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Preparation technique for extracting high pure hesperidin by cold impurity-removing one-step method

A preparation process and high-purity technology, which is applied in the preparation of sugar derivatives, chemical instruments and methods, and medical preparations containing active ingredients, etc., can solve the problems of complex process, high production cost, low yield, etc. Simple and practical, low cost, high yield effect

Inactive Publication Date: 2008-08-06
HUNAN BOTE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Extracting high-purity and low-cost hesperidin from Citrus aurantii Fructus, Fructus Aurantii Fructus, Green Peel, Pomelo Peel, and Tangerine Peel has always been a scientific research problem. Alcohol precipitation method" or "alcohol extraction and water precipitation method", these methods have complicated process, low yield, poor quality, high production cost (yield is 13.0%, content is about 90.0%), and environmental protection management is difficult

Method used

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  • Preparation technique for extracting high pure hesperidin by cold impurity-removing one-step method
  • Preparation technique for extracting high pure hesperidin by cold impurity-removing one-step method
  • Preparation technique for extracting high pure hesperidin by cold impurity-removing one-step method

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Embodiment Construction

[0014] Process flow of the present invention is as follows:

[0015]

[0016]

[0017]

[0018]

[0019] The preparation process for extracting high-purity hesperidin by cold removal of impurities in one-step method is as follows:

[0020] 1. Grind citrus aurantium, citrus citrus, green peel, pomelo peel, tangerine peel and other raw materials into granules, add 0.04M--0.06M NaOH solution to soak and remove impurities, the amount of NaOH solution is 10-12 times that of raw materials, and the time is 5- 8 hours.

[0021] 2. Then add 0.28M-0.32M Ca(OH) 2 The solution is subjected to percolation extraction, Ca(OH) 2 The consumption of the solution is 10-12 times of the raw material, and the time is 6-8 hours.

[0022] 3. Heat the extract to 60-65°C for acidification and crystallization, adjust the pH value to 3.5-6.5 with 31.0% industrial hydrochloric acid solution, and stand for crystallization.

[0023] 4. Separating the crystallization solution,...

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Abstract

The invention discloses a preparation method for extracting high-purity hesperidin via cold purification one-step method, which comprises breaking raw materials, adding low-density alkali solution to purify and extract, heating, acidifying and crystallizing, separating crystals and drying to obtain hesperidin. The invention uses cold purification one-step method to extract high-purity hesperidin to replace water extraction alcohol deposition method or alcohol extraction water deposition method of orange core, orange case, green tangerine orange peel, pomelo ped and dried orange peel, while the content is 96.0% or more and the yield is 25.0% or more, which are both 5-8% higher than traditional methods. Compared with the prior art, the preparation method for extracting high-purity hesperidin has simple process, low cost, high purity and yield, thus is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical fields of production and processing of medicinal materials and medicines, in particular to a preparation process for extracting high-purity hesperidin, an active ingredient of medicines. Background technique [0002] Citrus aurantium, Fructus aurantium, green peel, pomelo peel, and tangerine peel are commonly used raw materials in Chinese medicine decoction pieces. Its main flavonoids are hesperidin, nobiletin and neohesperidin. The hesperidin extracted from Citrus citrifolia medicinal materials has the functions of maintaining the normal permeability of blood vessels, increasing the resistance of capillaries, inhibiting the increase of blood cholesterol and preventing arteriosclerosis, etc. It is widely used in medicine such as hypertension treatment It can also be used in health care, beverage and food additives. Extracting high-purity and low-cost hesperidin from Citrus aurantii Fructus, Fructus Aurantii Fruc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08A61K36/752
Inventor 陈世军李青
Owner HUNAN BOTE SCI & TECH
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