Artificial joint medium layer and method of preparing the same

An artificial joint, medium layer technology, applied in joint implants, joint implants, medical science and other directions, can solve the problem of poor biological activity of hydrogels, and achieve the goal of promoting nutrient transmission, reducing friction loss, and inducing bone. effect on cell proliferation

Inactive Publication Date: 2008-10-08
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bioactivity of the hydrogel itself is poor

Method used

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  • Artificial joint medium layer and method of preparing the same
  • Artificial joint medium layer and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1) Prepare 1mol / L Ca(NO 3 ) 2 and P(C 2 h 5 O) 3 Ethanol solution, respectively get 400ml and 240ml and slowly mix in a 1L beaker, stir evenly, let stand for 30min, take the upper clear night, get nano-hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ] (HA) sol precursor solution.

[0029] 2) The commercial titanium alloy was cut into small discs of Φ15mm×2mm, the surface was successively polished with 360, 600, 1200 and 1500# sandpaper, and then ultrasonically cleaned in ethanol and acetone for 5 minutes respectively.

[0030] 3) Immerse the treated titanium alloy sheet vertically in the precursor solution of HA sol, let it stand for 3min, lift it up vertically at a pulling speed of 2cm / min, then dry it in a vacuum oven at 150°C for 15min, and then dry it in a vacuum oven. Heat it in the furnace to 500°C, keep it warm for 15 minutes, and then cool it down in the furnace. Repeat 5 times, heat treatment in vacuum furnace at 1100°C for 60 min for the last time, and cool in...

Embodiment 2

[0041] 1) Prepare 1.5mol / L of Ca(NO 3 ) 2 and P(C 2 h 5 O) 3 Ethanol solution, respectively take 300ml and 180ml and mix slowly in a 500mL beaker, stir evenly, let stand for 20min, take the upper clear night, and obtain nano-hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ] (HA) sol precursor solution.

[0042] 2) The commercial titanium alloy was cut into small discs of Φ15mm×2mm, and the surface was successively polished with 360, 600, 1200 and 1500# sandpaper, and then ultrasonically cleaned in ethanol and acetone for 10 minutes respectively.

[0043] 3) Immerse the treated titanium alloy sheet vertically in the precursor solution of HA sol, let it stand for 2min, lift it up vertically at a pulling speed of 4cm / min, then dry it in a vacuum oven at 140°C for 10min, and then dry it in a vacuum oven. Heat it in the furnace to 450°C, keep it warm for 10 minutes, and then cool it down in the furnace. Repeat 3 times, heat treatment in vacuum furnace at 1000°C for 80 min for the l...

Embodiment 3

[0048] 1) Prepare 2mol / L Ca(NO 3 ) 2 and P(C 2 h 5 O) 3 Ethanol solution, respectively take 500ml and 300ml in a 500mL beaker and mix slowly, stir evenly, let stand for 40min, take the upper clear night, get nano-hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ] (HA) sol precursor solution.

[0049] 2) The commercial titanium alloy was cut into small discs of Φ15mm×2mm, the surface was successively polished with 360, 600, 1200 and 1500# sandpaper, and then ultrasonically cleaned in ethanol and acetone for 5 minutes respectively.

[0050] 3) Immerse the treated titanium alloy sheet vertically in the precursor solution of HA sol, let it stand for 1min, lift it up vertically at a pulling speed of 2cm / min, and then dry it in a vacuum oven at 160°C for 20min, then dry it in a vacuum oven. Heat it in the furnace to 550°C, keep it warm for 20 minutes, and then cool it down in the furnace. Repeat 10 times, heat treatment in vacuum furnace at 900°C for 90 min for the last time, and coo...

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Abstract

The invention discloses an artificial articulation media layer and a preparation method thereof and relates to an artificial bone tissue material. A media layer with biotic compatibility, biotic degradation and cell inducing activity is formed on the surface of the artificial bone articulation of titanium alloy by compositing hydrogel and conductive polymer. The media layer can be taken as a buffer layer of the surface of the artificial articulation to reduce the loss of artificial articulation surface by friction and also as a framework material for the growth of bone cells and can induce the growth of the bone and facilitate the quick acceptance of the planted artificial articulation by the tissues. The artificial articulation media layer is a laminated structure, including a titanium alloy base layer, a nano hydroxyapatite layer, a biodegradable polyethylene glycol-lactic acid block copolymer layer and a polypyrrole layer with nano structure. An HA coating is constructed on the surface of the titanium alloy and then a hydrogel layer is constructed on the HA coating by adopting optical cross linking or free radical cross linking and finally pyrrole is in situ polymerized on the hydrogel layer, then the titanium alloy decorated with the ploypyrrole / glycol-lactic acid block copolymer / HA media layer is obtained.

Description

technical field [0001] The invention relates to an artificial bone tissue material, in particular to the construction of an artificial bone joint medium layer based on a hydrogel-conductive polymer nanocomposite material. Background technique [0002] Composite artificial joint prosthesis is the frontier topic of bone joint repair and replacement. Artificial joints first require affinity, and second, they must have good mechanical properties to ensure long-term use. The current artificial joints have made great progress in terms of materials, structural shapes, and optimized designs. From the point of view of the joint structure, the direct friction of the joint head on the articular surface will aggravate the bone loss, which requires the prosthesis material to have: ① self-supporting ability, ② surface biocompatibility, and ③ surface self-lubricating properties. Metal / polymer composite system to construct artificial prosthesis is a successful example. Metal materials ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/12A61L27/06A61L27/18C08G63/91C08G63/66C08J3/28A61F2/30
CPCA61F2/30767
Inventor 许一婷瞿波邓远名刘艳玲戴李宗
Owner XIAMEN UNIV
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