with the McAb included.
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Description

[0001] related application

[0001] The present invention application claims the priority right from the Chinese invention application 200610002312.1 submitted on January 26, 2006, and the entire content of this application is included in the present invention application. field of invention

[0002] The present invention relates to a monoclonal antibody that can specifically bind to the hemagglutinin (HA) protein of H5 subtype avian influenza virus, its conservative variant or active fragment, or the relevant coding sequence of its polypeptide or polypeptide analogue, or the resulting A cell line of the above-mentioned monoclonal antibody, and a method for using the antibody or fragment for diagnosis and treatment. Background technique

[0003] Since H5 avian influenza first broke out in geese on farms in Guangdong Province in my country in 1996 (Xu X et al., 1999, Virology), another strain of H5 virus derived from this virus has spread in poultry farms in Hong Kong ( April...

Claims

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