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Partition type tissue engineering spinal cord

A tissue-engineered spinal cord, partitioned technology, applied in the field of artificial spinal cord, can solve the problems of affecting fiber extension neuron migration, repair effect discount, disordered growth and other problems

Inactive Publication Date: 2008-10-08
NANTONG UNIVERSITY
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Problems solved by technology

Therefore, in such a scaffold material, even if the ascending and descending fiber bundles located in the peripheral white matter of the spinal cord are regenerated, they can only grow in mismatched or even misplaced channels or micropores, resulting in that the regenerated nerve fibers cannot be regularly distributed in the corresponding channels. The growth and extension of the region can only grow in a disorderly and disorderly manner, which eventually leads to the intertwining of the upper and lower regenerative fibers and affects the extension of other fibers or the migration of neurons, greatly reducing the repair effect

Method used

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  • Partition type tissue engineering spinal cord

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Embodiment Construction

[0014] A partitioned tissue-engineered spinal cord, including an extraspinal duct 1 and a central duct 2. A gray matter duct 3 with the same shape as the gray matter of the spinal cord is arranged in the extraspinal duct. Corresponding conduits 4 are provided.

[0015] Extraspinal catheters degrade less rapidly than other catheters. In the ducts in the white matter area, there is a fibrous scaffold. The chemical substance constituting the catheter is one or a mixture of chitosan, chitin, polyglycolic acid, polycaprolactone, polyamino acid, amino polysaccharide, collagen, and polylactic acid. Contain therapeutic cytokines in the catheter. The therapeutic cytokine is one or more of neurotrophic factor-3, brain-derived neurotrophic factor, and glial cell-derived neurotrophic factor. The catheter contains therapeutic drugs.

[0016] The seed cells constituting the partitioned tissue-engineered spinal cord are one or more of bone marrow stromal stem cells, neural stem cells, Sc...

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Abstract

The invention discloses a zoning tissue engineering spinal cord which comprises a spinal external catheter and a central catheter. A gray matter catheter which is provided with the same shape as spinal gray matter is arranged in the spinal external catheter. Corresponding catheters are respectively arranged in a white matter region according to the geometric shapes of uplink fiber bundles and downlink fiber bundles. The zoning tissue engineering spinal cord can play the role of correct guidance and lead to the result that the spinal gray matter, white matter and the uplink fiber bundles and the downlink fiber bundles in the white matter respectively grow in different regions.

Description

Technical field: [0001] The invention relates to an artificial spinal cord. Background technique: [0002] With the process of social modernization and the acceleration of people's life rhythm, there will inevitably be more traffic accidents, high-altitude falls, sports accidents and other incidents. At the same time, frequent local wars, violent incidents and natural disasters such as earthquakes will cause spinal cord injuries. (spinal cord injury, SCI) patients are increasing. Although there is no accurate data on the incidence of SCI in various countries, it is generally estimated at 20-60 people / 1 million people / year. SCI is an injury to the central nervous system with a high morbidity rate and serious consequences. The injury site mostly occurs in the spinal cord of the cervical and lumbar segments, which will cause loss of motor and sensory functions below the level of injury, and at the same time bring chronic pain. even mental disorders. Due to the high incidence...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61F2/44A61L27/50A61L27/14A61K35/12C12N5/00
Inventor 王晓冬顾晓松杨宇民姚健吕广明林巍巍陈雪李奕
Owner NANTONG UNIVERSITY
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