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Intelligent non-contact type minim biological reagent distribution method and its dispensing system

A non-contact, biological reagent technology, applied in precise distribution, a variety of reagents for intelligent, trace, rapid field, to achieve rapid fault real-time monitoring and diagnosis, less pollution, strong reagent viscosity adaptability effect

Inactive Publication Date: 2008-09-17
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The distribution methods mentioned above all need experience and repeated test operations for the adjustment of distribution parameters, calibration

Method used

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  • Intelligent non-contact type minim biological reagent distribution method and its dispensing system
  • Intelligent non-contact type minim biological reagent distribution method and its dispensing system
  • Intelligent non-contact type minim biological reagent distribution method and its dispensing system

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Experimental program
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Embodiment Construction

[0016] Below in conjunction with accompanying drawing, the present invention will be further described:

[0017] In this embodiment, a set of non-contact trace reagent dispensing method is developed by adopting the combination of pressure and electromagnetic valve. The dispensing system is mainly composed of injection pump, 4-2 injection valve, pressure storage reagent bottle, pressure adjustment system, solenoid valve, motion platform, sensor and intelligent operation control system and other parts. When the system is initially working, the injection valve is biased to the right, and the motor drives the syringe piston to move downward to draw the system liquid from the reagent bottle. Then the injection valve is biased to the left, and the motor drives the piston to move upward to fill the reagent into the pipeline system. Repeat several times to complete the cleaning and filling of the pipeline. When the reagent is sucked, the injection valve is turned to the left, the sol...

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Abstract

The invention provides a intelligent non-contact type method for distributing trace biology agent and distributing system. A micro-flow detecting sensor is integrated on the distributing system by combining the MEMS technique and the intelligent control method and presupposing a great variety of knowledge information are used to perform the self-adapting automatic and intelligent adjustment of all kinds of the distribution parameters and strategies during high pass rapid cycle distribution process, therefore the accurate, trace agent not-contact type distribution can be realized direct towards all kinds of viscosity agent and all kinds of external condition effects. The automatic and intelligent adjustment of control parameters and the fault real-time monitoring and diagnosing function can be quickly performed to prevent the factors variation such as remain agent amount, environment temperature, agent viscosity or the like from influencing the distribution precision, so as to really ensure the exact size trace agent distribution, therefore the accuracy and reliability of the agent distribution can be increased. The distributing system has function of automatic calibration and searching the optimal control parameter, high agent viscosity adaptation character to satisfy the distribution requirement of the extensive volume (nanoliter to milliliter).

Description

(1) Technical field [0001] The invention relates to the technical field of bioengineering, in particular to a method for intelligent, trace, rapid and precise distribution of various reagents in a high-throughput operation process. (2) Background technology [0002] Biological reagent processing technology is one of the most commonly used experimental methods in life science experiments, and plays a vital role in protein crystallization, drug screening, biochemical experiments and other bioengineering technology fields. For example, in the process of obtaining protein crystals, it is necessary to optimize the crystallization conditions such as pH value, ionic strength, specific concentration of salt, reducing agent and detergent, and the accuracy and speed of biological reagent absorption, transfer and micro-dispensing operations become constraints on protein structure. The main bottleneck in the development of assay methods; in the field of drug research, high-throughput sc...

Claims

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Application Information

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IPC IPC(8): G01N35/10G01N33/48
Inventor 陈立国孙立宁刘亚欣陈涛
Owner HARBIN INST OF TECH
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