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Soft capsule of humifuse spurge and preparing method thereof

A technology of Dijincao and soft capsules, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. It can solve the problems of large dosage, slow drug release, and difficulty in disintegration and absorption. less, high total flavonoid content, and clear active ingredients

Inactive Publication Date: 2008-10-08
BEIJING SUNHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing Dijincao preparations are ordinary capsules and tablets, but the extract used in the existing dosage forms is the ethanol crude extract of Dijincao, which has miscellaneous components and large dosage, and the release speed of ordinary preparations in the body is slow, and it is not easy to collapse. desorption

Method used

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  • Soft capsule of humifuse spurge and preparing method thereof
  • Soft capsule of humifuse spurge and preparing method thereof
  • Soft capsule of humifuse spurge and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Dijincao extract (obtained according to the instructions) 60g

[0030] Propyl gallate 0.3g

[0031] Tween-80 40g

[0032] soybean oil 200g

[0033] Preparation Process:

[0034] Grind the extract of Dijincao, pass through a 200-mesh sieve, and set aside.

[0035] Take part of the soybean oil, the amount is enough to fully moisten all the powdered extracts of Dichrysus chinensis, add propyl gallate and Tween-80, mix well, pour the powder into the mixture, and stir as you add, until completely mixed.

[0036] Then add the remaining amount of soybean oil, and stir while adding until completely mixed, degassed, and set aside.

[0037] The above-mentioned materials are made into soft capsules with a soft capsule packaging machine, washed, dried, and compressed into 1000 Dijincao soft capsules. The measured disintegration time is 10`30``, and the dissolution rate in 5 minutes is 80.6%.

[0038] The following examples provide the soft capsule prescription composition, and...

Embodiment 2

[0040] Prescription (prescription quantity of 1,000 tablets)

[0041] Glycyrrhizae extract 75g

[0042] Propyl gallate 0.4g

[0043] Tween-80 35g

[0044] soybean oil 190g

[0045] The measured disintegration time was 11`27``, and the dissolution rate in 5 minutes was 79.9%.

Embodiment 3

[0047] Prescription (prescription quantity of 1,000 tablets)

[0048] Dijin grass extract 45g

[0049] Propyl gallate 0.45g

[0050] Tween-80 45g

[0051] soybean oil 210g

[0052] The measured disintegration time was 12`47``, and the dissolution rate in 5 minutes was 80.1%.

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Abstract

The invention relates to a humifuse euphorbia extract humifuse euphorbia soft capsule and processes for preparing the soft capsule. The humifuse euphorbia soft capsule consists of total flavonoid extract, antioxidant, encapsulation stabilizer and diluent. The humifuse euphorbia soft capsule has good appearance and stability. Compared with the existing humifuse euphorbia preparation, the humifuse euphorbia soft capsule has the characteristics of more homogeneous content and higher bioavailability and absorption rate, etc.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a Dijincao extract soft capsule and a preparation method thereof. Background technique [0002] Dijincao is the whole plant of Euphorbia himifusa Willd., also known as Xuejianshou, red stem grass, paving grass, milk grass, etc. It is born in wilderness wasteland, field road Besides, resources are abundant and widely distributed. Dijincao belongs to the traditional Chinese medicine of clearing away heat and detoxifying. It has the effects of clearing away heat and detoxifying, promoting blood circulation and stopping bleeding, promoting dampness and clearing milk. Water decoction and tincture have good curative effect on bacillary dysentery and enteritis. Its main components are flavonoids and tannins, among which there are more tannins in the leaves. The existing Dijincao preparations are ordinary capsules and tablets, but the extract used i...

Claims

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Application Information

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IPC IPC(8): A61K36/47A61K9/48A61K47/44A61P1/12A61P31/12A61P7/04A61P15/00A61K47/10A61K47/14A61K47/26A61K47/38
Inventor 张树祥龚玉萍
Owner BEIJING SUNHO PHARMA
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