Eyedrops for curing eye affection and uses thereof

A technology for eye infections and eye drops, which is applied in the direction of local antibacterial agents, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of reducing bacterial adsorption and bactericidal ability, and achieve reduction The probability of serious adverse reactions, the effect of prolonging the dosing interval and increasing the intensity of action

Inactive Publication Date: 2008-08-13
四川川投医药生物技术有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(3) With the increase of molecular weight, the degree of curling and entanglement of chitosan molecular chains increases, so that the effective gene N is embedded in it, reducing the adsorption and bactericidal ability of bacteria

Method used

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  • Eyedrops for curing eye affection and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Weigh 2.5 million units of amikacin (2.5 g as amikacin), 2.0 g of carboxymethyl chitosan, 1.5 g of citric acid, 7.5 g of sodium citrate, 1.0 g of sodium bisulfite, chlorine Add 4.0 g of sodium chloride and 0.1 g of benzalkonium chloride to 800 ml of water for injection, stir to dissolve, adjust the pH to 7.0 with 3 mol / L sulfuric acid and 1 mol / L sodium hydroxide solution, add water for injection to 1000 ml, and pass through a hole with a diameter of 0.22 Sterilize and filter with a micron microporous membrane, and aseptically dispense into plastic eye droppers. The eye drops have a pH of 7.0.

Embodiment 2

[0040] Take by weighing 2.5 million units of amikacin (2.5g in amikacin), carboxybutyl chitosan 2.0g, disodium hydrogen phosphate 17.9g, sodium dihydrogen phosphate 2.6g, sodium bisulfite 1.0g, Add 4.3g of sodium chloride and 0.1g of benzalkonium chloride to 800ml of water for injection, stir to dissolve, adjust the pH to 6.5 with 10% dilute hydrochloric acid and 1mol / L sodium hydroxide solution, add water for injection to 1000ml, and Sterilize and filter through a 0.22-micron microporous membrane, and dispense aseptically into plastic eye droppers. The eye drops have a pH of 6.5.

Embodiment 3

[0042] Weigh 2.5 million units of amikacin (2.5g in terms of amikacin), 2.0g of hydroxyethyl chitosan, 0.46g of acetic acid, 2.39g of sodium acetate, 1.0g of sodium metabisulfite, 4.2g of sodium chloride, Add 0.2 g of phenethyl ester to 800 ml of water for injection, stir to dissolve, adjust the pH to 6.2 with 3 mol / L sulfuric acid and 1 mol / L sodium hydroxide solution, add water for injection to 1000 ml, and pass through a microporous membrane with a pore size of 0.22 microns Sterilized and filtered, aseptically dispensed into plastic eye droppers. The pH of the eye drops is 6.2.

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Abstract

The invention discloses an eye drop which mainly contains amikacin or amikacin salt and chitosan or the derivative of chitosan. The eye drop comes into being through the dissolving of a medicine compound into the injection water which is then added with leakage pressure adjusting agent, pH value adjusting agent, acid-bases buffer, chemical inhibitor and bacteriostatic agent, then the addition of the full dose of injection water after the dissolving, then the filtering and sterilization of the solution, with the finished product obtained finally after the canning and sealing. The invention, on one hand, reduces the dosage of amikacin through the coordinate antibacterial action of chitosan, the derivative of chitosan and the amikacin, thus reducing the toxic and side effect and particularly reducing the toxicity to ears and kidneys. On the other hand, the invention prolongs the time for which the medicine stays in the eyes through taking advantage of the solution with a certain viscosity obtained after the dissolving of chitosan and the derivative of chitosan into the water, thus improving the use efficiency of the medicine, reducing the medicine using times and prolonging the intervals for medicine using. The invention has a good result in curing the eye infection caused by sensitive bacteria, such as conjunctivitis, keratitis, sclerotitis, etc.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition for treating eye infection, specifically, the present invention relates to a kind of eye drops containing amikacin or its salt and chitosan, and containing amikacin or its salt and chitosan Eye drops and applications of chitosan derivatives. Background technique [0002] Amikacin and its salts (such as amikacin sulfate) are aminoglycoside antibiotics, which are currently commonly used anti-infective drugs in clinical practice. Their mechanism of action is to act on the 30S subunit of bacterial ribosomes to inhibit bacterial protein synthesis. [0003] Amikacin and its salts are mainly suitable for: Pseudomonas aeruginosa and other Pseudomonas, Escherichia coli, Proteus (indole-positive and indole-negative), Pruvidenella, Klebsiella, Enterobacter Bacteremia, bacterial endocarditis, sepsis (including neonatal sepsis), respiratory tract infection, bone and joint infection, central nerv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61K31/7036A61K47/10A61K47/02A61P27/02A61P31/02
Inventor 朱晓茂莫兆明余安国
Owner 四川川投医药生物技术有限责任公司
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