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Method for preparing high-purity beta-elemene by citronella oil byproduct

A technology of by-product, citronella oil, applied in distillation purification/separation, organic chemistry and other directions, can solve the problems of poor extraction stability of instruments and equipment, complex production equipment, limited source of raw materials, etc., to improve production efficiency and simple production operation steps , the effect of a wide range of raw materials

Inactive Publication Date: 2008-07-30
沈阳万爱普利德医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a kind of by-product of citronella oil in order to overcome the existing problems in the prior art, such as the limitation of high-content β-elemene raw material sources, complex production equipment and expensive cost, and poor extraction stability of instruments and equipment. The product is the starting material, a new method for the preparation of high-purity β-elemene

Method used

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  • Method for preparing high-purity beta-elemene by citronella oil byproduct
  • Method for preparing high-purity beta-elemene by citronella oil byproduct
  • Method for preparing high-purity beta-elemene by citronella oil byproduct

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A, get citronella oil by-product as raw material (beta-elemene content<5%);

[0032] b, put an appropriate amount of citronella oil by-products into a 3L vacuum still, turn on the condensed water for cooling, turn on the vacuum pump and heating device, control the vacuum to be 4-5mm Hg, and when the temperature of the heating kettle is 100°C, Distill all the initial fraction at 48-76°C; adjust the temperature of the heating tank to 138°C, collect the fraction at 88-110°C to obtain a primary distillation product;

[0033] c. Put the primary distillation product obtained in step b into a vacuum still, control the vacuum of the whole system to carry out vacuum distillation at 4-5mm Hg, and when the temperature of the vacuum still is 112°C, set the temperature at 77 The initial fraction at -91°C is all distilled; adjust the temperature of the vacuum still to 135°C, collect the fraction at 96-104°C, and obtain the secondary distillation product;

[0034] d. Put the secondar...

Embodiment 2

[0036] A, get citronella oil by-product as raw material (beta-elemene content<5%);

[0037] b, put an appropriate amount of citronella oil by-products into a 3L vacuum still, turn on the condensed water for cooling, turn on the vacuum pump and heating device, control the vacuum to be 1-2mm Hg, and when the temperature of the heating kettle is 92°C, Distill all the initial fraction at 40-70°C; adjust the temperature of the heating tank to 128°C, collect the fraction at 80-100°C, and obtain a primary distillation product;

[0038] c. Put the primary distillation product obtained in step b into a vacuum still, control the vacuum of the whole system to carry out vacuum distillation at 1-2mm Hg, when the temperature of the vacuum still is 102°C, set the temperature at 72 The initial fraction at -83°C is all distilled; adjust the temperature of the vacuum still to 124°C, collect the fraction at 88-94°C, and obtain the secondary distillation product;

[0039] d. Put the secondary di...

Embodiment 3

[0041] A, get citronella oil by-product as raw material (beta-elemene content<5%);

[0042] B, an amount of citronella oil by-products are packed in the decompression distillation still of L, open condensed water and cool off, open vacuum pump and heating device, control vacuum tightness is 9-10mm Hg, when the temperature of heating still is 105 ℃, Distill all the initial fraction at 56-85°C; adjust the temperature of the heating tank to 154°C, collect the fraction at 95-120°C, and obtain a primary distillation product;

[0043]c. Put the primary distillation product obtained in step b into a vacuum still, control the vacuum of the whole system to carry out vacuum distillation at 9-10mmHg, and when the temperature of the vacuum still is 113°C, set the temperature at 85- All the initial fractions at 98°C are distilled; adjust the temperature of the vacuum still to 155°C, collect the fractions at 112-120°C, and obtain the secondary distillation product;

[0044] d. Put the seco...

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Abstract

The invention provides a method for preparing Beta-elemene with a high purity from a by-product of citronella oil so as to improve the production ratio of the high purity Beta-elemene obtained from the initial raw material and reduce the production cost. The invention is characterized in that the citronella oil by-product with the Beta-elemene contents of no more than 5 percent is taken as the raw material. Rectification is carried out by adopting the vacuum distillation method and the Beta-elemene with a high content is then obtained; the Beta-elemene with a content of 95.0 to 99.9 percent is obtained by the preparation method of high vacuum distillation. The invention has the advantages of wide resources of raw material, simple device and equipment and low cost. The invention reduces the times of the rectification and shortens the operation time, thus improving the production ratio and being applicable to the industrial production.

Description

Technical field: [0001] The invention relates to a method for preparing high-purity β-elemene from by-products of citronella oil. technical background: [0002] Elemene is isolated from zedoary oil and citronella oil, and has been widely used to treat cancer. The earliest anticancer drug was zedoary oil injection made from zedoary oil, which can only be used locally The treatment of cervical cancer by tumor drug administration has a long course of treatment and inconvenient administration operation, while other various cancers cannot be effectively treated with this injection. In order to solve the problem of the limitation of the use of zedoary oil injection, people have separated elemene with fixed proportioning components from zedoary oil and citronella oil to make elemene injection. In addition to local tumor administration and regional administration, the milk injection can also be injected intravenously, and can treat cervical cancer, brain tumor, digestive tract mali...

Claims

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Application Information

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IPC IPC(8): C07C13/19C07C7/04
Inventor 李淑斌孙敏鸽项银娟周莉宁红黄海
Owner 沈阳万爱普利德医药科技有限公司
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