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Method for knitting degradable heart atrial septal defect plugging device

A technology of atrial septal defect and occluder, which is applied in the field of medical devices and can solve problems such as the lack of preparation methods

Inactive Publication Date: 2008-08-06
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its shortcoming is that there is no discussion on the compilation method

Method used

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  • Method for knitting degradable heart atrial septal defect plugging device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Take 36 PLLA (poly-L-lactic acid) monofilaments and weave the occluder according to the planar method. First, a mold with three rings of steel needles is made on a plane, and then the PLLA monofilament is folded and wound, braided and shaped, and then heat-set. After 4 weeks of storage, the shape remained intact, and the resilience and clamping force met the requirements.

[0038] Further animal experiments were used to implant the shaped occluder woven by this method into the body of experimental dogs, and it was found that the degradable occluder could maintain its clamping force for a long time without falling off. It shows that the occluder obtained by this planar weaving method can replace the metal occluder.

Embodiment 2

[0040]Take 36 PBO (polyphenylene benzobisoxazole) monofilaments and weave them into a double umbrella occluder according to the planar method. Firstly, a mold with three rings of steel needles is made on the plane, and then the PBO monofilaments are folded back Winding, weaving and forming, then adding 4 alloy wires on the surface according to the method shown in Figure 2, and finally heat setting. After the production is completed, the occluder is introduced into the body of the experimental dog through the delivery device for animal experiments.

[0041] During the experiment, the growth of the dog was good, and no complications occurred. This kind of occluder is firmly clamped on the defect site and will not fall off easily.

[0042] After 30 days, the animals were observed under a scanning electron microscope, and it can be found that the PBO part of the occluder stent has been degraded to a considerable extent in the SEM photos. After 6 months, the PBO monofilament part...

Embodiment 3

[0044] Take 36 polycaprolactone monofilaments, first make a mold with three rings of steel needles on the plane, then make the polycaprolactone monofilaments turn back and wind, braid and shape, and then heat-set. After 4 weeks of storage, the shape remained intact, and the resilience and clamping force met the requirements.

[0045] Further animal experiments were used to implant the shaped occluder woven by this method into the body of experimental dogs, and it was found that the degradable occluder could maintain its clamping force for a long time without falling off. It shows that the occluder obtained by this planar weaving method can replace the metal occluder.

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Abstract

The invention relates to a method for weaving degradable atrial septal defect occluder, which belongs to a medical apparatus technical field and comprises a step of mould manufacturing in which the figuration of the atrial septal defect occluder comprises two discs and a waist part between the two discs; when the mould is manufactured, numeral values are chosen according to the three parts; three concentric circles are cut out on a steel plate and dotted at a certain distance and then steel needles are inserted to the corresponding positions; the weaving method also comprises weaving process of polymeric wires in which two groups of polymeric wires with biodegradability and biocompatibility are reversely folded and wound respectively in levogyrate and dextrogyrate directions by the steel needles to form petal-shaped discs with two upper-and-lower layers; finally, the two groups of polymeric wires are bound together and then set. The method for weaving the degradable atrial septal defect occluder adopts a plane weaving method characterized by the simple manufacture of mould and being more suitable for polymer molding; the elasticity and the chucking power of the woven degradable atrial septal defect occluder are obviously improved.

Description

technical field [0001] The invention relates to a manufacturing method of a device in the technical field of medical devices, in particular to a weaving method of a degradable atrial septal defect occluder. Background technique [0002] Seundum atrial septal defect (hereinafter referred to as ASD) belongs to a kind of congenital heart disease, and its lesion characteristic is that the interval between the left and right atria of the heart cannot be closed normally. Because the blood pressure of the left atrium is higher than that of the right atrium in normal people, under pressure, blood from the left atrium will flow into the right atrium, resulting in a decrease in blood volume in the systemic circulation. At the same time, the burden on the right heart system increases, and the organs related to the pulmonary circulation cause lesions. The occluder can be used for interventional treatment of ASD. In 1976, King and Mills first reported that the secundum ASD can be blocke...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61B17/00A61B17/03A61L33/00A61L27/00
Inventor 孙康窦红静王一涵李奋孙锟
Owner SHANGHAI JIAO TONG UNIV
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